• Flickr
  • LinkedIn
  • Youtube
LOG IN | +33 (0) 5 49 36 11 37
  • Français
  • English
  • 中文
  • Português
  • 0Shopping Cart
QIMA Life Sciences
  • Our solutions
    • in silico testing & chemoinformatics
      • in silico screening
      • Phytochemical analysis & metabolic profiling
    • in vitro and ex vivo testing
      • Catalogue
      • Cell and tissue engineering
      • Histology services
        • Slide preparation
        • Histological staining
        • Immunolabeling
        • Electron microscopy TEM/SEM
        • Slide scanning
      • Gene expression and transcriptomic analysis
        • RNA extraction and quality control
        • Rt-qPCR & PCRarrays
        • Microarrays
        • miRNA
        • In situ hybridization
        • Bioinformatics
      • Skin microbiota analysis
      • Assays on fresh whole blood
    • Preclinical Analysis
      • Analytical chemistry and bioanalysis
    • Bioanalysis & Clinical Imaging
      • Non-invasive clinical samples
      • Bioanalysis of non-invasive clinical samples
      • Clinical Imaging
  • Your Industry
    • Cosmetics
      • Hydration and skin barrier
      • Epidermal regeneration
      • Skin firmness & cohesion
      • Skin ageing
      • Skin protection & defense
      • Skin pigmentation
      • Oily skin and hyperseborrhea
      • Skin microbiota
      • Slimming and adipocyte metabolism
      • Skin microcirculation and vascularization
      • Hair growth, alopecia & canities
    • Dermatology
      • Acne
      • Alopecia, hair growth & canities
      • Wound healing and skin regeneration
      • Atopic dermatitis
      • Psoriasis
      • Skin microbiota
      • Melanoma
      • Vitiligo (coming soon)
    • Pharmacology
      • Immuno-Inflammation
      • Neurobiology
    • Veterinary medicine
  • About QIMA Life Sciences
    • Company Values
    • Who we are
    • Our commitments and responsibilities
    • Our team
    • Resources
      • Documentary resources
      • Publications
      • Webinars
  • Careers
  • Contact
  • Menu Menu

SKIN MICROCIRCULATION

& VASCULARIZATION

Skin microcirculation is located in the dermis and hypodermis layers. It plays a significant role in skin homeostasis (transportation of gases, nutrients, waste, hormones), in body thermoregulation, in blood pressure regulation and in inflammatory response.

Dermal arterioles and venules are composed of endothelial cells, connective tissues (collagen, elastin) and of smooth muscle cells which allow vessel vasoconstriction and vasodilation. Dermal capillaries are composed of a single layer of endothelial cells and of pericytes surrounded by a basal membrane.

A microcirculation dysfunction due to external factors (e.g. sun exposure, heat, cold, microorganisms and food) or internal factors (immune system) can cause redness, venous insufficiency or rosacea. Microcirculation is also altered by skin ageing, with a progressive decrease of new blood vessel formation (angiogenesis). This age-related alteration of skin microcirculation may have different consequences: sensation of cold, pallor, cutaneous ischemia, alopecia, etc.

Skin microcirculation and vascularization: in vitro models and assays

QIMA Life Sciences has many in vitro models at your disposal:

  • Human umbilical vein endothelial cells (HUVEC)
  • Human dermal microvascular endothelial cells (HMVEC-d)
  • HMVEC-d and NHDF coculture (ENDOF)
  • Human aortic smooth muscle cells (AoSMC)
  • Other skin cells (NHEK, NHDF, etc.) 

on which we can evaluate the effect of active cosmetic compounds on skin microvascularization by measuring:

  • Viability, proliferation and migration of endothelial cells
  • Cell differentiation and pseudotube (angiogenesis, neovascularization) formation
  • Protection of endothelial cells against stress (inflammation, infection, etc.)  
  • Veinotonic activity of smooth muscle cells
  • Angiogenic factor release (e.g.VEGF)

Here are a few examples among all assays proposed by QIMA Life Sciences in the field of microvascularization:

  • Calcium mobolization

    AoSMC, veinotonic activity (basal)

    1.00€
    Add to cart Show Details
  • ICAM-1 expression#Ref

    HUVEC, ICAM-1 expression (TNF- alpha stimulation)

    1.00€
    Add to cart Show Details
  • VEGF release

    NHDF, VEGF release (basal)

    1.00€
    Add to cart Show Details
  • Pseudotube-formation#Ctrl

    HMVEC + NHDF, differentiation/pseudotube formation (basal, pro-angiogenic agents)

    1.00€
    Add to cart Show Details
  • Pseudotube formation

    HMVEC + NHDF, differentiation/pseudotube formation (VEGF stimulation, anti-angiogenic agents)

    1.00€
    Add to cart Show Details
Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

 

 

NEED MORE INFORMATION?

  • This field is for validation purposes and should be left unchanged.

Address

QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
France - Labège
USA - Buffalo, NY
Brazil - Botucatu, SP

Latest posts

  • Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results
  • Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
  • Bioanalysis of non-invasive samples

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
© Copyright 2021 - QIMA LTD - Privacy policy - Configuration des Cookies
  • Flickr
  • LinkedIn
  • Youtube
Scroll to top

Forgot password ?

Lost your password? Please enter your email address. You will receive mail with link to set new password.

Retour connexion

Nous utilisons des cookies sur notre site web pour fournir l'expérience utilisateur la plus adaptée possible. Pour cela, nous enregistrons vos préférences au travers de vos différentes visites.
En cliquant sur “Tout accepter”, vous consentez à l'utilisation de l'ensemble des cookies. Si vous le souhaitez, vous pouvez visiter la "Configuration des Cookies" pour contrôler plus précisément votre consentement.
Vous pouvez également consulter notre politique concernant les cookies en cliquant ici.
Tout RejeterConfiguration des CookiesTout Accepter
Manage consent

Privacy Overview

En Français : Ce site web utilise des cookies pour améliorer votre expérience pendant que vous y naviguez. Dans ce contexte, les cookies catégorisés comme nécessaire sont stockés dans votre navigateur afin de permettre le bon comportement des fonctionnalités de base du site web. Nous utilisons également des cookies de tiers qui aident à analyser et à comprendre comment vous utilisez notre site qima-lifesciences.com. Ces cookies vont être stockés sur votre navigateur uniquement avec votre accord préalable. Vous avez la possibilité de refuser d'utiliser tout ou partie de ces cookies mais cela peut fortement détériorer votre expérience de navigation.

In English : This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use the website qima-lifesciences.com. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
CookieDurationDescription
_GA - Google Analytics2 yearsThese cookies set by Google Analytics are used for analytics purposes, including identifying each unique user and details of each page visited. For more information on Google Analytics cookies, see the Google Inc's privacy policy at http://www.google.com/policies/privacy/. You can block the use of Google Analytics cookies by downloading and installing the relevant extra component for your browser from this link: https://tools.google.com/dlpage/gaoptout
_GID - Google Analytics1 dayCe cookie est utilisé par Google Analytics à des fins d'analyses comme par exemple pour identifier chaque utilisateur unique et le détail de chaque page visitée. Pour plus d'information sur les cookies de Google Analytics, vous pouvez consulter la politique de vie privée de Google Inc à l'adresse suivante : http://www.google.com/policies/privacy/. Vous pouvez bloquer l'usage des cookies de Google Analytics en téléchargeant et en installant les composants complémentaires pour votre navigateur internet à l'adresse suivante : https://tools.google.com/dlpage/gaoptout
Advertising
Third-party profiling cookies for marketing and retargeting purposes These cookies are used by QIMA’s partners, upon your prior consent, in order to profile users for advertising and retargeting purposes. They can, for example, create user profiles to serve ads that are in line with your preferences showed as you surf the web; record your choices and activity on our website to carry out statistical analysis – for us or for third parties – by tracking your preferences and browsing behavior, serve customized ads to you, integrate some common feature of the major social media and provide it within the site, etc.
CookieDurationDescription
_gcl_au - Google Analytics4 MonthsThis cookie is used by Google AdSense for experimenting with advertisement efficiency across websites using their services. For more information on Google Analytics cookies, see the Google Inc's privacy policy at http://www.google.com/policies/privacy/. You can block the use of Google Analytics cookies by downloading and installing the relevant extra component for your browser from this link: https://tools.google.com/dlpage/gaoptout
Others
Cookie who haven't been evaluated and classified are displayed here.
Necessary
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-advertising11 MonthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Advertising".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Others".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
pll_language1 yearused by the site to identify the current user language and display page accordingly.
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
CookieDurationDescription
DV - www.google.com12 MonthsCookie used by Google Maps for saving users settings    
SAVE & ACCEPT