Androgens are known to strongly regulate the sebaceous gland. Relationships with testosterone have been reported and little is known about the role of DHEA. We showed that the most potent intracellular androgen metabolite, dihydrotestosterone (DHT), induced AR translocation, specific transcripts such as ras-related dexamethasone induced 1 (RASD1) and lipogenesis/lipid storage. We used these parameters to assess the behaviour and activity of the two main circulating androgens TESTO and DHEA, in comparison with DHT, in this model.
Key Questions to Ask When Choosing a CRO
Cosmetics, Dermatology, Pharmacology, VeterinaryIn Vitro Testing in Cosmetics: Pros and Cons
Cosmetics_cat_publiHow are In Vitro Testing Methods Used for Cosmetics?
Cosmetics_cat_publiAtopic dermatitis
Atopic dermatitisSample and slide preparation
HistologyHistological staining
HistologyFacial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types
Cosmetics_cat_publi, Skin barrier and hydrationBehavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line.
Cosmetics_cat_publiInnate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiomePharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulationAndrogens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulationPollution and epigenetics: Histone H3 modifications in keratinocytes after exposure to urban dust and Benzo(a)pyrene
Cosmetics_cat_publi, Skin protection and immune defense systemRefined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Barrière cutanée et hydratation, Skin barrier and hydration, Veterinary medicine, Veterinary MedicineThe Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity
Cosmetics_cat_publiOncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression
DermatologieClinical Efficacy of a Novel Two-Part Skincare System on Pollution-Induced Skin Damage
Cosmetics_cat_publiPseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis
Cosmétique, Microbiome cutané, Skin microbiomeAnti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
Cosmetics_cat_publi, Inflammation, PharmacologyCerebrovascular β-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet
Pharmacologie, PharmacologyNew Biological Activities of Lythrum salicaria L.
Cosmetics_cat_publi, Skin barrier and hydration