Dermatology

We support the scientific advancement

of your Skin and Hair Therapeutic products

Dermatology & Immunodermatology Solutions

Translational models and assays to advance your pipeline from Discovery to Clinical Testing

Are you seeking validated or innovative assays to demonstrate the efficacy of your dermatological formulations? Need to characterize active ingredients, confirm mechanism of action, or screen for target engagement early in development?

At QIMA Life Sciences, we provide scientifically grounded, clinically relevant solutions to support the development of treatments for skin disorders, including psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic urticaria, phemphigoid diseases, etc.

From Biomarkers to Mechanism of Action

Our platforms are designed to assess many biomarkers such as:

  • Cytokine inhibition (e.g. IL-4, IL-13, IL-17, IL-23, TSLP)
  • JAK/STAT pathway modulation
  • Type I interferon signaling
  • Barrier restoration and immune cell activation

We help characterize your compounds using quantitative biomarkers, phospho-protein readouts, cellular responses, and gene expression profiling — ensuring mechanistic insight and translational value.

Whether you’re developing small molecules, biologics, biosimilars, peptides, monoclonal or bispecific antibodies, etc, our in vitro, ex vivo, and functional assays support rapid and reproducible evaluation of immunomodulatory activity and therapeutic potential.

Integrated Preclinical and Clinical Research Capabilities

QIMA Life Sciences offers a seamless continuum of research services, from early-stage discovery to clinical evaluation:

Preclinical Services:

  • In vitro & ex vivo screening of active compounds

  • In vivo efficacy models

  • Mechanism of action studies

  • Safety testing and regulatory-oriented protocols

  • Advanced co-culture systems for complex disease modeling

Clinical Services:

Our dedicated clinical unit sites enable early-phase studies, includingPhase I and Phase IIa clinical trials.

We also offer advanced clinical skin imaging analysis, powered by proprietary AI-based algorithms for automated and quantitative analysis of dermatological parameters. Our solutions also include standardized image capture systems, enabling consistent and objective data collection across study sites.

Tailored Study Design & Scientific Guidance

Our expert team works with you to:

  • Select the most relevant models based on disease context and target biology

  • Customize study design to match your regulatory and scientific goals

  • Provide regular updates, transparent reporting, and expert interpretation

A Trusted Partner in Immunodermatology Innovation

With over 20 years of experience in skin biology, immunopharmacology, and biomarker-based development, QIMA Life Sciences is your partner to de-risk and accelerate the journey from early discovery to clinical translation.

Let us help you bring your next dermatology breakthrough to life — with science at the core.

Unique Access to Human Skin & Hair Samples

We provide access to a diverse biobank of healthy and pathological skin and hair samples, collected through our network of dermatologists and surgeons. These samples are used to:

  • Isolate primary cells from diseased tissue

  • Identify targets

  • Identify and validate disease-specific biomarkers

  • Maintain functional ex vivo organ cultures for compound testing

This ensures high physiological relevance for early efficacy and safety evaluation.

Preclinical & Clinical Research in Dermatology

We can support you with:

We offer state-of-the-art techniques, e.g. (single cell) RNAseq, laser capture microdissection, applied to healthy and diseased tissue samples and pre-clinical models to identify novel targets in skin and hair disorders that can be modulated by pharmaceutical, cosmeceutical or nutraceutical compounds.

We offer state-of-the-art techniques, e.g. in situ hybridization, multiplex immunostainings, applied to healthy and diseased tissue samples and pre-clinical models to examine the source, expression and localization of your target of interest in healthy and diseased skin and hair samples.

We offer pre-clinical models, and state-of-the-art techniques, including gene silencing ex vivo, to study if modulation of your target of interest provides an efficient therapeutic benefit on skin and hair pathology within an acceptable safety window.

We offer pre-clinical models to identify the underlying molecular mechanisms in skin and hair samples addressed by your target.

We use state-of-the-art techniques and pre-clinical models, including organ culture of diseased skin samples to identify and establish biomarkers as early indicators for skin and hair disease progression.

We use pre-clinical models, including organ culture of diseased skin samples, to predict treatment responses induced by your target of interest, in skin and hair pathologies.

We offer pre-clinical models to examine the efficacy and safety of your compound on targets of interest in comparison to well known agents.

We offer pre-clinical models to test if the modulation of your target of interest efficiently affects skin and hair biology, ameliorates experimentally-induced pathological conditions or the phenotype of diseased samples.

We offer pre-clinical models to investigate the localization and distribution of your compound/drug/nutraceutical in skin and hair samples to support the selection of best mode or vehicle for administration.

We are happy to help you in customizing assays to optimally meet your research needs, and to join forces to establish clinically-meaningful models.
We are constantly working on the establishment of new assays,

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Do you have a project requiring in vitro dermatological expertise? Let’s talk about it!

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