lipid

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

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Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.
Various forms of acne vulgaris

Acne vulgaris: Origins, symptoms and current treatments

Acne vulgaris is a chronic inflammatory disease of the skin which affects most adolescents and is the cause of over half of all dermatology consultations. This pathology, which is characterized by a hypersecretion of sebum, can be the cause of physical complications and may also lead to psychological distress.

Acne vulgaris: physiopathology and cell mechanisms

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Acne Vulgaris is a chronic inflammatory pathology located in the region of the pilosebaceous follicle. It occurs following a high production of sebum linked to hormonal (androgynous) or environmental (pollution) malfunctioning and to the colonization of the pilosebaceous follicle by certain bacteria (P. acnes). QIMA Life Sciences has developed a panel of innovative assays to discover and evaluate compounds for the treatment of acne.

Physiology and functions of the sebaceous gland

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The sebaceous gland is an organ located in the dermis. Its role is to synthesise and secrete sebum which is a component of the hydrolipidic film. The purpose of sebum is to protect the skin from external aggression and dehydration. Sebum also maintains the suppleness of the skin and hair.

Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.

Development of a new model of reconstituted mouse epidermis and characterization of its response to proinflammatory cytokines

The development of three-dimensional models of reconstituted mouse epidermis (RME) has been hampered by the difficulty to maintain murine primary keratinocyte cultures and to achieve a complete epidermal stratification. In this study, a new protocol is proposed for the rapid and convenient generation of RME,

RNA extraction and quality control

The good quality of RNA samples relies on the good conditions in which the extraction is performed. This quality will guarantee the later success of your experiments.

Hair: Follicle, Associated Structures and Growth

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Hair follicles are skin adnexa which are able to regenerate in a complete, autonomous, cyclic and asynchronous manner. The histological analysis of the pilosebaceous unit reveals a three-element organization: the epithelial compartment, the mesenchymal compartment and the sebaceous gland.
Hybridation in situ

in situ hybridization of nucleic acids

in situ hybridization is a technique for visualizing DNA or specific RNA in cells or in a portion of tissue. Its principle is based on the use of specific probes combined with the use of a marker, which may be fluorescent. The probe that is used represents a sequence of nucleic acid specifically bound to the target by complementary base pairing.
Adapalene and benzoyl peroxide

A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

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Acne in adult women is an increasing reason for dermatological consultations.
Skin care complex

A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study

In addition to the natural process of skin aging, the skin of women is significantly impacted during and after menopause.

New biological effects of Aphloïol

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In the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
skin photoaging irradiations

in vitro modeling of skin photoaging: development of evaluation tools for cosmetics

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Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.

Methods of analysis of miRNA expression

QIMA Life Sciences offers different solutions for microRNA analysis. The analysis of the whole microRNA expression profile from a DNA/microarray will detect molecular signatures and will identify microRNAs of interest for diagnosis, prognosis or potential targets for therapy.
ageing reconstructed epidermis

Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds

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The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
granulation wound healing

Wound healing, granulation phase and maturation phase

The third phase of wound healing, consisting in the replacement of the provisional  fibrin matrix with granulation tissue once the wound has been debrided, includes several sub-phases: re-epithelialization, fibroplasia, collagen deposition and angiogenesis.

Wound healing, hemostasis phase and inflammatory phase

The inflammatory phase is characterized by the sequential infiltration of polymorphonuclear neutrophils (PMNs), monocytes/macrophages and lymphocytes. IL-8 facilitates PMNs migration from surrounding blood vessels.

Wound healing, overview

Wound healing is a complex and dynamic process of restoring skin cellular structures and tissue layers that involves multiple components: differentiated cells , stem cells , hair follicles, extracellular matrix (ECM) proteins, cytokines networks, microRNAs , blood vessels, nerves and mechanical forces.

Biosimilars

The term “biosimilar” emerged in the 1980s and describes a biological product identical in all respects (dosage form, active ingredient, chemical and biological characteristics) to an original, already marketed, biological drug (vaccine, antibody, growth factor, etc.) that is no longer under patent protection. La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques
autophagy

Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast

Cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.