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WOUND HEALING

Facilitating skin healing, minimizing the aesthetic impact on the patient and restoring optimal tissue function remain wound healing management concerns for the dermatological and cosmetic industry.
Wound healing is a complex and multi-step process based on the dialogue between numerous cellular actors.

A good knowledge and understanding of the cellular and molecular mechanisms of the healing process participating in skin regeneration are fundamental for the development of wound care therapies (APIs, biosimilars, formulations, medical devices).  QIMA Life Sciences can provide you with more than 20 years of experience in skin biology and in vitro testing. Here are some of the approaches we offer in the field of wound healing and skin regeneration for the evaluation of wound healing products.

Wound healing and skin regeneration: in vitro models and assays

QIMA Life Sciences has many in vitro or ex vivo models at your disposal:

  • Cell lines
  • Peripheral blood immune cells (PBMCs and purifed blood cell populations: subpopulations of T lymphocytes, monocytes, polymorphonuclear cells, etc.)
  • Macrophages and monocyte-derived dendritic cells
  • Normal human epidermal keratinocytes (NHEK)
  • Normal human dermal fibroblasts (NHDF)
  • Myofibroblasts
  • Mesenchymal stem cells
  • Microvascular endothelial cells
  • Normal human epidermal melanocytes (NHEM)
  • Sensory neurons
  • Reconstructed human epidermis (RHE)
  • Dermal equivalents
  • Skin explants (ex vivo)

on which we can evaluate the pro-healing effect of active compounds, formulations or medical devices by measuring:

  • Inflammatory response, cleaning of skin wounds and innate immunity
  • Reepithelialization
  • Neovascularization and neuritogenesis
  • Extracellular matrix synthesis, fibrosis and myofibroblast interaction
  • Dermal remodeling and epidermal differentiation
  • Pigmentation
Labeling of normal human epidermal keratinocytes (Collagen IV in green, tubulin in red, nuclei in blue)

Among all the standard assays proposed by QIMA Life Sciences in the field of wound healing and skin regeneration, here are a few examples:

  • Pseudotube-formation#Ctrl

    HMVEC + NHDF, differentiation/pseudotube formation (basal, pro-angiogenic agents)

    1.00€
    Add to cart Show Details
  • IL-8 release

    NHDF, IL-8 release (IL-1 alpha stimulation)

    1.00€
    Add to cart Show Details
  • Dexamethasone

    NHDF, myofibroblast transformation (TGF- beta stimulation)

    1.00€
    Add to cart Show Details
  • Procollagen I synthesis

    NHDF, procollagen I synthesis/release (basal)

    1.00€
    Add to cart Show Details
  • Cell proliferation

    NHDF, proliferation (basal)

    1.00€
    Add to cart Show Details
  • Calcium-induced gene expression

    NHEK, differentiation markers (low calcium/low cell density) (basal)

    1.00€
    Add to cart Show Details
  • Cell migration

    NHEK, migration/proliferation (basal)

    1.00€
    Add to cart Show Details
  • IL-6-release

    PBMC, LPS-stimulated monocytes, cytokine release (LPS stimulation)

    1.00€
    Add to cart Show Details
  • Etiquette

    PMN, migration (basal)

    1.00€
    Add to cart Show Details
  • NGF-stimulated

    Sensory neurons, neurite outgrowth (basal)

    1.00€
    Add to cart Show Details
PreviousNext
12
Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

Wound healing and skin regeneration: posts and publications

granulation wound healing

Wound healing, granulation phase and maturation phase

Wound healing

The third phase of wound healing, consisting in the replacement of the provisional  fibrin matrix with granulation tissue once the wound has been debrided, includes several sub-phases: re-epithelialization, fibroplasia, collagen deposition and angiogenesis.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/11/mw_SMA.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-12 15:36:082019-09-13 22:08:09Wound healing, granulation phase and maturation phase

Wound healing, hemostasis phase and inflammatory phase

Wound healing

The inflammatory phase is characterized by the sequential infiltration of polymorphonuclear neutrophils (PMNs), monocytes/macrophages and lymphocytes. IL-8 facilitates PMNs migration from surrounding blood vessels.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/11/mw_blood-cells-cicatrisation-inflammation-AdobeStock_117910248.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-10 15:40:392019-09-13 22:14:03Wound healing, hemostasis phase and inflammatory phase

Wound healing, overview

Wound healing

Wound healing is a complex and dynamic process of restoring skin cellular structures and tissue layers that involves multiple components: differentiated cells , stem cells , hair follicles, extracellular matrix (ECM) proteins, cytokines networks, microRNAs , blood vessels, nerves and mechanical forces.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/pf_Cicatrisation-Adobe.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-11-09 15:45:552019-09-13 22:25:57Wound healing, overview

Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children

Wound healing

Our studies highlight the potential of foreskin tissue for autograft applications in boys. A suitable alternative donor site for autologous cell transplantation in female paediatric burn patients remains an open question in our department. We tested the hypothesis that in vitro studies and RHE reconstructive capacities of cells from different body sites can be helpful to select an optimal site for keratinocyte isolation before considering graft protocols for girls.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_study-of-proliferation-and-3D-epidermal-reconstruction-from-foreskin.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2014-09-16 16:18:492018-10-24 21:59:38Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children

Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective

Wound healing

In the contexte of skin graft, cell suspensions transplanted directly to the wound is an attractive process, removing the need for attachment to a membrane before transfer and avoiding one potential source of inefficiency. Choosing an optimal donor site containing cells with high proliferative capacity is essential for graft success in burns.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_epidermal-healing-in-burns.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2014-09-07 16:13:052018-10-24 21:59:50Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective

Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts

Wound healing

We report a successful method for grafting paediatric males presenting large severe burns through direct spreading of autologous foreskin keratinocytes. This alternative method is easy to implement, improves the quality of skin and minimizes associated donor site morbidity. in vitro studies have highlighted the potential of foreskin tissue for graft applications and could help in tissue selection with the prospect of grafting burns for girls.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_foreskin-isolated-keratinocytes-provide.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2013-03-14 16:32:272018-10-24 22:01:55Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts

Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns

Wound healing

Keratinocytes from foreskin have a high capacity for division. A potential source of cells to provide coverage in paediatric burns.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Foreskin-in-children.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2010-12-10 15:11:492018-10-24 22:04:20Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

Cell and tissue engineering, Dermatology, Pharmacology, Wound healing

To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells’ capability of constructing a pluristratified epidermis.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Human-embryonic-stem-cell-derivatives.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2009-11-21 15:43:332019-11-13 11:29:58Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
burns

Cultured keratinocyte cells from foreskin and future application for burns in children

Wound healing

The keratinocytes resulting from foreskin have a high capacity of division. These cells can divide a long time before differentiation. The observations enable us to propose with our patients the keratinocytes from foreskin for wound healing especially for burns in children.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Cultured-keratinocyte-cells-from-foreskin.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2009-02-04 13:56:522018-10-24 22:05:32Cultured keratinocyte cells from foreskin and future application for burns in children
lipidocolloid dressing

Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing

Wound healing

The effect of Urgotul on normal human dermal fibroblast proliferation was studied in vitro and compared with that of two other dressing: Mepitel and Tulle Gras.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Lipidocolloid-dressing.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2005-05-15 10:59:162018-10-24 22:14:08Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing

 

 

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    N.B : Les catégories de données suivantes ; NOM / SOCIETE / EMAIL et PAR QUEL TYPE DE SERVICE ÊTES VOUS INTERESSE sont obligatoires. La non-fourniture de ces informations entrainera l’impossibilité pour QIMA Life Sciences de vous répondre.

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Address

QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
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Germany - Münster
USA - Buffalo, NY
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Latest posts

  • Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts
  • Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers
  • Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
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Ressources documentaires


  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

  • La base légale du traitement est l’intérêt légitime du QIMA Life Sciences. Les données collectées seront communiquées aux seuls destinataires suivants : Les services concernés et habilités par QIMA Life Sciences. Les données sont conservées pendant une durée de 3 ans à compter de la collecte ou de votre dernier contact entrant.

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  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

  • La base légale du traitement est l’intérêt légitime du QIMA Life Sciences. Les données collectées seront communiquées aux seuls destinataires suivants : Les services concernés et habilités par QIMA Life Sciences. Les données sont conservées pendant une durée de 3 ans à compter de la collecte ou de votre dernier contact entrant.

    Vous pouvez accéder aux données vous concernant, les rectifier, demander leur effacement ou exercer votre droit à la limitation du traitement de vos données, retirer votre consentement au traitement de vos données à tout moment, vous opposer au traitement de vos données et vous disposez d’un droit à la portabilité de vos données.

    Consultez le site cnil.fr pour plus d’informations sur vos droits.

    Pour exercer ces droits vous pouvez nous contacter à l’aide du lien suivant Gestion des droits ou en écrivant à dpo-qima@agencergpd.eu.

    Si vous estimez, après nous avoir contactés, que vos droits « Informatique et Libertés » ne sont pas respectés, vous pouvez adresser une réclamation à la CNIL.

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