Fibroblasts are potentially the key sensors of epidermis lesion through keratinocyte IL-1 signalling
Cicatrisation, DermatologieOur aim was to revisit the primary sterile epidermis lesion considering the alarmins constitutively expressed in the skin tissue and notably the IL-1 family members (IL-1fm) released by lesional keratinocytes.
At homeostasis, the non-lesional epidermis constitutes a barrier against various external aggressions...