LABORATÓRIO DE PESQUISA CONTRATUAL

Farmacologia in vitro, engenharia celular, bioanálise, desenvolvimento de protocolo

Nos tests in vitro en dermatologie

DERMATOLOGIA

Testes de eficácia e modelos in vitro para pesquisa pré-clínica: psoríase, dermatite atópica, cicatrizes, acne, alopecia, pigmentação, etc.

MAIS DE 300 TESTES DE EFICÁCIA in vitro

cosmétique

COSMÉTICO

Estudos de eficácia in vitro e ex vivo de produtos cosméticos: pele oleosa, pele seca, hidratação, envelhecimento da pele, pigmentação, etc.

MAIS DE 300 TESTES DE EFICÁCIA COSMÉTICA

FARMACOLOGIA

Estudos de eficácia in vitro e ex vivo de produtos farmacêuticos: imunoinflamação, neurobiologia, medicina veterinária

CONSULTE O NOSSO CATÁLOGO DE TESTES in vitro

SUA CRO DE FARMACOLOGIA CELULAR E MOLECULAR
BIOENSAIOS, MODELOS E SOLUÇÕES EM in vitro & ex vivo

COSMÉTICOS

Experiência em P&D em cosméticos

DERMATOLOGIA

Experiência em P&D em dermatologia

FARMACOLOGIA

Experiência em P&D em farmacologia

SOLUÇÕES PERSONALIZADAS DE P&D FAÇA DA NOSSA EXPERIÊNCIA O SEU SUCESSO

Sceening virtual in silico

Caracterização e biopredição para obter informações sobre a atividade biológica das moléculas candidatas e sobre as suas propriedades bioquímicas

estudos de farmacologia in vitro

Avaliação, caracterização, mecanismo de ação e prova de conceito:
serviços personalizados de farmacologia in vitro

Análise histológica e imuno-histoquímica

Pesquisa funcional e contínua em tecidos e biópsias: coloração (tricromo e especial), imuno-histoquímica, imunofluorescência

Análise de transcriptoma

Um departamento exclusivo para análise de transcriptoma de mRNAS e microRNAS: RT-qPCR, PCRarrays, microarrays

Química Analítica

Caracterização bioquímica de compostos e implementação de métodos analíticos. Estudos iniciais de farmacodinâmica e farmacocinética e avaliação das interações PK/PD

Bioanálise de amostras clínicas não invasivas

Resultados clínicos objetivos e independentes de uma equipe de voluntários. Correlação com dados obtidos in vitro.

POSTS E PUBLICAÇÕES

SkinCam Pro : New image capture device for clinical evaluation of the skin

Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm

Dermatologie, Dermatology, Pigmentation

SpectraCam & SpectraFace – Study invisible parameters of the skin

Lip color measurement: A new hyperspectral imaging device

Cosmetics, Cosmetics

Eyelashcam – A dedicated camera for the eye area

Portable camera Skincam

SkinCam Portable camera for nomadic use

Newtone Technologies - clinical imaging - skin and hair appearance - ColorFace

Face imaging system – ColorFace

Cosmetics, Dermatology

Comparative analysis of original face and skin-warped average face images for the scoring of skin attributes

Cosmetics, Cosmetics, Cosmétique

Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier

Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Expression de gènes, Skin barrier and hydration

Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff

Dermatologie, Dermatology, Hair follicle

Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers

Cosmetics, Cosmetics, Cosmétique

Clinical Evaluation of Indian Sandalwood Oil and Its Protective Effect on the Skin against the Detrimental Effect of Exposome

Cosmetics, Cosmetics

Analysis of correlation and construction of a predictive model of skin transparency using parameters from digital images of the face

Cosmetics, Cosmetics, Cosmétique

Bioanalysis of non-invasive samples

Cosmetics, Dermatologie

A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke

Cosmetics, Cosmetics, Cosmétique

Anti-pollution effects of two antioxidants and a chelator-Ex vivo electron spin resonance and in vivo cigarette smoke model assessments in human skin

Metrology

Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm

Cosmetics, Dermatology

Bioanalysis of non-invasive clinical samples

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

How In Silico Screening Can Guide Product Development in Cosmetics

Cosmetics, in silico

BACT-0003_Bacterial growth #1

The Relationship Between Microbiology Testing and the Skin Microbiota

Cosmetics, Skin microbiome

Using Reconstructed Human Epidermis model in Skin Microbiome Research

Skin microbiome, Skin microbiome

Canities and hair pigmentation

Cosmetics, Hair follicle

in vitro and ex vivo assays: skin barrier and hydration

Cosmetics Claims Substantiation: What You Need to Know

Profiling TLR agonist activity in keratinocytes and link to bacteria-induced innate immunity activation

Cosmetics, Microbiome cutané, Skin microbiome

Photometry

What is the Role of Skin Care Product Testing Labs in Efficacy Testing?

Photometry

Is In Vitro a Good Alternative to Animal Testing for Efficacy Testing of Cosmetics

in vitro and ex vivo assays: skin ageing

How is In Vitro Testing Done? Improve Quality & Safety of Cosmetics

Photometry

In Vitro Testing in Cosmetics: Pros and Cons

Photometry

How are In Vitro Testing Methods Used for Cosmetics?

Cosmetics, Cosmetics

Facial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types

Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Skin barrier and hydration

Behavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line.

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome

Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Acne, Sebaceous gland regulation

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation

in vitro and ex vivo assays: skin protection and immune defense system

Pollution and epigenetics: Histone H3 modifications in keratinocytes after exposure to urban dust and Benzo(a)pyrene

Cosmetics, Cosmetics, Cosmétique, Skin protection and immune defense system

Dog Skin - Epidermal Cornification Proteins

Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin

Barrière cutanée et hydratation, Skin barrier and hydration, Veterinary medicine, Veterinary Medicine

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

Cosmétique, Microbiome cutané, Skin microbiome

Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles

Cosmetics, Inflammation, Pharmacology

New Biological Activities of Lythrum salicaria L.

Cosmetics, Skin barrier and hydration

lipid

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

Cosmetics, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation, Skin protection and immune defense system

Acne vulgaris: physiopathology and cell mechanisms

Acne, Sebaceous gland regulation

Physiology and functions of the sebaceous gland

Acne, Sebaceous gland regulation, Skin barrier and hydration

Hair: Follicle, Associated Structures and Growth

Cosmetics, Hair follicle

Skin care complex

A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study

Cosmetics, Cosmetics, Cosmétique

New biological effects of Aphloïol

Cosmetics, Cosmétique, Skin barrier and hydration

skin photoaging irradiations

in vitro modeling of skin photoaging: development of evaluation tools for cosmetics

Cosmetics, Skin ageing

ageing reconstructed epidermis

Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds

Cell and tissue engineering, Skin ageing

Rab11

Rab11a Is Essential for Lamellar Body Biogenesis in the Human

Barrière cutanée et hydratation, Skin barrier and hydration

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Acne, Cell and tissue engineering, Sebaceous gland regulation

Cystinosin is a melanosomal protein that regulates melanin synthesis

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Acne, Cell and tissue engineering, Sebaceous gland regulation

Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study

Cosmetics, Cosmétique, Skin ageing

Lipolytic

Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE)

Cosmetics, Cosmétique

tensin1

Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction

Cosmetics, Cosmétique, Skin ageing

UV-induced

Alternative (non-animal) methods for cosmetic testing: current status and future prospects – UV-induced effects

Cosmetics, Cosmétique, Safety and tolerance

acute toxicity

Alternative (non-animal) methods for cosmetic testing: current status and future prospects – Acute toxicity

Cosmetics, Cosmétique, Safety and tolerance

gene expression

Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis

Cosmetics, Cosmétique, Epidermal regeneration

phototoxicity

Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis

Safety and tolerance

Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm

Dermatologie, Dermatology, Pigmentation

Newtone Technologies - clinical imaging - skin and hair appearance - ColorFace

Face imaging system – ColorFace

Cosmetics, Dermatology

Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants

Atopic dermatitis, Dermatite atopique, Pharmacologie, Pharmacology

Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff

Dermatologie, Dermatology, Hair follicle

Metrology

Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm

Cosmetics, Dermatology

BACT-0003_Bacterial growth #1

Microbiota vs. Microbiome: What’s the Difference?

Skin microbiome

Using Reconstructed Human Epidermis model in Skin Microbiome Research

Skin microbiome, Skin microbiome

Atopic dermatitis

Atopic dermatitis

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome

Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Acne, Sebaceous gland regulation

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation

Various forms of acne vulgaris

Acne vulgaris: Origins, symptoms and current treatments

Acne vulgaris: physiopathology and cell mechanisms

Acne, Sebaceous gland regulation

Physiology and functions of the sebaceous gland

Acne, Sebaceous gland regulation, Skin barrier and hydration

Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

Adapalene and benzoyl peroxide

A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

granulation wound healing

Wound healing, granulation phase and maturation phase

Wound healing, hemostasis phase and inflammatory phase

Wound healing, overview

imiquimod

Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Acne, Cell and tissue engineering, Sebaceous gland regulation

Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children

Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

Inflammation, Psoriasis

Contribution of IL22 to experimental skin inflammation

Inflammation, Psoriasis

Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts

Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis

Atopic dermatitis, Dermatite atopique, Psoriasis

cytokine

Atopic dermatitis – initiation and chemokines activation step

Atopic dermatitis

atopic dermatitis

Atopic dermatitis – immune response and skin lesions

Atopic dermatitis

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Acne, Cell and tissue engineering, Sebaceous gland regulation

Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns

Skin inflammation induced by the synergistic action of IL17A, IL22, OSM, IL1α and TNFα recapitulates some features of psoriasis

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

Cell and tissue engineering, Dermatology, Pharmacology, Wound healing

burns

Cultured keratinocyte cells from foreskin and future application for burns in children

skin inflammation

Keratinocytes as targets for cytokines in skin inflammation

Acne, Atopic dermatitis, Dermatology, Psoriasis

CEACAM1

Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils

interleukin 22

A role for T cell-derived interleukin 22 in psoriatic skin inflammation

OSM

OSM (Oncostatin M) secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation

IL10

Keratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis

lipidocolloid dressing

Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing

IL-22

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

Inflammation, Psoriasis

5-alpha-reductase

Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis

Acne, Dermatology

Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants

Atopic dermatitis, Dermatite atopique, Pharmacologie, Pharmacology

Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

Veterinary medicine, Veterinary Medicine

Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes

Inflammation, Pharmacologie, Pharmacology

Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

Veterinary Medicine, Veterinary medicine

Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results

Veterinary medicine, Veterinary Medicine

Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells

Pharmacologie, Pharmacology

Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study

Veterinary Medicine, Veterinary medicine

Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs

Veterinary medicine

Evaluation of mean inhibition - canine whole bool model

Evaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models

Veterinary medicine