
LABORATÓRIO DE PESQUISA CONTRATUAL
Farmacologia in vitro, engenharia celular, bioanálise, desenvolvimento de protocolo

DERMATOLOGIA
Testes de eficácia e modelos in vitro para pesquisa pré-clínica: psoríase, dermatite atópica, cicatrizes, acne, alopecia, pigmentação, etc.
MAIS DE 300 TESTES DE EFICÁCIA in vitro

COSMÉTICO
Estudos de eficácia in vitro e ex vivo de produtos cosméticos: pele oleosa, pele seca, hidratação, envelhecimento da pele, pigmentação, etc.
MAIS DE 300 TESTES DE EFICÁCIA COSMÉTICA

FARMACOLOGIA
Estudos de eficácia in vitro e ex vivo de produtos farmacêuticos: imunoinflamação, neurobiologia, medicina veterinária
CONSULTE O NOSSO CATÁLOGO DE TESTES in vitro
POSTS E PUBLICAÇÕES
Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm
Dermatologie, Dermatology, PigmentationComparative analysis of original face and skin-warped average face images for the scoring of skin attributes
Cosmetics, Cosmetics, CosmétiqueNeryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Expression de gènes, Skin barrier and hydrationMalassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
Dermatologie, Dermatology, Hair follicleEvaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers
Cosmetics, Cosmetics, CosmétiqueClinical Evaluation of Indian Sandalwood Oil and Its Protective Effect on the Skin against the Detrimental Effect of Exposome
Cosmetics, CosmeticsAnalysis of correlation and construction of a predictive model of skin transparency using parameters from digital images of the face
Cosmetics, Cosmetics, CosmétiqueA novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke
Cosmetics, Cosmetics, CosmétiqueAnti-pollution effects of two antioxidants and a chelator-Ex vivo electron spin resonance and in vivo cigarette smoke model assessments in human skin
CosmeticsMetrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
Cosmetics, DermatologyType-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo
PigmentationUsing Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome, Skin microbiomeProfiling TLR agonist activity in keratinocytes and link to bacteria-induced innate immunity activation
Cosmetics, Microbiome cutané, Skin microbiomeFacial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types
Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Skin barrier and hydrationBehavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line.
CosmeticsInnate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiomePharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulationAndrogens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulationPollution and epigenetics: Histone H3 modifications in keratinocytes after exposure to urban dust and Benzo(a)pyrene
Cosmetics, Cosmetics, Cosmétique, Skin protection and immune defense systemRefined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Barrière cutanée et hydratation, Skin barrier and hydration, Veterinary medicine, Veterinary MedicinePseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis
Cosmétique, Microbiome cutané, Skin microbiomeAnti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
Cosmetics, Inflammation, PharmacologyEffects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
Cosmetics, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation, Skin protection and immune defense systemPhysiology and functions of the sebaceous gland
Acne, Sebaceous gland regulation, Skin barrier and hydrationA Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study
Cosmetics, Cosmetics, Cosmétiquein vitro modeling of skin photoaging: development of evaluation tools for cosmetics
Cosmetics, Skin ageingDevelopment of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
Cell and tissue engineering, Skin ageingRab11a Is Essential for Lamellar Body Biogenesis in the Human
Barrière cutanée et hydratation, Skin barrier and hydrationAndrogens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
Acne, Cell and tissue engineering, Sebaceous gland regulationImmortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
Acne, Cell and tissue engineering, Sebaceous gland regulationEffect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
Cosmetics, Cosmétique, Skin ageingLipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE)
Cosmetics, CosmétiqueReduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
Cosmetics, Cosmétique, Skin ageingAlternative (non-animal) methods for cosmetic testing: current status and future prospects – UV-induced effects
Cosmetics, Cosmétique, Safety and toleranceAlternative (non-animal) methods for cosmetic testing: current status and future prospects – Acute toxicity
Cosmetics, Cosmétique, Safety and toleranceComparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis
Cosmetics, Cosmétique, Epidermal regenerationDevelopment of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis
Safety and toleranceReliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm
Dermatologie, Dermatology, PigmentationAutologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants
Atopic dermatitis, Dermatite atopique, Pharmacologie, PharmacologyMalassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
Dermatologie, Dermatology, Hair follicleMetrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
Cosmetics, DermatologyUsing Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome, Skin microbiomeInnate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiomePharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulationAndrogens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulationPhysiology and functions of the sebaceous gland
Acne, Sebaceous gland regulation, Skin barrier and hydrationInterleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
PsoriasisA skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
Acné, AcneImiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome
PsoriasisAndrogens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
Acne, Cell and tissue engineering, Sebaceous gland regulationStudy of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children
Wound healingEpidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective
Wound healingInhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M
Inflammation, PsoriasisForeskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts
Wound healingKeratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis
Atopic dermatitis, Dermatite atopique, PsoriasisImmortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
Acne, Cell and tissue engineering, Sebaceous gland regulationQuantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns
Wound healingSkin inflammation induced by the synergistic action of IL17A, IL22, OSM, IL1α and TNFα recapitulates some features of psoriasis
PsoriasisHuman embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
Cell and tissue engineering, Dermatology, Pharmacology, Wound healingKeratinocytes as targets for cytokines in skin inflammation
Acne, Atopic dermatitis, Dermatology, PsoriasisCytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils
PsoriasisOSM (Oncostatin M) secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation
PsoriasisKeratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis
PsoriasisStimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing
Wound healingIL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
Inflammation, PsoriasisExpression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis
Acne, DermatologyAutologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants
Atopic dermatitis, Dermatite atopique, Pharmacologie, PharmacologyPerformance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts
Veterinary medicine, Veterinary MedicineDermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes
Inflammation, Pharmacologie, PharmacologyClinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa
Veterinary Medicine, Veterinary medicineMultiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results
Veterinary medicine, Veterinary MedicineLymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
Pharmacologie, PharmacologySurvey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study
Veterinary Medicine, Veterinary medicineEffects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs
Veterinary medicineEvaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models
Veterinary medicineAddress
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