Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

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The study aimed to evaluate the tolerance, performance and effect on hair lipids and skin hydration of a protocol combining applications of one shampoo and subsequent mousses containing plant extracts (Ophytrium and Seboliance) in dogs with an undiagnosed chronic greasy keratinisation disorder.

Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

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Erythemato-ceruminous otitis externa (ECOE) is the most common type of otitis in dogs and is generally associated with bacterial and/or yeast infections.

Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results

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Atopic dermatitis is a form of allergy of genetic origin accompanied by itching, during which the animal more easily develops allergies to environmental factors, usually pollen and dust mites.

Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells

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Besides actions including their venotonic, anti-inflammatory, and anti-oxidant effects, venoactive drugs are expected to act on edema via their action on lymphatics.

Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study

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Conjunctivitis in atopic dogs has already been described yet is rarely observed, and likely underdiagnosed in practice.
Effets sur les signes cliniques, les lipides et les facteurs d'hydratation des applications combinées de shampooing et de mousse contenant de l'Ophytrium et du Seboliance chez les chiens atteints de séborrhée

Effets sur les signes cliniques, les lipides et les facteurs d’hydratation des applications combinées de shampooing et de mousse contenant de l’Ophytrium et du Seboliance chez les chiens atteints de séborrhée

Les performances du shampooing et des applications ultérieures de mousse ont été évaluées chez des chiens atteints de séborrhée. Les applications d'un shampooing et de mousses sans rinçage ont permis une amélioration significative...
Evaluation of mean inhibition - canine whole bool model

Évaluation des effets anti-inflammatoires et immunomodulateurs d’un produit sur un modèle in vitro de sang total canin

Modèles canins in vitro

Modèles canins in vitro 2D et 3D

Évaluation de l‘effet d’une molécule de référence sur un modèle d’Épiderme Canin Reconstruit atopique (RCE-AD)

A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coats

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Dog Skin - Epidermal Cornification Proteins

Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin

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Filaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis.
Tg2576 Alzheimer

Cerebrovascular β-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet

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Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis.

Biosimilaires

Apparue dans les années 1980, la notion de biosimilaire désigne un produit biologique identique en tout point (forme et substance pharmaceutique, caractéristiques physicochimiques et biologiques) à un médicament biologique original (vaccin, anticorps, facteur de croissance, etc.) déjà commercialisé et dont le brevet est expiré. La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques
autophagy

Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast

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Cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.

IL22/IL-22R pathway induces cell survival in human glioblastoma cells

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Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases.

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

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This study highlights the precise role of cytokines in the skin inflammatory response (psoriasis). IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
HNF1β prostate cancer

Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression

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Genome-wide association studies have identified variants at multiple loci associated with prostate cancer (PCa) risk. Some of these loci include candidate susceptibility genes, such as MSMB, HNF1β, and C-terminal-binding protein (CtBP2). Except for MSMB, the clinicopathological significance of these genes has not been investigated. We therefore aimed to analyze their expression in PCa tissues, in relation with tumor progression and aggressiveness.

Contribution of IL22 to experimental skin inflammation

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Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.

Involvement of IL-1 and Oncostatin M in acanthosis associated with hypertensive leg ulcer

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Hypertensive leg ulcer (HLU) is an inflammatory disease characterized by intense pain, alteration of vascularization, and skin necrosis. The optimal treatment relies on surgical removal of necrotic tissues covered by a split-skin graft.

The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells

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We investigated the effect of the increased Cx43 expression, by retroviral infection, on the metastatic behaviour of two well-characterized cell lines (PC-3 and LNCaP) representing different stages of PCa progression. It appeared that Cx43 differently behaved in those cell lines and induced different phenotypes.