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ACNE

Acne is a chronic inflammatory pathology of the pilosebaceous follicle under hormonal dependence that includes:

  • abnormal increase of  sebaceous lipid production (sebum)
  • formation of microcomedones due to an abnormal epidermal differentiation, a likely consequence of abnormal androgen (testosterone) metabolism
  • accumulation of peroxidized lipids on the surface (blackheads) or inside the comedo (whitehead)
  • formation of infectious and non-infectious inflammatory lesions and a skin wound healing process

Acne: in vitro models and assays

QIMA Life Sciences has many in vitro or ex vivo models related to acne at your disposal:

  • Human sebocytes: SEBO662 and SEBO662AR cell lines
  • Normal human epidermal keratinocytes (NHEK)
  • Normal human dermal fibroblasts (NHDF)
  • Human  follicle dermal papilla cells (HFDPC)
  • Reconstructed human epidermis (RHE)

QIMA Life Sciences provides you with a range of innovative in vitro pharmacological models and assays, more particularly dedicated to the evaluation of the pharmacological efficacy (screening, profiling, proof-of-concept) of your products (APIs, biosimilars, fomulations, medical devices):

  • Sebaceous gland regulation and hyperseborrhea
  • Androgen metabolism
  • Abnormal epidermal differentiation
  • Lipid peroxidation
  • Inflammatory, lesional or microbial response
  • Infection, immune system and skin defenses

Here are a few examples among all assays proposed by QIMA Life Sciences in the field of acne:

  • Beta defensin 2 release

    NHEK, antimicrobial peptide release (basal)

    1.00€
    Add to cart Show Details
  • Lipid content

    SEBO662AR, lipogenesis (lipogenic and androgenic stimulation)

    1.00€
    Add to cart Show Details
  • Lipid content

    SEBO662AR, lipogenesis (testosterone stimulation)

    1.00€
    Add to cart Show Details
  • DHT testosterone ratio

    Sebocytes, testosterone metabolism & 5- alpha reductase activity (basal)

    1.00€
    Add to cart Show Details
Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

Acne: posts and publications

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome

Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster1_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:542019-11-12 17:58:17Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Acne, Sebaceous gland regulation

We analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster3_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:122019-11-12 17:36:48Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation

Androgens are key regulators of sebaceous function… A link between mTOR and androgen signaling has previously been reported…as well as a link between these processes and lipid synthesis…Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Various forms of acne vulgaris

Acne vulgaris: Origins, symptoms and current treatments

Acne

Acne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/Acné-généralité-image-à-la-une-_-EN.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-29 09:31:592019-11-12 14:28:03Acne vulgaris: Origins, symptoms and current treatments

Acne vulgaris: physiopathology and cell mechanisms

Acne, Sebaceous gland regulation

Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes).
QIMA Life Sciences has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-29 09:30:252019-09-13 07:40:20Acne vulgaris: physiopathology and cell mechanisms

Physiology and functions of the sebaceous gland

Acne, Sebaceous gland regulation, Skin barrier and hydration

The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-28 09:24:342019-11-07 15:45:07Physiology and functions of the sebaceous gland
Adapalene and benzoyl peroxide

A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

Acne, Acné

Acne in adult women is an increasing reason for dermatological consultations.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/05/mw_Adapalene-and-benzoyl-peroxide.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-05-01 13:27:372021-08-30 13:28:10A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Acne, Cell and tissue engineering, Sebaceous gland regulation

In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662 [17] constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1…) known to be androgen-sensitive in other androgenic cells and tissues.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Acne, Cell and tissue engineering, Sebaceous gland regulation

SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2012-01-24 10:17:152019-11-13 11:28:55Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
skin inflammation

Keratinocytes as targets for cytokines in skin inflammation

Acne, Atopic dermatitis, Dermatology, Psoriasis

Current knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Keratinocytes-as-targets-for-cytokines.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-11-20 14:50:532019-05-31 09:36:35Keratinocytes as targets for cytokines in skin inflammation
5-alpha-reductase

Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis

Acne, Dermatology

We analysed the potential of a human epidermal tissue reconstituted by cell culture (RHE, provided by SkinEthic Laboratories, Nice, France) as a model for assessing 5-alphaR activity.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Expression-of-type-5alpha-reductase.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2000-12-10 13:36:372018-10-24 22:15:34Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis

 

 

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Address

QIMA Life Sciences
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1bis rue des plantes - CS 50011
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Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
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Latest posts

  • Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts
  • Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers
  • Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
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  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

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  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

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    Consultez le site cnil.fr pour plus d’informations sur vos droits.

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