Neurobiology

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Research areas

  • CNS Inflammation
  • Peripheral inflammation, sensitivity, pain, itching
  • Neurodegenerative diseases
  • Amyotrophic Lateral Sclerosis
  • Ischemia and stroke
  • Epilepsy
  • Peripheral neuropathies
  • Parkinson’s disease
  • Alzheimer’s disease
  • Demyelinating diseases and multple sclerosis
  • Neuromuscular diseases
  • Atopic dermatitis
  • Psoriasis

in vitro models for neurobiology

SNC, neuronal primary cultures (rat) :

  • cortical neurons
  • dopaminergic neurons
  • hippocampal neurons
  • mesencephalic neurons

SNC, glial primary cultures (rat) :

  • astrocytes
  • oligodendrocytes and oligodendrocyte precursor cells
  • brain microglia cells

SNP, neuronal primary cells (rat) :

  • sensory neurons
  • motoneurones
  • dorsal root ganglia (sensory neurons)

Cocultures and mixed-cultures

  • cortical neurons and oligodendrocytes, mixed culture
  • cortical neurons and astrocytes, mixed culture
  • cortical neurons, oligodendrocytes and astrocytes, mixed culture
  • sensory neurons and schwann cells, mixed cutlure
  • epithelial cells and neuronal cells, coculture
  • glial cells and neuronal cells, coculture
  • mesenchymial cells and neuronal cells, coculture

Cells lines:

  • PC12
  • SH-SY5Y
  • SK-N-SH
  • NGP

Ex vivo models:

  • human hair explant
  • human skin explant
  • completely humanized human skin-re-innervation model

Neurobiology, in vitro pharmacology assays

  • Maturation and differentiation of neural progenitor cell
  • Expression of neuromediators and corresponding receptors
  • Release of neuromediators
  • Expression of neuromodulation-specific channels and proteins associated with mechanotransduction, and neuromediator production and release from nerve fibers
  • Expression of markers associated with cutaneous nerve fiber subtypes (myelinated, unmyelinated, peptidergic, non-peptidergic)
  • Regulation of skin and hair follicle physiology

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