Scientific Publications

Pioneering discoveries that shape the future.

Publications

YearTitleAuthorJournalLinkKeywords
2025Human scalp hair follicles can "taste": Chemosensory signalling via the bitter taste receptor, TAS2R4, inhibits hair growth ex vivoJennifer Gherardini, Thomas Rouillé, Rivka C Stone, Markus Fehrholz, Wolfgang Funk, Jose Rodríguez-Feliz, Alan J Bauman, Tamás Bíró, Jérémy Chéret, Ralf PausBr. J Dermatol.Read the full storyHair growth, chemosensory receptor
2025Pemphigoid disease model systems for clinical translationMarvin Tigges, Sören Dräger, Ilaria Piccini, Katja Bieber, Artem Vorobyev, Janin Edelkamp, Marta Bertolini, Ralf J LudwigFront. Immunol.Read the full storyPemphigus, Pemphigoid diseases, model systems
2025Electrochemistry to monitor skin barrier: a proof-of-concept study on skin differentiation compared to corneometry, TEWL measurement, and High-Performance Liquid ChromatographyWilliam Richard, Alain Moga, Gilles Genain, Nicolas Amalric, Mélissa Eveillard, Jason Shourick, Sophie Le Tanneur, Elisa Funck-Brentano, Charbel Skayem, Stanislas Vandier, Tu Anh DuongJournal of Investigative DermatologyRead the full storySkin barrier, Electrochemistry, Sensors, Oxidative stress, Atopic Dermatitis
2025The melanocyte and nerve fiber cross-talk, facilitated also by semaphorin-4A, enhances UV-B-induced melanogenesisOnur Egriboz, Markus Fehrholz, Moe Tsutsumi, Marta Sousa, Jeremy Cheret, Wolfgang Funk, Maximilian Kückelhaus, Ralf Paus, Kentaro Kajiya, Ilaria Piccini, Marta BertoliniPigment Cell & Melanoma ResearchRead the full storySkin pigmentation, Melanocyte, Cutaneous Nerve Fibers, Re-innervated Skin, Secretome, Melanocyte-Neuron Cross-Talk, Semaphorin
2024A Dermocosmetic Balm Containing Vitamin B5, Madecassoside, and a Prebiotic Complex Significantly Improves Post Fractionated CO2 Laser Downtime Versus a Repairing Skin Care: Results of a Randomized Double Blind Intra-Individual Exploratory StudyJean-Michel Amici, Guénaelle Le Dantec, Ann' Laure Demessant, Catherine Queille-Roussel, Magali Procacci Babled, Anne Claire Cathelineau, Alix Danoy, Solene Trevisan, Merete HaedersdalJ Cosmet Dermatol.Read the full storydermocosmetic, post‐procedure, re‐epithelization, superficial CO2 laser, vitamin B5
2024SCAWA scales: a new digital tool for wrinkles clinical grading based on AIJuliette Rengot, Elodie Prestat-Marquis, Ingrid Aime, Jean-Robert Campos, Etienne Camel, Ghislain FrançoisInternational Journal of Cosmetic ScienceRead moreclaim substantiation; computer modelling; generative adversarial network; skin physiology/structure; standardization; wrinkle grading
2024Phototoxicity of the ethanolic extract of Skeletonema marinoi for the dermocosmetic improvement of acneJean-Baptiste Bérard, Tan-Sothea Ouk, Vincent Sol, Louise Lefoulon, Cornelia Landolt, Karine Grenier, Naima Saad, Elise Robert, Manoëlla Sibat, Nathalie Schreiber, Samuel Guenin, Laurent PicotMarine DrugsRead the full storyAcne, biofilm, Cutibacterium, dermocosmetics, infection, microalgae, pheophorbide a, photodynamic therapy, pigment, Skeletonema, Staphylococcus
2024Image Analysis of Xerosis and Atopic Dermatitis Following Prebiotic Skincare Regimen in Ethnically Diverse PatientsHawasatu Dumbuya, Zoe Diana Draelos, Eva Cassar, Charlotte Peucat, Caroline Le Floc’hc, Katharine PodimatisJournal of Drugs in Dermatology (JDD)Read the full storyAtopic Dermatitis, Skin of Color, Skin texture image analysis, SkinCam
2024Characterization of Skin Interfollicular Stem Cells and Early Transit Amplifying Cells during the Transition from Infants to Young ChildrenMarika Quadri, Caroline Baudouin, Roberta Lotti, Elisabetta Palazzo, Letizia Campanini, François-Xavier Bernard, Gaëlle Bellemere, Carlo Pincelli, Alessandra MarconiInternational Journal of Molecular SciencesRead the full storySkin barrier, keratinocyte stem cells (KSC), early transit amplifying (ETA) cells, neonatal skin, pediatric skin
2024In Vitro Study of Interleukin-6 when Used at Low Dose and Ultra-Low Dose in Micro-ImmunotherapyCamille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Mathieu Riffault, Ilaria FlorisLife (Basel)Read the full storyMicro-immunotherapy, low doses, ultra-low doses, interleukin-6, immune cells models, immune responses modulation, allergy
2024From consistent subjective assessment of skin sensitivity severity to its accurate objective scoringJuliette Rengot, Imke Meyer, Nathalie Chevrot, Marielle Le Maire, Marie Cherel, Elodie Prestat-Marquis, Dominik StuhlmannSkin Research and TechnologyRead the full storyArtificial intelligence; hyperspectral imaging; index; instrumental evaluation; multi-layer perceptron; questionnaire; sensitive skin.
2024Melatonin facts: Melatonin lacks immuno-inflammation boosting capacities at the molecular and cellular levelsJean A. Boutin, Valérie Hamon de Almeida, Nathalie Coussay, Celine Legros, Gilles Ferry, Karine ReybierBiochimieRead the full storyMelatonin, Immune-inflammation, Assays, PBMC, PMN, Interleukins
2024Revealing novel insights on how oral supplementation with collagen peptides may prevent hair loss: Lessons from the human hair follicle organ cultureKarin I Pappelbaum, Nicolina Virgilio, Lisa Epping, Bastiaan van der Steen, Francisco Jimenez, Wolfgang Funk, Janne Prawitt, Marta BertoliniJournal of functional foodRead the full storyCollagen Peptides, Dietary Supplementation, Hair Growth, Hair Shedding, Hair Loss, Hair Follicle Stem Cells
2024Understanding the Mode of Action of a Micro-Immunotherapy Formulation: Pre-Clinical Evidence from the Study of 2LEBV® Active IngredientCamille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Ilaria FlorisLife (Basel)Read the full storyEBV-associated diseases; Epstein–Barr virus; cytokines; immunotherapy; interleukin-2; micro-immunotherapy
2024A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic DermatitisJulia Tietz, Tea Gunde, Stefan Warmuth, Christopher Weinert, Matthias Brock, Alexandre Simonin, Chistian Hess, Maria Johansson, Fabio Spiga, Simone Muntwiler, Belinda Wickihalder, Dana Mahler, Dania Diem, Julia Zeberer, Robin Heiz, Naomi Flückiger, Noriko Shiraishi, Yoshihide Miyake, Nobuaki Takahashi, Markus Fehrholz, Marta Bertolini, Peter Lichtlen, David Urech, Daniel SnelJID InnovationsRead the full storyAtopic Dermatits, Cytokines, Inflammatory skin diseases, Pruritus
2023IL-34 Exerts Anti-Inflammatory Activities on Keratinocytes and Is Downregulated in Psoriatic-Inflamed SkinCroquette M, Faugeroux A, Fonlupt C, Godet J, Frouin É, Garcia M, Bernard FX, Cordier-Dirikoc S, Pedretti N, Larid G, Favot L, Roblot P, Boutin D, Hainaut-Wierzbicka E, Heymann D, Lecron JC, Morel F, Jégou JF.J Invest Dermatol.Read the full storyKeratinocyte, skin, inflammation, psoriasis, atopic dermatitis
2023Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplantsKeren A., Reich K., Bertolini M., Moga A., Riethmüller C., Ullmann Y., Paus R., Gilhar A.Allergy.Read the full storyIL-2; IL-4; LPS; SCID mice; perceived stress.
2023Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrierLemaire G., Olivero M., Rouquet V., Moga A., Pagnon A., Cenizo V., Portes P.PLoS OneRead the full storyceramides, essential oils, skin barrier, skin, skin explant, 3D model
2023Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in DandruffJourdain R., Moga A., Magiatis P., Fontanié M., Velegreki A., Papadimou C., Rahoul V., Guéniche A., Chopra T., Gaitanis G.Acta Dermato-VenereologicaRead the full storyDandruff, Malassezia restricta, scalp, skin barrier, lipoperoxidation, sebuum
2023Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant ExtractsKondratjeva J., Brun J., Amalric N., Moog F., Combarros D., Pressanti C., Zemirline C., Maubert N., Ollivier E., Gatellet M., Cadiergues Mc.Vet. Sci.Read the full storyOphytrium; Seboliance; canine; mousse; seborrhea; shampoo; skin.
2023Spatial distribution and functional impact of human scalp hair follicle microbiotaMarta B. Lousada, Janin Edelkamp, Tim Lachnit, Markus Fehrholz, Irena Pastar, Francisco Jimenez, Hanieh Erdmann, Thomas C. G. Bosch, Ralf PausJIDRead the full storyHair follicle microbiome, LCM
2023Biological effects of electrical epilation on human hair follicles and perifollicular skin ex vivoMarta Bertolini, Jennifer Gherardini, Jéremy Chéret, Majid Alam, Mathias Sulk, Natalia V Botchkareva, Tamás Bíro, Wolfgang Funk, Frieder Grieshaber, Ralf PausInt J Cosmet SciRead the full storyEpilation, Skin organ culture, Hair Removal
2023“Speed-aging” of human skin in serum-free organ culture ex vivo: An instructive novel assay for preclinical human skin aging research demonstrates senolytic effects of caffeine and 2,5-dimethylpyrazinevan Lessen M, Mardaryev A, Broadley D, Bertolini M, Edelkamp J, Kückelhaus M, Funk W, Bíró T, Paus RExp DermatolRead the full storySkin Aging and Senescence, Skin organ culture, Spontaneous aging in serum-free medium
2023Management of the human hair follicle microbiome by a synthetic odorantEdelkamp J, Bispo Lousada M, Pinto D, Chéret J, Calabrese FM, Jiménez F, Erdmann H, Wessel J, Phillip B, De Angelis M, Rinaldi F, Bertolini M, Paus RJDSRead the full storyMicrobiome, Cosmetics, Hair follicle disorders, Antimicrobial peptides
2023Preliminary evidence that Merkel cells exert chemosensory functions in human epidermisPiccini I, Chéret J, Tsutsumi M, Sakaguchi S; Ponce L, Almeida, L, Funk W, Kückelhaus M; Kajiya K, Paus R, Bertolini MExp DermatolRead the full storyMerkel cell, Chemosensation, Olfactory receptor, Vesicle release
2023mTORC1 activity negatively regulates human hair follicle growth and pigmentationSuzuki T, Chéret J, Dinelli Scala F, Akhundlu A, Gherardini J, Demetrius D, O'Sullivan JDB, Kuka Epstein G, Bauman AJ, Demetriades C, Paus REMBO ReportsRead the full storyCanities, Hair follicle pigmentation, Hair follicle organ culture, Melanogenesis, mTORC1 signaling
2023Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic diseaseCole S, Manghera A, Burns L, Barrett J, Yager N, Rhys H, Skelton A, Cole J, Goodyear CS, Griffiths M, Baeten M, Bertolini M, Shaw S, Al-Mossawi H, Maroof AJournal of Allergy and Clinical ImmunologyRead the full storyPsoriasis, IL-17 signaling, STAT signaling, lesional skin organ culture, scRNAseq
2023Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profileLousada MB, Edelkamp J, Lachnit T, Fehrholz M, Jimenez F, Paus RBMC Research NotesRead the full storyHair follicle organ culture, Microbiome, Laser-Capture Microdissection
2023Involvement of ILC1-like innate lymphocytes in human autoimmunity: lessons from alopecia areataLaufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar AeLifeRead the full storyAlopecia Areata, Hair Loss, Hair growth, Humanized mouse model, innate lymphoid cells-type 1
2023Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivoEdelkamp J, Lousada MB, Pinto D, Chéret J, O'Sullivan JDB, Biundo A, Jimenez F, Funk W, Roessing C, Rippmann V, Paus R, Bertolini MSkin Pharmacol. Physiol.Read the full storySkin organ culture, Chemosensation, Olfactory Receptors, Microbiome, Antimicrobial peptides
2023Concentration-dependent stimulation of melanin production as well as melanocyte and keratinocyte proliferation by melatonin in human eyelid epidermisSevilla A, Chéret J, Lee W, Paus RExp. Dermatol.Read the full storyFull-thickness eyelid skin organ culture, melatonin, melanogenesis,
2023Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplantsKeren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar AAllergyRead the full storyAtopic Dermatitis; humanized mouse model; xenotransplants; skin barrier deficits
2023Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in DandruffRoland Jourdain, Alain Moga, Prokopios Magiatis, Maxime Fontanié, Aristea Velegraki, Chrysanthi Papadimou, Valérie Rahoul, Audrey Guéniche, Tarun Chopra, George GaitanisActa Derm Venereol.Read the full storyDandruff, Malassezia restricta, lipoperoxidation, hair, cosmetics
2023A Dermocosmetic Significantly Reduces the Frequency and Intensity of Facial Skin Intolerability and Sensitivity in Subjects with Skin Intolerant to Skin Care Products and Sensitive Skin.Kerob D, Czermanska A, Karamon EM, Moga A, Lecerf G, Nioré M, Le Dantec G, Le Floc'h C, Tan J.Clin Cosmet Investig Dermatol.Read the full storyallergic prone skin; dermocosmetic; sensitive skin.
2023Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplantsKeren A., Reich K., Bertolini M., Moga A., Riethmüller C., Ullmann Y., Paus R., Gilhar A.Allergy. 2023;00:1–16Read the full storyIL-2, IL-4, LPS, perceived stress, SCID mice
2023Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithmQuentin Marin Dit Bertoud, Clémence Bertold, Khaled Ezzedine, Amit G Pandya, Marie Cherel, Alejandro Castillo Martinez, Marie-Anne Seguy, Marwa Abdallah, Jung Min Bae, Markus Böhm, Davinder Parsad, David Rosmarin, Albert Wolkerstorfer, Philippe Bahadoran, Manon Blaise, Pierre-Michel Dugourd, Valérie Philippo, Jean-Michel Delaval, Thierry PasseronBr J Dermatol.Read the full storyvitiligo, artificial intelligence, clinical trial, instrumental evaluation, skin image, skin depigmentation
2023Predictors of female age, health and attractiveness perception from skin feature analysis of digital portraits in five ethnic groupsRainer Voegeli, Remo Campiche, Romain Biassi, Anthony V Rawlings, Todd K Shackelford, Bernhard FinkInt J Cosmet Sci.Read the full storycross-cultural ethnicity, face perception, skin image analysis, women
2023Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisersSarah Gougeon, Elsa Hernandez, Nathalie Chevrot, Thibault Vergne, Marie Cherel, Elodie Prestat-Marquis, Matthieu Jomier, Elodie Burty-ValinSkin Res TechnolRead the full story3D skin imaging, connected imaging, moisturiser, nomadic imaging, roughness, skin microrelief,skin pattern
2023Video-based paired comparison to evaluate some cosmetic products under camera movement for dynamic performanceEmilie Yokoyama, Ghislain Francois, Margalith Harrar, Chafik Bachatene, Kumiko Udodaira, Solène Trévisan, Alexandre Nicolas, Damien Velleman, Frederic FlamentInt J Cosmet Sci.Read the full storycosmetic evaluation, clinical evaluation, skin imaging, skin video, 3D skin imaging
2023Comparative analysis of original face and skin-warped average face images for the scoring of skin attributesQuentin Marin, Tatsuya Honda, Yuri Okano, Marie Cherel, Elodie Prestat-MarquisSkin Res TechnolRead the full storyageing signs, average face, claim substantiation, digital image, skin grading, statistics
2023Lip color measurement: A new hyperspectral imaging deviceHéloïse Vergnaud, Marie Cherel, Ghislain Francois, Zoé Charton, Eléonore Loescher, Laurence Caisey, Germaine GazanoSkin Res TechnolRead the full storyskin color, lips, lip color
2023Comparative analysis of original face and skin-warped average face images for the scoring of skin attributesMarin Q., Honda T., Okano Y., Cherel M., Prestat-Marquis E.Skin Res Technol. 2023;29(4)Read the full storyageing signs, average face, claim substantiation, digital image, skin grading, statistics
2023Exploring sensitive skin to design reliable measurementsJuliette Rengot, Dominik Stuhlmann, Imke Meyer, Nathalie Chevrot, Marielle Le Maire, Juliet Chamla, Jordan Gierschendorf, Marie Cherel, Elodie Prestat-MarquisSkin Res TechnolRead the full storysensitive skin, skin imaging, statistics, cosmetics, clinical evaluation, SpectraFace hhyperspectral images
2022IL-17 and IL-22 are pivotal cytokines to delay wound healing of S. aureus and P. aeruginosa infected skin.Lecron JC, Charreau S, Jégou JF, Salhi N, Petit-Paris I, Guignouard E, Burucoa C, Favot-Laforge L, Bodet C, Barra A, Huguier V, Mcheik J, Dumoutier L, Garnier J, Bernard FX, Ryffel B, Morel F. IFront Immunol.Read the full storyTh17; cytokine; inflammation; pathogen; skin; wound healing.
2022Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytesCordier-Dirikoc S., Pedretti N., Garnier J., Clarhaut-Charreau S., Ryffel B., Morel F., Bernard Fx., Hamon De Almeida V., Lecron Jc. And Jegou Jf.Front. Immunol.Read the full storyIL-1; epidermal lesion; fibroblasts; keratinocytes; skin; sterile inflammation.
2022Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis ExternaMoog F., Mivielle J., Brun J., Oana Dumitrache M., Amalric N., Lecru La., Pressanti C., Kondratjeva J., Combarros D., Fantini O., Cadiergues Mc.Vet. Sci.Read the full storycytokines; dog; ear cleanser; ear infection; ear lipids; erythemato-ceruminous otitis.
2022Clinical Evaluation of Indian Sandalwood Oil and Its Protective Effect on the Skin against the Detrimental Effect of ExposomeLutchmanen Kolanthan V., Brown A., Soobramaney V., Philibert Eg., Newton V., Hosenally M., Nusayha Sokeechand B., Petkar G., Moga A., Andres P., Bibi Mandary M., Hettiarachchi D.CosmeticsRead the full storyoxidative stress; blue light; pollution; in vivo; Indian sandalwood oil; squalene
2022Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange-Preliminary ResultsLecru La., Combarros D., Moog F., Marinovic L., Kondratjeva J., Amalric N., Pressanti C., Cardiergues Mc.AnimalsRead the full storyOtodectes cynotis; atopic dermatitis; biomarkers; dog; inflammation; interleukin-8; otitis.
2022The Unitary Micro-Immunotherapy Medicine Interferon-γ (4 CH) Displays Similar Immunostimulatory and Immunomodulatory Effects than Those of Biologically Active Human Interferon-γ on Various Cell Types.Jacques C, Chatelais M, Fekir K, Brulefert A, Floris I.Int J Mol Sci.Read the full storycentesimal Hahnemannian dilution; cytokines secretion; homeopathically prepared interferon-γ; immune-related markers; immunomodulation; immunostimulant; in vitro; interferon-γ; micro-immunotherapy; unitary medicine.
2022Antiviral Effect of hBD-3 and LL-37 during Human Primary Keratinocyte Infection with West Nile Virus.Chessa C, Bodet C, Jousselin C, Larivière A, Damour A, Garnier J, Lévêque N, Garcia M.Viruses.Read the full storyLL-37; West Nile virus; antimicrobial peptides; antiviral; flavivirus; hBD-3; immunomodulation; keratinocytes.
2022Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex VivoHoresh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus RJIDRead the full storyHF organ culture ex vivo; HPS-Axis; brain-HF-axis; neuroendocrinology
2022Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy?Gherardini J, Rivas KE, Chéret J, Strbo N, Paus RJEADVRead the full storyOuter Root Sheath Keratinocytes; in vitro models, Alopecia Areata; IP collapse
2022Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte ProliferationWikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus RJIDRead the full storySebaceous gland function, MPZL3
2022The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzleO'Sullivan JDB , Peters EMJ, Amer Y, Atuluru P, Chéret J, Rosenberg AM, Picard M, Paus RFront Neuroendocrinol.Read the full storybrain-HF axis; perceived stress in hair greying and hair loss, neuroendocrinology
2022Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactionsPlatt CI, Cheret J, Paus RArch Dermatol Res.Read the full storyOrganotypic model, 3D dermal papilla spheroids, Epithelial mesenchymal interaction, hair matrix
2022A plaidoyer for the use of human skin xenotransplant mouse models in preclinical psoriasis researchGilhar A, Reich K, Keren A, Paus RJ Eur Acad Dermatol Venereol.Read the full storyPsoriasis, humanized mouse model, xenotransplantation
2022Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic PhenotypePiccini I, Sousa M, Altendorf S, Jimenez F, Rossi A, Funk W, Biró T, Paus R, Seibel J, Jakobs M, Yesilkaya T, Edelkamp J, Bertolini MNutrients.Read the full storyFemale pattern hair loss, hair follicle, metabolism, nutrient supplementation
2022Circadian rhythms in psoriasis and the potential of chronotherapy in psoriasis managementLuengas-Martinez A, Paus R, Iqbal M, Bailey L, Ray DW, Young HSExp. DermatolRead the full storyVEGF-A, chronotherapy, circadian rhythms, psoriasis.
2022Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational HorizonsSenna MM, Peterson E, Jozic I, Chéret J, Paus RJID Innov.Read the full story5α-reductase inhibitor, alopecia areata, androgenetic alopecia, corticotropin-releasing hormone, epithelial‒mesenchymal transition, frontal fibrosing alopecia, hair follicle, immune privilege, keratin, keratinocyte, lichen planopilaris, macrophage, major histocompatibility complex, primary cicatricial alopecia, personal care product, peroxisome proliferator–activated receptor-γ, stem cell, substance P, epithelial hair follicle stem cell, α-melanocyte-stimulating hormone
2022Hydra and the hair follicle - An unconventional comparative biology approach to exploring the human holobiontLousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCGBioessays.Read the full storyAntimicrobial peptides, microbial ecology, microbiome, model organisms
2022Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin agingWikramanayake TC, Chéret J, Sevilla A, Birch-Machin M, Paus RExpert opinion on Therapeutic TargetsRead the full storyReactive oxygen species (ROS), alopecia, appendage, epidermis, hair follicle, mitochondria, myelin protein zero-like 3 (MPZL3), sebaceous gland, skin cancer
2022Revisiting the role of melatonin in human melanocyte physiology: A skin context perspectiveSevilla A, Chéret J, Slominski RM, Slominski AT, Paus RJ. Pineal resRead the full storyHair follicle, human skin, melanocyte, melatonin, pigmentation
2022An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivoCampiche R, Le Riche A, Edelkamp J, Fernandez Botello A, Martin E, Gempeler M, Bertolini MInt J Cosmet Sci.Read the full storyLeontopodium alpinum, anagen phase, anti-hair loss, hair follicle, hair growth, versican
2022Human organ reju-venation by VEGF-A: Lessons from the skinKeren A, Bertolini M, Yaniv K, Ullmann Y, Paus R, Gilhar ASci. AdvancesRead the full storyVEGF-A, skin aging, skin rejuvenation, humanized mouse model, skin organ culture ex vivo
2022Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre-clinical in vivo assay for androgenetic alopecia researchGilhar A, Keren A, Ullmann Y, Wu J, Paus RExp Dermatol.Read the full storyMouse model, xenotransplant, preclinical model, hair growth, hair loss, androgenetic alopecia
2022Growth Hormone and the Human Hair FollicleHoresh E.J, Chéret J, Paus RInt J Mol Sci.Read the full storyGrowth hormone, neuroendocrine, hair follicle, hair growth
2022Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells.Monjotin N, Tenca G.Microvasc Res.Read the full storyCalcium mobilization; Chronic venous disease; Cyclo 3® Fort; Edema; Lymphatic contractility; Lymphatic muscle cell; Lymphotonic; MPFF; Ruscus/HMC/Vit C.
2022Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract.Segarra S, Naiken T, Garnier J, Hamon V, Coussay N, Bernard FX.Vet Sci.Read the full storyantimicrobial peptides; canine atopic dermatitis; filaggrin; glycosaminoglycans; hyaluronic acid; sphingolipids; sphingomyelin; β-defensin.
2022Transient and reversible reduction of stratum corneum filaggrin degradation products after allergen challenge in experimentally mite-sensitised atopic dogsThierry Olivry, Judy S Paps, Nicolas AmalricVet Dermatol.Read the full storyAllergens, Animals, Dermatitis, Atopic / veterinary, Dog Diseases, Dogs, Epidermis, Filaggrin Proteins, Mites, Skin
2022A comprehensive comparison of facial skin hydration based on capacitance and conductance measurements in Chinese womenRainer Voegeli, Marie Cherel, Rotraut Schoop, Anthony V RawlingsInt J Cosmet Sci.Read the full storycolour mapping, facial skin hydration, moisturization, skin capacitance, skin conductance,stratum corneum
20225-α reductase inhibition by Epilobioum fleischeri extract modulates facial microbiota structureRiccardo Sfriso, Joshua Claypool, Magalie Roche, Dominik ImfeldInt J Cosmet Sci.Read the full storyclaim substantiation, Epilobium fleischeri, microbiota, reference frames, skin care, skinmicrobiome
2022Identifying patterns behind the changes in skin pores using 3-dimensional measurements and K-means clusteringSeongwoo Lee, Marie Cherel, Sarah Gougeon , Euitaek Jeong, Jun-Man Lim, Sun Gyoo ParkSkin Res TechnolRead the full story3D assessment of pores, aging, connecting phenomena of skin pores, K-means clustering, skinpores, skin surface, wrinkles
2022Analysis of correlation and construction of a predictive model of skin transparency using parameters from digital images of the faceQuentin Marin, Tatsuya Honda, Hiroaki Nakajima, Yuri Okano, Marie Cherel, Elodie Prestat-MarquisSkin Res TechnolRead the full storyColorface®, predictive model, skin transparency, visual clues
2022Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisersGougeon S., Hernandez E., Chevrot N., Vergne T., Cherel M., Prestat-Marquis E., Jomier M., Burty-Valin E.Skin Res Technol. 2023;29(1)Read the full story3D skin imaging, connected imaging, moisturiser, nomadic imaging, roughness, skin microrelief, skin pattern, cosmetics
2021The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendagesYue ZC, Lei MX, Paus R, Chuong CMBiol Rev Camb Philos Soc.Read the full storyVGEF, psoriasis, therapeutic strategies
2021Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivoNicu C, Jackson J, Shahmalak A, Pople J, Ansell D, Paus RArch Dermatol Res.Read the full storyhair follicle, adiponectin, pigmentation, hair follicle organ culture, ex vivo, dermal papilla, WNT
2021Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldnessHochfeld L.M, Bertolini M, Broadley D, Botchkareva N.V, Betz R.C, Schoch S, Nöthen M.M, Heilmann-Heimbach S.PLoS One.Read the full storyhair follicle, male pattern hair loss, WNT, genetic
2021Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylaseFiglak k, Williams G, Bertolini M, Paus R, Philpott M.P.Sci Rep.Read the full storyhair follicle, metabolism, outer root sheath keratinocytes, hair follicle organ culture, ex vivo
2021Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicleUchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R.J Autoimmun.Read the full storyalopecia areata, autoimmunity, resident human γδT-cells, hair follicle, MICA, NKG2D, stress, ex vivo model
2021The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targetsSuzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R.Exp Dermatol.Read the full storyhair growth, skin, psoriasis, hair follicle
2021PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transitionPiccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, Purba TS, Hardman J, Erdmann H, Jimenez F, Paus R, Bertolini M.Br J Dermatol.Read the full storyalopecia, chemotherapy, treatment, prevention, PPARγ agonist
2021Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology.Wikramanayake TC, Nicu C, Chéret J, Czyzyk TA, Paus R.Bioessays.Read the full storyMyelin Protein Zero-like 3, CLOCK, PPARγ, mitochondria
2021A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?Limbu SL, Purba TS, Harries M, Wikramanayake TC, Miteva M, Bhogal RK, O'Neill CA, Paus R.Bioessays.Read the full storydandruff, scalp, hair follicle, cosmeceuticals
2021Quantitative mapping of human hair greying and reversal in relation to life stressRosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M.Elife.Read the full storystress, premature greying, hair shaft proteomics
2021A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?Ivan Jozic, Jérémy Chéret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf PausBiomedicinesRead the full storycaveolin-1, scarring alopecia, hair follicle stem cells, immune privilege collapse
2021Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivoChéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R.J Invest Dermatol.Read the full storyskin explants, re-innervation, iPS cells
2021Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotypeThibault Kervarrec, Jérémy Chéret, Ralf Paus, Roland Houben, David SchramaExp Dermatol.Read the full storyMerkel cells, carcinoma, polyomavirus, hair follicle, malignant transformation, tumor
2021Can antibiotic-induced changes in the composition of the hair follicle microbiome regulate human hair growth?Bispo Lousada M, Edelkamp J, Lachnit T, Erdmann H, Paus RExp Dermatol.Read the full storymicrobiome, hair growth, hair follicle
2021UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentationTiede S, Hundt JE, Paus RJ Invest Dermatol.Read the full storyhair follicle, pigmentation, therapeutics, greying
2021Quantitative mapping of human hair greying and reversal in relation to life stressRosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard MElife.Read the full storyhair follicle, greying, pigmentation, stress
2021Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivoChéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus RJ Invest Dermatol.Read the full storymodel, skin re-innervation, itch irritation
2021A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus RBiomedicines.Read the full storyhair follicle, alopecia target, frontal fibrosing alopecia
2021Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patientsDi Landro A, Naldi L, Glaser E, Paus R, Tosti AExp Dermatol.Read the full storyContinuous Positive Airway Pressure, paracetamol, systemic steroids, anticoagulants, clinical manifestations
2021Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal MucosaYamanaka-Takaichi M, Mizukami Y, Sugawara K, Sunami K, Teranishi Y, Kira Y, Paus R, Tsuruta DInt J Mol Sci.Read the full storyinflammation, stem cell factor, antalarmin, therapeutics
2021Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenanceMardaryev A, van Lessen M, Alam M, Acosta FJ, Bíró T, Paus RJ Invest Dermatol.Read the full storyhair cycle, hair follicle, triphenylphosphine oxide, TRPM5
2021Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel TherapeuticsHawkshaw NJ, Paus RTrends Pharmacol Sci.Read the full storyhypertrichosis, human model systems, immunosuppressive therapy
2021The biology of human hair greyingO'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus RBiol Rev Camb Philos Soc.Read the full storymelanogenesis, bulge melanocyte stem cells, pigmentation, HFPU melanocyte survival
2021Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced AlopeciaHaslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue ZJ Invest Dermatol.Read the full storyantimitotic, apoptosis-promoting, MAPK-Shh axis
2021Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status?Purba TS, Berriche L, Paus RExp Dermatol.Read the full storyWarburg effect, hair growth, immunological HF microenvironment
2021Human epithelial stem cell survival within their niche requires "tonic" cannabinoid receptor 1-signaling - Lessons from the hair follicleSugawara K, Zákány N, Tiede S, Purba T, Harries M, Tsuruta D, Bíró T, Paus RExp Dermatol.Read the full storyendocannabinoid system, organ-cultured human HFs, human adult epithelial stem cell
2021Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging ResearchStone RC, Aviv A, Paus RJ Invest Dermatol.Read the full storypigmentary unit, chemotherapy-induced alopecia, telogen effluvium, androgenetic alopecia, cicatricial alopecia
2021Dermal adipose tissue secretes HGF to promote human hair growth and pigmentationNicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N, Farjo B, Pople J, Bhogal R, Hardman JA, Plikus MV, Ansell DM, Paus RJ Invest Dermatol.Read the full storyhepatocyte growth factor, human HF-dWAT co-culture, human hair growth, pigmentation
2021Shining a (blue) light on hair follicle chronobiology and photobiomodulationPaus RExp Dermatol.Read the full storyhair follicles, metabolism, clock gene
2021Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactionsPlatt CI, Chéret J, Paus RArch Dermatol Res.Read the full storymicrodissected scalp hair follicles, dermal papilla, 3-dimensional (3D) spheroids
2021Translational Neuroendocrinology of Human Skin: Concepts and PerspectivesRamot Y, Böhm M, Paus RTrends Mol Med.Read the full storyneurohormones, neuropeptides, neurotransmitters, human skin physiology
2021Barrier disruption, dehydration and inflammation: Investigation of the vicious circle underlying dry skinCécile Bize, Erwan Le Gélébart, Alain Moga, Bruno Payré, Christine GarciaInt J Cosmet Sci.Read the full storyHelichrysum stoechas extract; dry skin; inflammation; inflamm’dryness; skin barrier.
2021A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smokeDalrymple A., Mcewan M., Brandt M., Bielfeldt S., Bean Ej., Moga A., Coburn S., Hardie G.Skin Res Technol.Read the full storycigarette smoke; cosmetic; electronic cigarette/e-cigarette; hygiene; skin damage; skin staining; tobacco heating product.
2021Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot StudyPressanti C., Ravailhe E., Castellote-Brun J., Amalric N., Lecru La., Kondratjeva J., Moog F., Daniel Combarros D., Douet Jy, Cadiergues Mc.Veterinary DermatologyRead the full storyConjunctivitis, diagnosis, Conjunctivitis, Allergic, veterinary medecine, Cytokines, Dog Diseases / diagnosis, Dogs, Tears
2021Anti-pollution effects of two antioxidants and a chelator—Ex vivo electron spin resonance and in vivo cigarette smoke model assessments in human skinBielfeldt S., Jung K., Laing S., Moga A., Wilhelm Kp.Skin Res Technol.Read the full storyESR; Urban Dust; anti-pollution; antioxidants; chelators; cigarette smoke model; in vivo model; malondialdehyde; particulate matter; squalene oxidation, human skin
2021Cross-cultural perception of female facial appearance: A multi-ethnic and multi-centre studyRainer Voegeli, Rotraut Schoop, Elodie Prestat-Marquis, Anthony V Rawlings, Todd K Shackelford, Bernhard FinkPloS OneRead the full storyFace, Ethnicities , African people, French people, Cross-cultural studies, Chinese people, Health informatics , Research assessment, skin imaging, skin imaging
2021Real-time skin chromophore estimation from hyperspectral images using a neural networkLou Gevaux, Jordan Gierschendorf, Juliette Rengot, Marie Cherel, Pierre Séroul, Alex Nkengne, Julie Robic, Alain Trémeau, Mathieu HébertSkin Res TechnolRead the full story3D skin imaging, cosmetics, artificial intelligence, neural network, hyperspectral images, clinical evaluation, non invasive
2021Differences between perceived age and chronological age in women: A multi-ethnic and multi-centre studyRainer Voegeli, Rotraut Schoop, Elodie Prestat-Marquis, Anthony V Rawling,, Todd K Shackelford, Bernhard FinkInt J Cosmet Sci.Read the full storychronological age, cross-cultural, ethnicity, face, perceived age, perception, women
2020Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse ModelGilhar A, Laufer Britva R, Keren A, Paus RJ Investig DermatolRead the full storyalopecia areata, therapeutic effects, preclinical
2020The Evolving Pathogenesis of Alopecia Areata: Major Open QuestionsPaus RJ Investig Dermatol.Read the full storyautoimmune alopecia areata, atopic dermatitis, hair follicle
2020Mouse models of atopic dermatitis: a critical reappraisalGilhar A, Reich K, Keren A, Kabashima K, Steinhoff M, Paus RExp Dermatol.Read the full storyatopic dermatitis, human skin xenotransplants, SCID mice
2020Towards a renaissance of dermatoendocrinology: Selected current frontiersBöhm M, Paus RExp Dermatol.Read the full story
2020Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibers and native human dermal mast cells ex vivoChéret J, Ponce L, Le Gall-Ianotto C, Bertolini M, Paus RExp. Dermatol.Read the full storyhuman skin organ culture, functional sensory skin nerves, neurogenic skin inflammation
2020Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cyclingNicu C, Wikramanayake TC, Paus RExp. Dermatol.Read the full storyintrinsic oscillator system, myelin protein zero- like 3, telogen‐to‐anagen transition
2020Pro-inflammatory Vδ1 + T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair folliclesUchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus RJ Dermatol Sci.Read the full storyskin-resident γδT-cells, alopecia areata, hair follicle, innate immunity
2020The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature SynthesisHaslam IS, Paus RBioessaysRead the full storyhuman hair growth, regeneration, hair loss therapy, stem cell niches
2020A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivoBertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus RBr J Dermatol.Read the full storyWnt signalling, hair growth, hypertrichosis, catagen development
2020Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis?Hardman JA, Nicu C, Tai C, Harries M, Mironov A, Purba TS, Paus RJ Dermatol. Sci.Read the full storyautophagy, lysosomal degradation, ATG5, catagen,
2020Exploring the human hair follicle microbiomeLousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus RBr. J Dermatol.Read the full storymicrobiota, human holobiont, antimicrobial peptides, microbial survival
2020Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopeciaHaslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue ZJ Invest Dermatol.Read the full storyclinical oncology, hair matrix keratinocytes, Shh signaling, hair follicle damage
2020Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?Paus R, Ramot Y, Kirsner RS, Tomic-Canic MExp. Dermatol.Read the full storytopical hormone therapy, thyroid hormone receptor, L‐thyroxine (T4), skin ulcers, telogen effluvium
2020Hair follicle immune privilege and its collapse in alopecia areataBertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus RExp. Dermatol.Read the full storyMHC class, mast cells, CD4+, CD8+, NK cell, disease relapse
2020Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore ® , Improves Telogen Effluvium-Associated ParametersJimenez F, López E, Bertolini M, Alam M, Chéret J, Westgate G, Rinaldi F, Marzani B, Paus R.J Cosmet Dermatol.Read the full storyOR2AT4 olfactory receptor, Sandalore®, claim substantiation, hair growth, hair treatment, telogen effluvium
2020Vascular Endothelial Growth factor-A as a Promising Therapeutic Target for the Management of PsoriasisLuengas-Martinez A, Hardman-Smart J, Paus R, Young HS.Exp. Dermatol.Read the full storyangiogenic mediator, bevacizumab, personalised medicine, vascular endothelial growth factor A
2020Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivoPost H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R.Arch Dermatol. ResRead the full storyhypoxia, skin organ culture, Wound healing, preclinical
2020Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture modelLuengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HSSkin Pharmacol PhysiolRead the full storyanti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis
2020Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivoChéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus RJ DermatolRead the full storyneurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses
2020Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermisOláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus RExp DermatolRead the full storykeratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage
2020Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 SkewingDel Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E.Br J DermatolRead the full storylesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments
2020Hair(y) matters in melanoma biologyBarbara Bedogni, Ralf PausTrends in Molecular MedicineRead the full storymetastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy
2020New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus RBr J DermatolRead the full storyhuman hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine
2020An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytesAlam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus RBr J DermatolRead the full storyhuman scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth
2020Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes.Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T.J Invest DermatolRead the full storyhair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth
2020Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis.Atanaska Dobreva, Ralf Paus, N. G. CoganBull Math BiolRead the full storyautoimmune disease, alopecia areata, partial differential equations, humanized mouse model
2020Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy?Cheret J, Gherardini J, Bertolini M, Paus R.Br J DermatolRead the full storyhair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone
2020Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs?Carré JL, Suzuki T, Paus RExp DermatolRead the full storytrichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis
2020Neuroendocrinology and neurobiology of sebaceous gland.Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus RBiol Rev Camb Philos SocRead the full storynervous system, pituitary control, sebaceous glands, homeostasis
2020Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro TJ Invest DermatolRead the full storyhair follicle, ex vivo organ culture, toll-like receptor, hair morphology
2020Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata.Laufer BR, Keren A, Paus R, Gilhar A.Br J DermatolRead the full storyhair loss, hair follicle, phosphodiesterase inhibitor, therapeutics
2020Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo.Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus RPLoS OneRead the full storymacrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus
2020Schwann cells as underestimated, major players in human skin physiology and pathology.Bray ER, Cheret J, Yosipovitch G, Paus R.Exp DermatolRead the full storyaxon regeneration, wound healing, atopic dermatitis, psoriasis
2020Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo.Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R.Int J Cosmet SciRead the full storyfull thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties
2020Pigmentation effects of blue light irradiation on skin and how to protect against themCampiche R, Curpen SJ, Lutchmanen-Kolanthan V, Gougeon S, Cherel M, Laurent G, Gempeler M, Schuetz R.Int J Cosmet Sci.Read the full storypigmentation, blue light, skin protection
2020Topical niacinamide enhances hydrophobicity and resilience of corneocyte envelopes on different facial locationsR Voegeli, D Guneri, M Cherel, B Summers, M E Lane, A V RawlingsInt J Cosmet Sci.Read the full storyskin barrier, skin imaging, corneocytes, skin aging, hydrophobicity, clinical evaluation, stripping
2020An image-based mapping of significance and relevance of facial skin colour changes of females living in ThailandP Séroul, R Campiche, S Gougeon, M Cherel, A V Rawlings, R VoegeliInt J Cosmet Sci.Read the full storyclaim substantiation, facial mapping, relevance, significance, skin colour, statistics
2020Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo.Boukhedouni N, Martins C, Darrigade AS, Drullion C, Rambert J, Barrault C, Garnier J, Jacquemin C, Thiolat D, Lucchese F, Morel F, Ezzedine K, Taieb A, Bernard FX, Seneschal J, Boniface K.JCI InsightRead the full storyAutoimmune diseases; Cytokines; Dermatology; Inflammation; Skin.
2020An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica.Awada R, Verdier D, Froger S, Brulard E, de Faria Maraschin S, Etienne H, Breton D.Sci Rep.Read the full storyPlant, coffea, high throughput screening
2020Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigmBollinger Caroline., Duong Tu Anh., Genain G., Amalric N., Moga A., Richard W., Vandier S.Skin Res Technol.Read the full storyCosmetics, Prospective Studies, Skin Care, Technology, skin pigmentation, cigarette smoke, environmental stress
2020A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coatsCombarros D., Castilla-Castaño E., Lecru La., Pressanti C., Amalric N., Cadiergues Mc.Plefa (Prostaglandins, Leukotrienes And Essential Fatty Acids)Read the full storyCanine; Docosahexaenoic acid; Eicosapentaenoic acid; Haircoat; Omega-3 fatty acids; Skin, veterinary medecine.
2020A novel method for evaluating the effect of pollution on the human skin under controlled conditionsCurpen S., Francois-Newton V., Moga A., Hosenally M., Petkar G., Soobramaney V., Ruchaia B., Lutchmanen Kolanthan V., Roheemun N., Sokeechand Bn., Aumeeruddy Z., Ramracheya Rd.Skin Research & TechnologyRead the full storybiomarkers; controlled pollution exposure system; cosmetic claims; pollution; skin.
2019JAK inhibitors and alopecia areata.Gilhar A, Keren A, Paus R.LancetRead the full storysystemic therapy, cytokines, autoimmune disease
2019Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine.Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M.Int J Cosmet SciRead the full storyex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance
2019Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo.Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R.Arch Dermatol ResRead the full storyskin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration
2019Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?Nicu C, Hardman JA, Pople J, Paus R.Exp DermatolRead the full storyhair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle
2019Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia.Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME.JAMA DermatolRead the full storypersistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy
2019Hair growth control by innate immunocytes: Perifollicular macrophages revisited.Muneeb F, Hardman JA, Paus R.Exp DermatolRead the full storyhair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant
2019Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R.PLoS OneRead the full storyfull thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism
2019Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything?Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F.Dermatol SurgRead the full storyhair follicles, scar formation, hair growth, wound healing, human skin
2019Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo.Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J.Br J DermatolRead the full storylabel‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix
2019Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis.Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G.Exp DermatolRead the full storyhair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation
2019Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X.Br J DermatolRead the full storygenetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis
2019Hair disorders in patients with cancer.Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME.J Am Acad DermatolRead the full storychemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients
2019Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias.Harries M, Imanishi H, Paus R.J Am Acad DermatolRead the full storylaser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation
2019TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro.Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG.J Invest DermatolRead the full storycalcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves
2019Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo.Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R.J Invest DermatolRead the full storyhuman hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation
2019Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease.Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R.PloS OneRead the full storyflow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction
2019Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation.Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R.Br J DermatolRead the full storyin situ hybridization, human telogen, scalp hair follicle sections, hair biology
2019Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage.Smart E, Farjo N, Farjo B, Haslam IS, Paus R.J Dermatol SciRead the full storyquantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis
2019The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects.Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T.J Invest DermatolRead the full storyhair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes
2019Seborrheic dermatitis-Looking beyond Malassezia.Wikramanayake TC, Borda LJ, Miteva M, Paus R.Exp DermatolRead the full storychronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity
2019CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia.Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R.EMBO Mol MedRead the full storyhair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects
2019PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology.Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R.Exp. DermatolRead the full storyhair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia
2019Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage.Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M.J Eur Acad Dermatol VernereolRead the full storyhair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris
2019Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo.Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R.Skin Pharmacol PhysiolRead the full storyhair follicle, ex vivo, organ culture, glucocorticoid, hair cycle
2019Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways.Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X.J Dermatol SciRead the full storyhuman breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture
2019Frontiers in alopecia areata pathobiology research.Gilhar A, Britva RL, Keren A, Paus R.J Allergy Clin ImmunolRead the full storyhumanized mouse model, autoantigens, regulatory T cells, immune privilege
2019Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen.Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R.J Invest DermatolRead the full storyhuman hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease
2019Model-based approach to the design of pharmaceutical roller-compaction processes.Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J.Int J PharmRead the full storymathematical model, in-silico, ibuprofen formulations, iterative calibration
2019Comparing skin characteristics and molecular markers of xerotic foot skin between diabetic and non-diabetic subjects: An exploratory studyLechner A. , Akdeniz M. , Tomova-Simitchieva T. , Bobbert T. , Moga A. , Lachmann N., Blume-Peytavi U., Kottner J.Journal Of Tissue ViabilityRead the full storyDermatology; Diabetes mellitus; Diabetic foot; Dry skin; Molecular markers; Skin barrier, pharma
2019The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier IntegrityReynier M., Allart S., Goudounèche D., Moga A., Serre G., Simon M., Leprince C.Journal Of Investigative DermatologyRead the full storySkin, epidermal barrier, dermatology
2019Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and CorneodesmosinPin D., Pendaires V., Alassane Sk., Froment C., Amalric N., Cadiergues Mc., Serre G., Haftek M., Vidémont E., Simon M.Journal Of Histochemistry & CytochemistryRead the full storyatopic dermatitis, differentiation, keratinocyte, skin, veterinary medicine
2019Appearance of aging signs in differently pigmented facial skin by a novel imaging systemRemo Campiche, Solène Trevisan, Pierre Séroul, Anthony V Rawlings, Cyprien Adnet, Dominik Imfeld, Rainer VoegeliJ Cosmet DermatolRead the full storyanti‐aging, Black African skin, Caucasian skin, ColorFace®, Ethnic, facial imaging, pores, skintone, wrinkles
2019Facial skin mapping: from single point bio-instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin typesR Voegeli, J Gierschendorf, B Summers, A V RawlingsInt J Cosmet Sci.Read the full storyclaim substantiation, Epilobium fleischeri, microbiota, reference frames, skin care, skin microbiome
2019Cosmetics increase skin evenness: Evidence from perceptual and physical measuresCarlota Batres, Aurélie Porcheron, Julie Latreille, Magalie Roche, Frédérique Morizot, Richard RussellSkin Res TechnolRead the full storycosmetics, skin imaging
2019Three-dimensional maps of human skin properties on full face with shadows using 3-D hyperspectral imagingLou Gevaux, Cyprien Adnet, Pierre Séroul, Raphael Clerc, Alain Trémeau, Jean Luc Perrot, Mathieu HébertJ Biomed OptRead the full storySkin, 3D image processing, 3D acquisition
Cameras, Reflectivity, Hyperspectral imaging
Calibration, Chromophores, 3D scanning, Scattering
2019Bio-derived hydroxystearic acid ameliorates skin age spots and conspicuous poresR Schütz, A V Rawlings, E Wandeler, E Jackson, S Trevisan, J-M Monneuse, I Bendik, M Massironi, D ImfeldInt J Cosmet Sci.Read the full storyage spots, chemical synthesis, computer modelling, hydroxystearic acid, pores, skin physiology/structure
2018Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration.Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E.DifferentiationRead the full storyear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis
2018Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.Paus R, Bulfone-Paus S, Bertolini M.J Investig Dermatol Symp ProcRead the full storyhair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases
2018An efficient method for eccrine gland isolation from human scalp.Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R.Exp DermatolRead the full storyhair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining
2018NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types.Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R.J Invest DermatolRead the full storyhumanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition
2018Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue.Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R.Br J DermatolRead the full story3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa
2018Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris.Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R.J Invest DermatolRead the full storyhair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay
2018Prolactin as a candidate sebotrop(h)ic hormone?Langan EA, Hinde E, Paus R.Exp DermatolRead the full storyhuman dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing
2018A guide to studying human dermal adipocytes in situ.Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R.Exp DermatolRead the full storyquantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology
2018Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture.Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B.PLoS BiolRead the full storycell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model
2018Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion.Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F.J Invest DermatolRead the full storyhumanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals
2018Melatonin: A cutaneous perspective on its production, metabolism, and functions.Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R.J Invest DermatolRead the full storyhair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses
2018Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal.Foster AR, Nicu C, Schneider MR, Hinde E, Paus R.Arch Dermatol ResRead the full storyin vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy
2018Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases.Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R.Trends Mol MedRead the full storyhair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege
2018Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R.PLoS BiolRead the full storyhair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy
2018How UV light touches the brain and endocrine system through skin, and why.Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R.EndocrinologyRead the full storyenvironmental factors, UV radiation, body homeostasis, neuro-endocrine system
2018Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling.Alam M, Hernandez I, Paus R, Jimenez F.Br J DermatolRead the full storyanagen, catagen, telogen, methylene blue staining, hair cycle stage
2018Topically applied nicotinamide inhibits human hair follicle growth ex vivo.Haslam IS, Hardman JA, Paus R.J Invest DermatolRead the full storyorgan culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells
2018Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis?Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D.J Histochem CytochemRead the full storyskin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death
2018Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids?Ramot Y, Olah A, Paus R.Br J DermatolRead the full storyuman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling
2018iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata.Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.J AutoimmunRead the full storyhumanized mouse model, xenotransplants, lymphocytes, therapeutic potential
2018Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin.Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A.J Allergy Clin ImmunolRead the full storyhumanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions
2018Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium.Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R.J Invest DermatolRead the full storyex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes
2018Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling.Dobreva, A, Paus R, Cogan NG.Math Med BiolRead the full storymathematical modelling, anagen phase interruption, therapeutic targets
2018Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry.Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R.BiotechniquesRead the full storyhuman hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine
2018Bridging the "Dead hair"-"live follicle" divide in applied hair research.Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R.J Cosmet SciRead the full storysynopsis, mini-organ, hair shaft structure
2018Olfactory receptor OR2AT4 regulates human hair growth.Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R.Nat CommunRead the full storyex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy
2018A technique for more precise distinction between catagen and telogen human hair follicles ex vivo.Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F.J Am Acad DermatolRead the full storyex vivo organ culture, hair cycle stage, macroscopic analysis
2018Transcriptional programming of normal and inflamed human epidermis at single-cell resolution.Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ.Cell RepRead the full storycomputational analysis, single-cell RNAseq, keratinocyte
2018Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle.Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R.J Allergy Clin ImmunolRead the full storyex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata
2018Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex.Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC.Am J Hum GenetRead the full storywhole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase
2018The renaissance of human skin organ culture: A critical reappraisal.Zhou L, Zhang X, Paus R, Lu Z.DifferentiationRead the full storyex vivo, morphological analyses, gene silencing, assays
2018Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding?Langan EA, Fink T, Paus R.Arch Dermatol ResRead the full storyex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation
2018Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response.Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA.Biochem Biophys Res CommunRead the full storyhumanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte
2018SpectraCam® : A new polarized hyperspectral imaging system for repeatable and reproducible in vivo skin quantification of melanin, total hemoglobin, and oxygen saturationA Nkengne, J Robic, P Seroul, S Gueheunneux, M Jomier, K VieSkin Res TechnolRead the full story
hemoglobin, hyperspectral imaging, in vivo melanin quantification
2018Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression.Simonneau M, Frouin E, Huguier V, Jermidi C, Jégou JF, Godet J, Barra A, Paris I, Levillain P, Cordier-Dirikoc S, Pedretti N, Bernard FX, Lecron JC, Morel F, Favot L.Oncotarget.Read the full storycytokine; immunotherapy; oncostatin M; skin cancer; tumor microenvironment.
2018Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles.Daull P, Guenin S, Hamon de Almeida V, Garrigue JS.Mol Vis.Read the full storyinflammation, drug delivery, eye, wound healing
2018Clinical Efficacy of a Novel Two-Part Skincare System on Pollution-Induced Skin DamageMakino Et., Jain A., Tan P., Nguyen A., Moga A., Charmel C., Kadoya K., Cheng T., Mehta Rc.J Drugs DermatolRead the full storySkin aging, pollutants, environmental stress, skin care, oxidative stress, apoptose, inflammation, skin barrier
2018Cerebrovascular β-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched dietHur J., Mateo V., Amalric N., Babiak M., Béréziat G., Kanony-Truc C., Clerc T., Blaise R., Limon I.The Faseb JournalRead the full story12-HETE; cerebral amyloid angiopathy; docosahexaenoic acid; vascular smooth muscle cells, Alzheimer, mouse model, pharma
2018Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermisGarcia M, Morello E, Garnier J, Barrault C, Garnier M, Burucoa C, Lecron JC, Si-Tahar M, Bernard FX, Bodet CVirulenceRead the full storyBacterial pathogenesis; antimicrobial peptides; chemokines; cytokines; flagellin; human keratinocytes; type 2 secretion system; type 3 secretion system.
2017Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition.Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R.J Invest DermatolRead the full storyhuman hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes
2017Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM.Nat CommunRead the full storygeno-wide analysis, meta-analysis, hair follicle cycling, therapeutics
2017Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology.Jumper N, Hodgkinson T, Paus R, Bayat A.PLoS OneRead the full storysite-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling
2017Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation.Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A.J Invest DermatolRead the full storyHuman punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma
2017Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?Bertolini M, Rossi A, Paus R.Br J DermatolRead the full storyhair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis
2017Regulatory T cells in skin facilitate epithelial stem cell differentiation.Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD.CellRead the full storyimmune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata
2017Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling.Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ.HeliyonRead the full storyincisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling
2017Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H.Exp DermatolRead the full storyhuman keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair
2017Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS.BioessaysRead the full storyredox homeostasis, NRF2 activation, hair follicle pathologies
2017E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis.Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z.J Invest DermatolRead the full storyhuman skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy
2017Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix.Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus REur J Cell BiolRead the full storyhuman hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth
2017T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle.Oelert T, Gilhar A, Paus R.Exp DermatolRead the full storyhair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata
2017A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling.Jumper N, Hodgkinson T, Paus R, Bayat A.Acta Derm VenereolRead the full storylaser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour
2017Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R.Sci RepRead the full storyex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells
2017New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic SciencesJouravel G., Guénin S., Bernard Fx., Elfakir C., Bernard P., Himbert F.Cosmetics 2017, 4(52)Read the full storyLythrum salicaria L.; purple loosestrife; natural extract; vescalagin; skin barrier function; epidermis; differentiation; TGK; 3D model
2017Development of a new model of reconstituted mouse epidermis and characterization of its response to proinflammatory cytokines.Pohin M, Veaute C, Garnier J, Barrault C, Cronier L, Huguier V, Favot L, Mcheik J, Bernard FX, Lecron JC, Morel F, Jégou JF.J Tissue Eng Regen MedRead the full storycytokine; keratinocyte; reconstituted epidermis; skin inflammation; three-dimensional culture.
2017Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.Couderc E, Morel F, Levillain P, Buffière-Morgado A, Camus M, Paquier C, Bodet C, Jégou JF, Pohin M, Favot L, Garcia M, Huguier V, Mcheik J, Lacombe C, Yssel H, Guillet G, Bernard FX, Lecron JCPLoS OneRead the full storyNHEK, inflammation, psoriasis, cytokines
2017A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acneBouloc A., Roo E., Imko-Walczuk B., Moga A., Chadoutaud B., Dreno B.JeadvRead the full storyAcne Vulgaris, Emollients, Humans, Lipid Metabolism, Skin, Skin Care, dermatology, pharma
2017A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized StudyBouloc A., Roo E., Moga A., Chadoutaud B., Zouboulis Cc.Acta Dermato-VenereologicaRead the full storyhttps://jddonline.com/articles/clinical-efficacy-of-a-novel-two-part-skincare-system-on-pollution-induced-skin-damage-S1545961618P0975X/
2017Novel approaches to characterize age-related remodelling of the dermal-epidermal junction in 2D, 3D and in vivoV L Newton, R S Bradley, P Seroul, M Cherel, C E M Griffiths, A V Rawlings, R Voegeli, R E B Watson, M J SherrattSkin Res TechnolRead the full storyskin ageing, X-ray computed tomography, reflectance confocal microscopy, dermal-epidermal junction, photodamage, rete ridge, dermal papilla
2016Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization.Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ.Stem CellsRead the full storywound healing, transgenic mice, in vivo
2016An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target.Jumper N, Paus R, Bayat A.Plast Reconstr Surg Glob OpenRead the full storyskin biopsies, laser capture microdissection, epidermis
2016A Guide to studying human hair follicle cycling in vivo.Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV.J Invest DermatolRead the full storypre-clinical, xenograft, immuno-histochemistry
2016Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth.Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R.DevelopmentRead the full storygene expression, transcriptome, embryos, cell migration
2016Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice.Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR.DevelopmentRead the full storygene targeting, mouse line, in vivo, meibomian gland disease
2016p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis.Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z.J Invest DermatolRead the full storychip analysis, in vivo, therapeutic targeting, dermatoses
2016Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R.Br J DermatolRead the full storyhair follicle organ culture, immuno‐histomorphometry, autoimmune disorder
2016A primer for studying cell cycle dynamics of the human hair follicle.Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R.Exp DermatolRead the full storyimmuno-labelling, cell cycle, proliferation, apoptosis
2016Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue.Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A.J Invest DermatolRead the full storymolecular diagnostic, biomarker, immunohistochemistry, dermal scarring
2016Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R.Autoimmun RevRead the full storyxenografts, transplantation, SCID mice, therapeutic strategies
2016The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease.Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A.J Invest DermatolRead the full storylaser capture microdissection, microarray, luciferase assay, metabolism
2016The gut-skin axis in health and disease: A paradigm with therapeutic implications.O'Neill CA, Monteleone G, McLaughlin JT, Paus R.BioessaysRead the full storymicrobiota, signaling pathways, skin co‐morbidities
2016The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo.Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R.J Invest DermatolRead the full storyhuman scalp hair follicle, organ culture, hair cycle, translational human hair research
2016Exploring the "brain-skin connection": Leads and lessons from the hair follicle.Paus R.Curr Res Transl MedRead the full storyhuman hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin
2016Biology of the eyelash hair follicle: an enigma in plain sight.Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A.Br J DermatolRead the full storymini-organ culture, greying, cosmetic manipulation
2016Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis.Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E.PLoS GenetRead the full storysiRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias
2016Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit?Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R.Exp DermatolRead the full story3D imaging, scalp follicular units, skin appendages
2016Thyroid hormones enhance mitochondrial function in human epidermis.Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R.J Invest DermatolRead the full storyHuman skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function
2016Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis.Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R.Matrix BiolRead the full storyHair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane
2016Identification of new morphological differences between Chinese and Caucasian faces and influence of BMI on these characteristicsA Machard, M Jomier, D Hottelart, K ViéSkin Res TechnolRead the full storyCaucasian, Chinese, face morphology, BMI average, face ultrasound analysis, fringe projection
2016Rab11a Is Essential for Lamellar Body Biogenesis in the Human EpidermisReynier M. , Allart S. , Gaspard E. , Moga A. , Goudounèche D., Serre G., Simon M., Leprince C.Journal Of Investigative DermatologyRead the full storyCells, Cultured, Epidermis, metabolism, Gene Silencing, Homeostasis / genetics, Humans, Keratinocytes / cytology, Organelle Biogenesis, Sampling Studies, Tissue Culture Techniques,rab GTP-Binding Proteins / genetics*
2016Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff conditionJourdain R., Moga A., Vingler P., El Rawadi C., Pouradier F., Souverain L., Bastien P., Amalric N., Breton L.Arch Dermatol ResRead the full storyDandruff scalp; Lipids; Malassezia; Oxidative stress; Sebum; Squalene peroxide.
2016Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts.Mcheik JN, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, Morel F, Lecron JC, Bernard FX.J Tissue Eng Regen Med.Read the full storyburns; differentiation; foreskin; graft; keratinocytes; proliferation.
2016Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast.Régnacq M, Voisin P, Sere YY, Wan B, Soeroso VMS, Bernard M, Camougrand N, Bernard FX, Barrault C, Bergès T.Biochem Biophys Res Commun.Read the full storyAutophagy; Fatty acid; Fatty acid synthase; Lipid droplets; Rapamycin; Saccharomyces cerevisiae.
2016Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammationPohin M, Guesdon W, Mekouo AA, Rabeony H, Paris I, Atanassov H, Favot L, Mcheik J, Bernard FX, Richards CD, Amiaud J, Blanchard F, Lecron JC, Morel F, Jégou JF.Eur J Immunol.Read the full storyImiquimod · Keratinocyte · Oncostatin M · Psoriasis · Skin inflammation.
2015IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasomeRabeony H, Pohin M, Vasseur P, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F.Eur J Immunol.Read the full storyIL-1R; Imiquimod; MyD88; NLRP3 inflammasome; Skin inflammation.
2015A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groupsR Voegeli, A V Rawlings, P Seroul, B SummersInt J Cosmet Sci.Read the full storyethnic, facial colour mapping, skin barrier, skin hydration, stratum corneum, transepidermal water loss
2015Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor.Barrault C, Garnier J, Pedretti N, Cordier-Dirikoc S, Ratineau E, Deguercy A, Bernard FX.J Steroid Biochem Mol Biol.Read the full storyAndrogen; Apoptosis; Differentiation; Lipid; Receptor; Sebocyte.
2015IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells.Akil H., Abbaci A., Lalloué F., Bessette B., Costes Lm., Domballe L., Charreau S., Guilloteau K., Karayan-Tapon L., Bernard Fx., Morel F., Jauberteau Mo., Lecron Jc.PLoS ONE, 10(3)Read the full storyLung and intrathoracic tumors, Colorectal cancer, Apoptosis, Hepatocellular carcinoma, Cell proliferation, Gastric cancer, Phosphorylation, Renal cancer
2015Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitisLe Lamer M., Pellerin L., Reynier M., Cau L., Pendaires V., Leprince C., Mechin Mc., Serre G., Paul C., Simon M.Biol. Chem.Read the full storyatopic dermatitis, corneocytes, eczema, epidermal barrier, filaggrin, keratinocytes, skin inflammation
2015In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornificationPendaires V., Le Lamer M., Cau L., Hansmann B., Malaisse J., Kezic S., Serre G., Simon M.Cell Death And DiseaseRead the full storyskin, epidermis, filaggrin, corneocytes, 3D model
2014Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiationPendaires V., Malaisse J., Pellerin L., Le Lamer M., Nachat R., Kezic S., Schmitt Am., Paul C., Poumay Y., Serre G., Simon M.Journal Of Investigative DermatologyRead the full storyatopic dermatitis, epidermal barrier, keratinocye differentiation, filaggrin, RHE, 3D model, corneocyte, UV-B, environmental stress
2014Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M.Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou JF, Guillet G, Huguier V, Lecron JC, Bernard FX, Morel F.PLoS OneRead the full storyskin, keratinocyte, differeciation, epidermal barrier, inflammation
2014Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in childrenMcheik JN, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, Morel F, Bernard FX, Lecron JC.BurnsRead the full story3D model, epidermis, keratinocyte
2014Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspectiveMcheik Jn, et al.Plast Reconstr Surg Glob Open.Read the full storywound healing, keratinocyte, transplantation, sun burn, skin
2013Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression.Debiais-Delpech C., Godet J., Pedretti N., Bernard Fx., Irani J., Cathelineau X., Cussenot O. And Fromont G.Urologic OncologyRead the full storyprostate, cancer cells, proliferation
2013Contribution of IL-22 to Experimental Skin Inflammation.Lecron Jc., Paris I., Bernard Fx. And Morel F.Progress in Inflammation Research: ‘IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity’, Springer Basel, 305-317.Read the full storyskin inflammation, IL-22, interleukine, autoimmunity, inflammatory skin disease, psoriasis
2013Involvement of IL-1 and Oncostatin M in acanthosis associated to Hypertensive Leg Ulcer.Giot Jp., Paris I., Levillain P., Huguier V., Charreau S., Delwail A., Garcia M., Bernard Fx., Dagregorio G., Guillet G., Morel F., Lecron Jc. And Favot L.The American Journal of Pathology, 182(3):806-18Read the full storyHyper tensive leg ulcer, inflammatory disease, epidermis acanthosis, cytokine
2013Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts.Mcheik Jn., Barrault C., Pedretti N., Garnier J., Juchaux F., Levard G., Morel F., Lecron Jc., Bernard Fx.Journal of tissue engineering and regenerative medicineRead the full storykeratinocytes foreskin burns graft proliferation differentiation
2012Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and PsoriasisBernard FX, Morel F, Camus M, Pedretti N, Barrault C, Garnier J, Lecron JCJ Allergy (Cairo)Read the full storySkin, keratinocyte, immune cells, inflammation, atopic dermatitis, psoriasis, skin morphology, cytokines
2012Cystinosin is a Melanosomal Protein That Regulates Melanin Synthesis.Chiaverini C., Sillard L., Flori E., Ito S., Briganti S., Wakamatsu K., Fontas E., Berard E., Cailliez M., Cochat P., Foulard M., Guest G., Niaudet P., Picardo M., Bernard Fx., Antignac C., Ortonne Jp. And Ballotti R.The FASEB Journal, 26(9):3779-89Read the full storypigmentation, melanocytes, melanogenesis, tyrosinase, cytonosis
2012Immortalized sebocytes can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium.Barrault C., Dichamp I., Garnier J., Pedretti N., Juchaux F., Deguercy A., Agius G. And Bernard Fx.Experimental Dermatology, 21(4):314-6Read the full story3D model, differentiation, keratinocyte, sebocyte, skin
2012The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells.Lamiche C., Clarhaut J., Strale Po., Crespin S., Pedretti N., Bernard Fx., Naus C., Chen V., Foster L., Defamie N., Mesnil M., Debiais F. And Cronier L.Clinical & Experimental Metastasis, 29(2):111-22Read the full storyprostate, cancer cells, proliferation
2012siRNA-mediated allele-specific inhibition of mutant type VII collagen in dominant dystrophic epidermolysis bullosaPendaires V., Gasc G., Titeux M., Tonasso L., Mejía Je., Hovnanian A.Journal Of Investigative DermatologyRead the full storyatopic dermatitis, differentiation, keratinocyte, skin, veterinary medicine
2011Black patients of African descent and HLA-DRB1*15:03 frequency overrepresented in epidermolysis bullosa acquisitaZumelzu C., Le Roux-Villet C., Loiseau P., Busson M., Heller M., Aucouturier F., Pendaires V., Lièvre N; Pascal F., Brette M. D., Doan S., Charron D., Caux F., Laroche L., Petit A., Prost-Squarcioni C.Journal Of Investigative DermatologyRead the full storyAutoimmune disease, skin, skin of color, skin condition
2011Deimination of human filaggrin-2 promotes its proteolysis by calpain 1Hsu Cy., Henry J., Raymond Aa., Méchin Mc., Pendaires V., Nassar D., Hansmann B., Balica S., Burlet-Schiltz O., Schmitt Am., Takahara H., Paul C., Serre G., Simon M.The Journal Of Biological ChemistryRead the full storyCalpain, Differentiation, Mass Spectrometry (MS), Post-translational Modification, Protease, Skin, Corneocytes, Epidermis, Keratinocytes, Peptidylarginine Deiminase
2011Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study.Deloche C., Minondo Am., Bernard Ba., Bernerd F., Salas F., Garnier J. And Tancrède E.European Journal of Dermatology, 21(2):191-6Read the full storyskin ageing, dermal epidermal junction, C-xyloside, Laminin 332, α 6-integrin subunit
2011CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions.Ghannam S., Dejou C., Pedretti N., Giot Jp., Dorgham K., Boukhaddaoui H., Deleuze V., Bernard Fx., Jorgensen C., Yssel H. And Pène J.The Journal of Immunology, 186(3):1411-20Read the full storyInflammation, endothelium, skin cytokine, lymphocytes
2010Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns.Mcheik Jn., Barrault C., Bernard Fx. And Levard G.Burns, 36(8):1277-82Read the full storyskin burns, pediatric, foreskin keratinocytes, 2D model
2010Skin inflammation induced by the synergistic action of IL-17A, IL-22, OSM, IL-1α and TNFα recapitulates some features of psoriasis.Guillotteau K., Paris I., Pedretti N., Boniface K., Juchaux F., Huguier V., Guillet G., Bernard Fx., Lecron Jc. And Morel F.The Journal of Immunology, 184(9):5263 -5270Read the full storySkin, inflammation, cytokines, keratinocytes, in vitro model, psoriasis, transcriptional analysis
2010Immune reactivity to type VII collagen: implications for gene therapy of recessive dystrophic epidermolysis bullosaPendaires V., Gasc G., Titeux M., Leroux C., Vitezica Zg, Mejía Je., Décha A., Loiseau P., Bodemer C., Prost-Squarcioni C., Hovnanian A.Gene TherapyRead the full storySkin condition, collagen, immunity, sensitivity
2009Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.Guenou H., Nissan X., Larcher F., Feteira J., Lemaitre G., Saidani M., Del Rio M., Barrault C., Bernard Fx., Peschanski M., Baldeschi C. And Waksman G.The Lancet, 374(9703):1745-1753Read the full storyburns, graft, reconstructed epidermis, stem cells, preclinical study
2009Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils.Rahmoun M., Molès Jp., Pedretti N., Mathieu M., Fremaux I, Raison-Peyron N., Lecron Jc., Yssel H. And Pène J.Journal of Investigative Dermatology, 129(3):671-81Read the full storyskin, psoriasis, inflammation, keratinocytes, neutrophils, in vitro 2D model, reconstructed epidermis
2009Cultured keratinocyte cells from foreskin and future application for burns in children.Mcheik Jn., Barrault C., Vincent G., Grammatico F., Peci S., Garnier J., Bernard Fx., Deguercy A. And Levard G.Annales de chirurgie plastique et esthétique, 54(6):528-32Read the full storyburns, graft, foreskin keratinocytes, in vitro study
2008Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE).Dallas C., Gerbi A., Tenca G., Juchaux F. And Bernard Fx.Phytomedicine, 15(10):783-92Read the full storydietary supplement, lipolytic effect, lipolysis, adipocytes, ex vivo model, clinical study, sinetrol, cAMP phosphodiesterase
2008Keratinocytes as targets for cytokines in skin inflammation.Lecron Jc., Morel F., Boniface K. And Bernard Fx.Recent Advances in Skin Immunology", S. Saeland. Ed.Read the full story-
2008Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction.Saintigny G., Bernard Fx., Juchaux F., Pedretti N. And Mahé C.Experimental Dermatology, 17(9):788-9Read the full storydermal fibroblast, collagen, 2D model, skin aging, Hayflick sennescence model
2008A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosaMatthias Titeux M., Pendaires V., Tonasso L., Décha A., Bodemer C., Hovnanian A.Human MutationRead the full storySkin condition, collagen, immunity, sensitivity, MMP1, fibroblast
2007A role for T cell-derived interleukin 22 in psoriatic skin inflammation.Boniface K., Morel F., Pedretti N., Garcia M., Guignouard E., Guillet G., Dagregorio G., Yssel H., Bernard Fx., Delwail A., Nau F. And Lecron Jc.Clinical and Experimental Immunology, 150(3):407-15Read the full storycytokines, inflammation, psoriasis, skin disease, T cells
2007Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation.Boniface K., Diveu C., Morel F., Pedretti N., Froger J., Ravon E., Garcia M., Venereau E., Preisser L., Guignouard E., Guillet G., Dagregorio G., Pene J., Moles J-P., Yssel H., Chevalier S., Bernard Fx., Gascan H. And Lecron Jc.The Journal of Immunology, 178(7):4615-22Read the full storyskin inflammation, T lymphocytes, keratinocytes, psoriasis
2007Moclobemide attenuates anoxia and glutamate induced neuronal damage in vitro independently of interaction with glutamate receptors subtypes.Verleye M., Steinschneider R., Bernard Fx. And Gillardin Jm.Brain Research, 1138:30-38Read the full storyAnoxia, glutamate neurotransmission, neuroprotective, compound evaluation
2006In-vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cellsJourdain C, Tenca G, Deguercy A, Troplin P, Poelman DEur J Cancer Prev.Read the full storyprostate, cancer cells, proliferation
2005Keratinocytes as targets for IL-10-related cytokines : a putative role in psoriasis pathogenesis.Boniface K., Lecron Jc., Bernard Fx., Dagregorio G., Guillet G., Nau F. And Morel F.European Cytokine NetworkRead the full storycytokines, skin, keratinocyte, inflammation, psoriasis
2005Alternative (non-animal) methods for cosmetic testing: current status and future prospects.Gribaldo L., Gennari A., Blackburn K., Clemedson C., Deguercy A., Meneguz A., Pfaller W. And Ruhdel I.Alternatives to Laboratory Animals, 33 (S1) Chapter 3.1, Acute Toxicity: 27-34Read the full storyCosmetic testing, non-animal testing
2005Alternative (non-animal) methods for cosmetic testing: current status and future prospects.Liebsch M., Spielmann H., Pape W., Krul C., Deguercy A. And Eskes C.Alternatives to Laboratory Animals, 33(S1) Chapter 3.8, UV-induced Effects: 131-46Read the full storyCosmetic testing, non-animal testing
2005Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing.Bernard FX, Barrault C, Juchaux F, Laurensou C, Apert L.J Wound CareRead the full storyskin, fibroblast, dermis, cell proliferation, wound healing
2002Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis.Bernard Fx., Pedretti N., Rosdy M. And Deguercy A.Experimental Dermatology, 11(1):59-74Read the full storyskin, reconstructed epidermis, transcriptional analysis, 3D in vitro model, RHE
2000Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermisBernard FX, Barrault C, Deguercy A, De Wever B, Rosdy MCell Biol Toxicol.Read the full storyRHE, reconstructed epidermis, 3D model, skin, UVA, environmental stress, reconstructed tissue
2000Expression of type 1 5alpha-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic(R)): a new model for screening skin-targeted androgen modulatorsBernard FX, Barrault C, Deguercy A, de Wever B, Rosdy M.Int J Cosmet Sci.Read the full storyRHE, reconstructed epidermis, 3D model, skin, reconstructed tissue