https://qima-lifesciences.com/wp-content/uploads/2020/08/mw_Metrology.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2020-08-25 10:27:242020-08-25 10:27:24Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
According to the International Bureau of Weights and Measurements, metrology, the study of measurement, is becoming an essential aspect of all industries today in creating value.
https://qima-lifesciences.com/wp-content/uploads/2019/08/5897-1.jpg 453 640 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2020-01-14 16:05:162020-06-11 17:13:27Microbiota vs. Microbiome: What’s the Difference?
What is the difference between microbiota vs. microbiome? Why are they important to human skin? What is the Skin Microbiota test? Learn more here.
https://qima-lifesciences.com/wp-content/uploads/2019/03/190328_Vignettes_Microbiome_EN.jpg 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-12-11 11:45:282019-12-11 12:26:10Using Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome research is developing rapidly. Are you up to date? Find out why 3D skin models are an important development in skin microbiome research.
https://qima-lifesciences.com/wp-content/uploads/2018/10/2004-1-e1568060512640.jpg 368 640 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2019-09-22 10:44:282019-10-20 16:49:325 Key Questions to Ask When Choosing a Preclinical Dermatology CRO
https://qima-lifesciences.com/wp-content/uploads/2013/04/Mw-Dermatite-atopique.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2019-07-31 11:33:042019-11-12 17:35:31Atopic dermatitis
AD is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to 25% of the population.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster1_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:542019-11-12 17:58:17Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster3_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:122019-11-12 17:36:48Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
We analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Androgens are key regulators of sebaceous function... A link between mTOR and androgen signaling has previously been reported...as well as a link between these processes and lipid synthesis...Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.
https://qima-lifesciences.com/wp-content/uploads/2017/11/Acné-généralité-image-à-la-une-_-EN.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-29 09:31:592019-11-12 14:28:03Acne vulgaris: Origins, symptoms and current treatments
Acne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.
https://qima-lifesciences.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-29 09:30:252019-09-13 07:40:20Acne vulgaris: physiopathology and cell mechanisms
Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes). QIMA Life Sciences has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.
https://qima-lifesciences.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-28 09:24:342019-11-07 15:45:07Physiology and functions of the sebaceous gland
The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.
https://qima-lifesciences.com/wp-content/uploads/2017/08/IL-17A.png 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-07-14 09:37:162019-08-01 15:20:02Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.
https://qima-lifesciences.com/wp-content/uploads/2017/05/mw_Adapalene-and-benzoyl-peroxide.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-05-01 13:27:372021-08-30 13:28:10A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
Acne in adult women is an increasing reason for dermatological consultations.
https://qima-lifesciences.com/wp-content/uploads/2016/11/mw_SMA.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-12 15:36:082019-09-13 22:08:09Wound healing, granulation phase and maturation phase
The third phase of wound healing, consisting in the replacement of the provisional fibrin matrix with granulation tissue once the wound has been debrided, includes several sub-phases: re-epithelialization, fibroplasia, collagen deposition and angiogenesis.
https://qima-lifesciences.com/wp-content/uploads/2016/11/mw_blood-cells-cicatrisation-inflammation-AdobeStock_117910248.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-10 15:40:392019-09-13 22:14:03Wound healing, hemostasis phase and inflammatory phase
The inflammatory phase is characterized by the sequential infiltration of polymorphonuclear neutrophils (PMNs), monocytes/macrophages and lymphocytes. IL-8 facilitates PMNs migration from surrounding blood vessels.
https://qima-lifesciences.com/wp-content/uploads/2016/03/pf_Cicatrisation-Adobe.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-09 15:45:552019-09-13 22:25:57Wound healing, overview
Wound healing is a complex and dynamic process of restoring skin cellular structures and tissue layers that involves multiple components: differentiated cells , stem cells , hair follicles, extracellular matrix (ECM) proteins, cytokines networks, microRNAs , blood vessels, nerves and mechanical forces.
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_imq-induced-skin-inflammation.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-07-24 17:30:202018-10-24 21:56:11Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome
The pathogenesis of inflammatory skin diseases such as psoriasis involves the release of numerous proinflammatory cytokines, including members of the IL-1 family. Here we report overexpression of IL-1α, IL-1β, and IL-1 receptor antagonist mRNA, associated to expression of IL-23p19, IL-17A, and IL-22 in skin cells
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662  constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues.
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_study-of-proliferation-and-3D-epidermal-reconstruction-from-foreskin.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2014-09-16 16:18:492018-10-24 21:59:38Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children
Our studies highlight the potential of foreskin tissue for autograft applications in boys. A suitable alternative donor site for autologous cell transplantation in female paediatric burn patients remains an open question in our department. We tested the hypothesis that in vitro studies and RHE reconstructive capacities of cells from different body sites can be helpful to select an optimal site for keratinocyte isolation before considering graft protocols for girls.
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_epidermal-healing-in-burns.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2014-09-07 16:13:052018-10-24 21:59:50Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective
In the contexte of skin graft, cell suspensions transplanted directly to the wound is an attractive process, removing the need for attachment to a membrane before transfer and avoiding one potential source of inefficiency. Choosing an optimal donor site containing cells with high proliferative capacity is essential for graft success in burns.