https://qima-lifesciences.com/wp-content/uploads/2017/03/Silab-Fig-2-2017-03-21.jpg 242 635 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-03-21 18:10:582019-09-13 21:45:10in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.
https://qima-lifesciences.com/wp-content/uploads/2016/12/Epiderme-reconstruit-passage-2-figure-1A-1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-12-21 16:21:562019-09-13 21:40:06Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Effect-of-C-xyloside.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2011-03-24 10:58:512019-11-13 11:34:13Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
These data suggest that topical C-xyloside application in vivo may be efficient in inducing a better dermal-epidermal cohesion when such a junction is deficient, as is the case in photo-aged or chronologically aged skin. Moreover, a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Tensin1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-06-04 16:13:102019-11-13 11:34:03Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
tensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing