• Flickr
  • LinkedIn
  • Youtube
LOG IN | +33 (0) 5 49 36 11 37
  • Français
  • English
  • 中文
  • Português
  • 0Shopping Cart
QIMA Life Sciences
  • Our solutions
    • in silico testing & chemoinformatics
      • in silico screening
      • Phytochemical analysis & metabolic profiling
    • in vitro and ex vivo testing
      • Catalogue
      • Cell and tissue engineering
      • Histology services
        • Slide preparation
        • Histological staining
        • Immunolabeling
        • Electron microscopy TEM/SEM
        • Slide scanning
      • Gene expression and transcriptomic analysis
        • RNA extraction and quality control
        • Rt-qPCR & PCRarrays
        • Microarrays
        • miRNA
        • In situ hybridization
        • Bioinformatics
      • Skin microbiota analysis
      • Assays on fresh whole blood
    • Preclinical Analysis
      • Analytical chemistry and bioanalysis
    • Bioanalysis & Clinical Imaging
      • Non-invasive clinical samples
      • Bioanalysis of non-invasive clinical samples
      • Clinical Imaging
  • Your Industry
    • Cosmetics
      • Hydration and skin barrier
      • Epidermal regeneration
      • Skin firmness & cohesion
      • Skin ageing
      • Skin protection & defense
      • Skin pigmentation
      • Oily skin and hyperseborrhea
      • Skin microbiota
      • Slimming and adipocyte metabolism
      • Skin microcirculation and vascularization
      • Hair growth, alopecia & canities
    • Dermatology
      • Acne
      • Alopecia, hair growth & canities
      • Wound healing and skin regeneration
      • Atopic dermatitis
      • Psoriasis
      • Skin microbiota
      • Melanoma
      • Vitiligo (coming soon)
    • Pharmacology
      • Immuno-Inflammation
      • Neurobiology
    • Veterinary medicine
  • About QIMA Life Sciences
    • Company Values
    • Who we are
    • Our commitments and responsibilities
    • Our team
    • Resources
      • Documentary resources
      • Publications
      • Webinars
  • Careers
  • Contact
  • Menu Menu

OILY SKIN AND HYPERSEBORRHEA

Download a sample report

Oily skin is characterized by the accumulation on its surface of excess sebum, a substance secreted by sebaceous glands. Sebum is composed of triglycerides, diglycerides and monoglycerides (fatty acids linked to a glycerol motif), wax esters, squalene (very sensitive to oxidation) and sterols (eg. cholesterol). Sebum is secreted by sebocytes through a process of cell differentiation and lipid synthesis or accumulation, called lipidogenesis.

Lipidogenesis is dependent on many factors (hormones, food, pharmaceutical active ingredients, xenobiotics, etc.), which can be identified in in vitro experiments. Mature sebocytes undergo apoptosis and burst to release sebum, which travels through the hair follicle to the skin surface. Sebum lubricates the hair follicle and spreads over the surface of the skin at the stratum corneum level.

An overproduction of sebum, called hyperseborrhea, is responsible for oily skin and greasy hair. In some cases, hyperseborrhea can also contribute to the development of acne prone skin.

Oily skin and hyperseborrhea: in vitro models and assays

QIMA Life Sciences has many in vitro or ex vivo models at your disposal:

  • sebocyte cell line (SEBO662)
  • 3D sebocyte cell line (SEBO662 3D)
  • sebocyte cell line in response to androgens (SEBO662AR)

on which we can evaluate the effects of active ingredients or cosmetic formulations on sebaceous gland regulation and acne by measuring:

  • sebocyte differentiation and maturation  (EMA, KRT7, etc.)
  • lipidogenesis (lipid accumulation and production)
  • 5-alpha reductase activity and testosterone metabolism

Here are a few examples among all assays proposed by QIMA Life Sciences in the field of oily skin and hyperseborrhea:

No products found which match your selection.

Oily skin and hyperseborrhea: clinical bioanalysis

Analysis of sebum components and free fatty acids

Our company has developed ready-to-use non-invasive collection kits to analyze the surface lipids and biomarkers of the skin from your samples, or from those of your clinical center.

The sebaceous lipids and the fatty acids that constitute the epidermis and scalp are sampled using two non-invasive sampling kits (SB Kit and SW Kit).

The analysis of the components of sebum and free fatty acids makes it possible to assess:

  • The lipase activity of certain microorganisms in the skin microbiota
  • Sebum regulation
  • Inflammation – by quantification of pro / anti-inflammatory fatty acids
  • Oxidative stress – peroxidation (peroxidized squalene), detoxification (CAT, SOD)
  • Anti-microbial activity
  • The qualitative and quantitative composition of sebum

These analyses help support your claims about the efficacy of anti-acne, oily skin, soothing, protective, anti-pollution products, etc.

Sebaceous lipids screening

Detailed composition of sebum fatty acids by CG/SM

Skin microbiota and inflammation analysis

Hyperseborrhea is frequently associated with disorders of the skin microbiota. Maintaining a good balance in the microbiota helps minimize the inflammation caused by the bacteria that colonize the hair follicle (e.g. C. acnes).

Samples are taken using the SW Kit. The qualitative and quantitative analyses of the bacteria present on the surface of the skin are carried out by:

  • Traditional microbiology on agar
  • Targeted qPCR
  • Non-targeted metagenomic analysis

Inflammatory markers (cytokines, fatty acids, PGE2) are also analyzed.

These analyses help support your claims about the efficacy of “friendly” microbiota, bacteriostatic, prebiotic, soothing products, etc.

Find out about all our standard assays - Direct access to catalog
A project, an idea or a question? Contact us and let’s talk about it!

Oily skin and hyperseborrhea: posts and publications

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome

Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster1_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:542019-11-12 17:58:17Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Acne, Sebaceous gland regulation

We analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster3_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:122019-11-12 17:36:48Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation

Androgens are key regulators of sebaceous function… A link between mTOR and androgen signaling has previously been reported…as well as a link between these processes and lipid synthesis…Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.

Read more
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
lipid

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

Cosmetics, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation, Skin protection and immune defense system

Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/SEPPIC-Image-à-la-une.jpg 640 1140 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-11-29 10:57:192019-09-13 07:39:35Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

Acne vulgaris: physiopathology and cell mechanisms

Acne, Sebaceous gland regulation

Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes).
QIMA Life Sciences has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/Image-à-la-une.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-29 09:30:252019-09-13 07:40:20Acne vulgaris: physiopathology and cell mechanisms

Physiology and functions of the sebaceous gland

Acne, Sebaceous gland regulation, Skin barrier and hydration

The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/11/Sébocytes-image-à-la-une.jpg 368 701 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-11-28 09:24:342019-11-07 15:45:07Physiology and functions of the sebaceous gland

Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Acne, Cell and tissue engineering, Sebaceous gland regulation

In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662 [17] constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1…) known to be androgen-sensitive in other androgenic cells and tissues.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

Acne, Cell and tissue engineering, Sebaceous gland regulation

SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2012-01-24 10:17:152019-11-13 11:28:55Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium

 

 

NEED MORE INFORMATION?

  • This field is for validation purposes and should be left unchanged.

Address

QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
France - Labège
USA - Buffalo, NY
Brazil - Botucatu, SP

Latest posts

  • Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results
  • Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
  • Bioanalysis of non-invasive samples

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
© Copyright 2021 - QIMA LTD - Privacy policy - Configuration des Cookies
  • Flickr
  • LinkedIn
  • Youtube
Scroll to top

Forgot password ?

Lost your password? Please enter your email address. You will receive mail with link to set new password.

Retour connexion

Nous utilisons des cookies sur notre site web pour fournir l'expérience utilisateur la plus adaptée possible. Pour cela, nous enregistrons vos préférences au travers de vos différentes visites.
En cliquant sur “Tout accepter”, vous consentez à l'utilisation de l'ensemble des cookies. Si vous le souhaitez, vous pouvez visiter la "Configuration des Cookies" pour contrôler plus précisément votre consentement.
Vous pouvez également consulter notre politique concernant les cookies en cliquant ici.
Tout RejeterConfiguration des CookiesTout Accepter
Manage consent

Privacy Overview

En Français : Ce site web utilise des cookies pour améliorer votre expérience pendant que vous y naviguez. Dans ce contexte, les cookies catégorisés comme nécessaire sont stockés dans votre navigateur afin de permettre le bon comportement des fonctionnalités de base du site web. Nous utilisons également des cookies de tiers qui aident à analyser et à comprendre comment vous utilisez notre site qima-lifesciences.com. Ces cookies vont être stockés sur votre navigateur uniquement avec votre accord préalable. Vous avez la possibilité de refuser d'utiliser tout ou partie de ces cookies mais cela peut fortement détériorer votre expérience de navigation.

In English : This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use the website qima-lifesciences.com. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
CookieDurationDescription
_GA - Google Analytics2 yearsThese cookies set by Google Analytics are used for analytics purposes, including identifying each unique user and details of each page visited. For more information on Google Analytics cookies, see the Google Inc's privacy policy at http://www.google.com/policies/privacy/. You can block the use of Google Analytics cookies by downloading and installing the relevant extra component for your browser from this link: https://tools.google.com/dlpage/gaoptout
_GID - Google Analytics1 dayCe cookie est utilisé par Google Analytics à des fins d'analyses comme par exemple pour identifier chaque utilisateur unique et le détail de chaque page visitée. Pour plus d'information sur les cookies de Google Analytics, vous pouvez consulter la politique de vie privée de Google Inc à l'adresse suivante : http://www.google.com/policies/privacy/. Vous pouvez bloquer l'usage des cookies de Google Analytics en téléchargeant et en installant les composants complémentaires pour votre navigateur internet à l'adresse suivante : https://tools.google.com/dlpage/gaoptout
Advertising
Third-party profiling cookies for marketing and retargeting purposes These cookies are used by QIMA’s partners, upon your prior consent, in order to profile users for advertising and retargeting purposes. They can, for example, create user profiles to serve ads that are in line with your preferences showed as you surf the web; record your choices and activity on our website to carry out statistical analysis – for us or for third parties – by tracking your preferences and browsing behavior, serve customized ads to you, integrate some common feature of the major social media and provide it within the site, etc.
CookieDurationDescription
_gcl_au - Google Analytics4 MonthsThis cookie is used by Google AdSense for experimenting with advertisement efficiency across websites using their services. For more information on Google Analytics cookies, see the Google Inc's privacy policy at http://www.google.com/policies/privacy/. You can block the use of Google Analytics cookies by downloading and installing the relevant extra component for your browser from this link: https://tools.google.com/dlpage/gaoptout
Others
Cookie who haven't been evaluated and classified are displayed here.
Necessary
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-advertising11 MonthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Advertising".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Others".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
pll_language1 yearused by the site to identify the current user language and display page accordingly.
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
CookieDurationDescription
DV - www.google.com12 MonthsCookie used by Google Maps for saving users settings    
SAVE & ACCEPT