QIMA Life Sciences has many in vitro or ex vivo models at your disposal:
- normal human dermal fibroblasts (NHDF)
- dermal equivalent (DE)
- normal human epidermal keratinocytes (NHEK)
- reconstructed human epidermis (RHE)
- full thickness reconstructed skin (FTSK)
- skin explants (ex vivo)
on which we can evaluate the effect of active compounds or formulations on:
- dermis cohesion and firmness (lattice contraction)
- synthesis and expression of extracellular matrix components:
- collagens (collagen I, collagen III), elastin, fibronectin, etc.
- proteoglycans, glycoaminoglycans and hyaluronic acid
- proteases (MMPs)
- collagens (collagen I, collagen III), elastin, fibronectin, etc.
- dermo-epidermal junction proteins (integrins, laminin V, collagen IV, collagen VII)
- cell adhesion proteins (desmogleins, etc.)
- cell renewal (proliferation, differentiation)
Here are a few examples among all assays proposed by QIMA Life Sciences in the field of skin firmness and cohesion:
