https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster2_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:38:092019-11-12 17:46:23Behavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line.
Androgens are known to strongly regulate the sebaceous gland. Relationships with testosterone have been reported and little is known about the role of DHEA. We showed that the most potent intracellular androgen metabolite, dihydrotestosterone (DHT), induced AR translocation, specific transcripts such as ras-related dexamethasone induced 1 (RASD1) and lipogenesis/lipid storage. We used these parameters to assess the behaviour and activity of the two main circulating androgens TESTO and DHEA, in comparison with DHT, in this model.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster1_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:542019-11-12 17:58:17Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster3_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:122019-11-12 17:36:48Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
We analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Androgens are key regulators of sebaceous function... A link between mTOR and androgen signaling has previously been reported...as well as a link between these processes and lipid synthesis...Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.
https://qima-lifesciences.com/wp-content/uploads/2017/05/mw_Adapalene-and-benzoyl-peroxide.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-05-01 13:15:422021-08-30 13:27:21A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
Acne in adult women is an increasing reason for dermatological consultations.
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662  constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2012-01-24 10:17:152019-11-13 11:28:55Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-11-20 14:50:532019-05-31 09:36:35Keratinocytes as targets for cytokines in skin inflammation
Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Expression-of-type-5alpha-reductase.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2000-12-10 13:36:372018-10-24 22:15:34Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis
We analysed the potential of a human epidermal tissue reconstituted by cell culture (RHE, provided by SkinEthic Laboratories, Nice, France) as a model for assessing 5-alphaR activity.