Analytical and bioanalytical services

Analytical and bioanalytical chemistry

With our expertise in analytical & bioanalytical chemistry, we can assist you in the implementation of routine assays and in the development of new and robust analytical methods in various matrices (galenic formulation or biological samples).

The technologies of interest are mainly chromatographic methods:

LC/UV/Fluo/CAD (analytical autosampler with fraction collector)
LC/MS and LC/MSMS with ESI/APCI
GC/MS (EI, CI with CTC injector an SHS, DHS and TDU)

Matrices

Natural extracts, active ingredients
Galenic formulations
Preclinical and clinical biological samples:
- Cells / supernatants
- Reconstructed tissues / explants / biopsies
- Plasma / serum / bile / urine
- Soft tissues (liver, brain, muscles, etc.)
- Faeces & stools
- Sweat
- Sebum / surface skin lipids
- Dander (hair, nails)
- Specific non-invasive samplings

Routine assays

Cholesterol and free fatty acids (saturated and unsaturated)
Neutral lipids (squalene, waxes, mono/di/triglycerides, cholesterol & esters)
Ceramides
Eicosanoids
Lipid peroxydes
Malondialdehyde (MDA)
Natural moisturizing factor (NMF) components (serine, urocanic ac. (UCA) and pyrrolidone carboxylic ac. (PCA))
Amino acids
Vitamins
Urea and lactate
Mineral elements (calcium, potassium, argen, selenium, zinc, magnesium)
Heavy metals

Customized services

Analytical and bioanalytical method development
Validation, transfer of analytical methods to ICH guidelines for active ingredients (herbal drugs) and galenic forms (solids, semi-solids and liquids)
Analytical support for galenic development
Stability studies (stability indicating methods)
Suppliers selection/accreditation for raw materials
Establishment of Monographs for NCEs

Validation of the analytical methods is carried out in accordance with the objective of the study: validation of key parameters for POC to full validation for clinical studies. Depending on the intended use of the biomarker, we can determine the level of validation required (full GLP validation or specific requirements).

In addition to biomarkers analysis (pharmacodynamics studies), active ingredients or metabolites can be analyzed in biological matrices for early pharmacokinetics (PK), or PK/PD relations evaluation.

A project, an idea or a question? Let’s talk about it. Contact us.

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