Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs

J. Kondratjeva1  – J. Brun1 – N. Amalric2 – F. Moog1 – D. Combarros1;3 – C. Pressanti1 – C. Zemirline4 – N. Maubert4 – M. Gatellet4 – M.C. Cadiergues1;3

1Small Animal Clinic, Université de Toulouse, ENVT, Toulouse, France – 2Synelvia, Labège, France – 3UDEAR, Université de Toulouse, INSERM, ENVT, Toulouse, France – 4Ceva Santé Animale, France


Performance of the DOUXO® S3 SEB shampoo and subsequent mousse applications (CEVA, France) was assessed over three weeks in 18 seborrheic dogs in a prospective, controlled study. The protocol combining shampoo and leave-on mousse applications resulted in a significant clinical improvement,  the maintenance of skin hydration, initial decrease and further restoration in hair lipids.


Seborrhea is frequent and time-consuming1
Shampoos are often effective2 but
• procedure takes time
• are often hard to realize
• a combination of different types is often necessary
Ophytrium3, a purified natural ingredient, has a high tolerance and a simultaneous threefold action on the skin barrier: it strengthens the mechanical barrier, limits the adhesion and biofilm formation and soothes the skin.
Seboliance4, a natural plant extract, has seboregulating properties.


Evaluate the protocol combining applications of one shampoo and subsequent mousses containing Ophytrium and Seboliance (DOUXO® S3 SEB, Ceva Santé Animale, Libourne, France) in seborrheic dogs on:
• tolerance
• performance: clinical score (CS), pruritus, skin surface cytology, natural moisturizing factors content (NMFs), hair surface lipids content (HL)



18 adult dogs (griffons, Bruno du Jura and Bleu de Gascogne)
• idiopathic greasy seborrhea
• same diet/environment prior and during the study
• randomly allocated in placebo (plain water – 6 dogs) or test (12 dogs) group

Study design

Study design



1. JS Yoon at al., Vet Dermatol, 2013, 24:84-89.e21-22.
2. W Rosenkrantz, Clin Tech Small Anim Pract, 2006, 21:106–16.
3. MH Chen et al., J Ethnopharmacol, 2016, 181:193–213.
4. K Barathikannan et al., BMC Complement Altern Med, 2016,16:264.
The study was funded by Ceva.

The study aimed to evaluate the tolerance, performance and effect on hair lipids and skin hydration of a protocol combining applications of one shampoo and subsequent mousses containing plant extracts (Ophytrium and Seboliance) in dogs with an undiagnosed chronic greasy keratinisation disorder.

Erythemato-ceruminous otitis externa (ECOE) is the most common type of otitis in dogs and is generally associated with bacterial and/or yeast infections.

Atopic dermatitis is a form of allergy of genetic origin accompanied by itching, during which the animal more easily develops allergies to environmental factors, usually pollen and dust mites.

Conjunctivitis in atopic dogs has already been described yet is rarely observed, and likely underdiagnosed in practice.

Performance of shampoo and subsequent mousse applications was assessed in seborrheic dogs. Shampoo and leave-on mousse applications resulted in a significant improvement…

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