Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants
Atopic dermatitis, Dermatite atopique, Pharmacologie, PharmacologyAtopic dermatitis (AD) is one of the most common, as yet incurable chronic inflammatory skin diseases, which occurs in distinct endotypes and shows increasing prevalence.
Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
Dermatologie, Dermatology, Hair follicleDandruff is a common scalp disorder with multiple microbial and host-related factors contributing to its aetiology, including alterations in scalp sebum.
Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
Cosmetics, DermatologyAccording to the International Bureau of Weights and Measurements, metrology, the study of measurement, is becoming an essential aspect of all industries today in creating value.
Microbiota vs. Microbiome: What’s the Difference?
Skin microbiomeWhat is the difference between microbiota vs. microbiome? Why are they important to human skin? What is the Skin Microbiota test? Learn more here.
Using Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome, Skin microbiomeSkin microbiome research is developing rapidly. Are you up to date? Find out why 3D skin models are an important development in skin microbiome research.
Atopic dermatitis
Atopic dermatitisAD is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to
25% of the population.
Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiomeAcne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.
Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulationWe analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.
Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulationAndrogens are key regulators of sebaceous function... A link between mTOR and androgen signaling has previously been reported...as well as a link between these processes and lipid synthesis...Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.
Acne vulgaris: Origins, symptoms and current treatments
AcneAcne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.
Acne vulgaris: physiopathology and cell mechanisms
Acne, Sebaceous gland regulationAcne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes).
QIMA Life Sciences has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.
Physiology and functions of the sebaceous gland
Acne, Sebaceous gland regulation, Skin barrier and hydrationThe sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.
Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
PsoriasisAcute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.
A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
Acné, AcneAcne in adult women is an increasing reason for dermatological consultations.
Wound healing, granulation phase and maturation phase
Wound healingThe third phase of wound healing, consisting in the replacement of the provisional fibrin matrix with granulation tissue once the wound has been debrided, includes several sub-phases: re-epithelialization, fibroplasia, collagen deposition and angiogenesis.
Wound healing, hemostasis phase and inflammatory phase
Wound healingThe inflammatory phase is characterized by the sequential infiltration of polymorphonuclear neutrophils (PMNs), monocytes/macrophages and lymphocytes. IL-8 facilitates PMNs migration from surrounding blood vessels.
Wound healing, overview
Wound healingWound healing is a complex and dynamic process of restoring skin cellular structures and tissue layers that involves multiple components: differentiated cells , stem cells , hair follicles, extracellular matrix (ECM) proteins, cytokines networks, microRNAs , blood vessels, nerves and mechanical forces.
Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome
PsoriasisThe pathogenesis of inflammatory skin diseases such as psoriasis involves the release of numerous proinflammatory cytokines, including members of the IL-1 family. Here we report overexpression of IL-1α, IL-1β, and IL-1 receptor antagonist mRNA, associated to expression of IL-23p19, IL-17A, and IL-22 in skin cells
Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
Acne, Cell and tissue engineering, Sebaceous gland regulationIn order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662 [17] constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues.