Dermatology Drug Discovery and Development – From Target Identification to Clinical Trials
July 11, 2024 – Presented by Jean-Michel Delaval (Newtone Technologies), Dr. Marta Bertolini (Monasterium Laboratory) & Séverine de Ménonville (QIMA Life Sciences)
Explore 9 different case studies spanning all stages of the drug discovery and development process, involving several different skin conditions and diseases
- Target Identification (Ex. on Human hair follicle diseases)
- Target Characterization (Ex. on Psoriasis & Hidradenitis suppurativa)
- Target Validation (Ex. on Atopic dermatitis)
- Lead Identification (Ex. on Melanoma)
- Lead Optimization (Ex. on Psoriasis)
- Candidate Selection (Ex. on Hidradenitis suppurativa)
- In Vitro & Ex Vivo Studies (Ex. on Alopecia areata)
- In Vivo Studies (Ex. on Atopic dermatitis)
- Clinical Trials (Ex. on Vitiligo)
Boost Your Clinical Research – Analytical Methods & Skin Imaging
March 26, 2024 – Presented by Loïc Colomb (Newtone Technologies), Dr. Sabrina Höfling (Monasterium Laboratory) & Dr. Frédéric Dubor (QIMA Life Sciences)
I. Clinical Studies for the Cosmetic Industry
- Relevance and benefits
- Types of clinical studies to assess efficacy
- Limitations encountered during clinical studies
- Approaches to maximize their chances of success
II. Bioanalysis of Non-Invasive Clinical Samples
- What for & How is it performed?
- 4 most common methods to study non-invasive samples
III. Digital Imaging: Capture & Analysis
- Images can reveal different types of information
- Overview of our acquisition devices
- Grading solutions
- Digital imaging analysis
- Smart visualization of your results
IV. Taking Your Research to the Next Level: Insights From 3 Examples
- Skin barrier & hydration
- Acne
- Sensitive skin
- Case study
V. Analysis of Invasive Clinical Samples
- RNA analysis (RNAseq, scRNAseq, in situ hybridization)
- Protein analysis (complex immunostaining, cytokine array)
Oily Skin & Acne – Models and Assays for Research & Efficacy Testing
January 18, 2024 – Presented by Dr. Alix Danoy (Newtone Technologies), Dr. Anasua Pal (Monasterium Laboratory) & Dr. Samuel Guénin (QIMA Life Sciences)
I. Basics of Acne
- Epidemiology
- Physiopathology
- Types of lesions
- Clinical forms
- Relationship between oily skin and acne
II. Role of the Pharma and Dermocosmetics industries in the management of acne
III. What models and tests exist to study acne?
- 2D in vitro
- 3D in vitro
- 3D ex vivo
- Analysis of clinical samples
IV. Other factors contributing to acne development
- Nutritional factors
- Environmental factors
- Mental factors
V. How can clinical imaging bring value to acne clinical investigation?
- Local lesion approach
- Holistic approach
Skin Aging – Models and Assays for Anti-aging Research & Efficacy Testing
October 26, 2023 – Presented by Solène Trevisan (Newtone Technologies), Dr. Janin Edelkamp (Monasterium Laboratory) & Dr. Mara Carloni (QIMA Life Sciences)
I. What is skin aging?
II. What are the factors that determine skin aging?
- Intrinsic factors
- Extrinsic factors
- Environmental factors
III. What are the different levels at which we can study skin aging?
- Clinical level
- Tissular level
- Cellular level
- Molecular level
IV. What models and tests exist to study skin aging?
Hair Biology – Models for Hair Follicle Research and Testing
June 27, 2023 – Presented by Dr. Marta Bertolini (Monasterium Laboratory)
I. Introduction to the Human Hair Follicle
II. in vitro, ex vivo & in vivo models
III. Hair Health & Aging
IV. Hair Follicle Disorders
V. Clinical signs/Clinical imaging
Immunodermatology – Models for Atopic Dermatitis Research and Efficacy Testing
March 21, 2023 – Presented by Anasua Pal (Monasterium Laboratory) & Samuel Guenin (QIMA Life Sciences)
I. Epidemiology of Atopic Dermatitis
II. Physiopathology and clinical signs of Atopic Dermatitis
II. in vitro, ex vivo and in vivo models available
IV. Mimicking S. aureus infection
V. Immune and non-immune cells activation
VI. Mimicking AD like response in 3D models and healthy skin ex vivo
VII. Identification of Biomarkers, prediction of response in diseased skin explants from AD patients
VIII. Mimicking itch-related pathways
IX. Evaluate clinical signs with non-invasive clinical sampling and clinical imaging.
Solutions for early drug discovery and development in the field of Immunology
July 5th, 2022 – Presented by Emilie Schol & Vanessa Agnolutto
I. More than 20 in vitro assays available to study the effects of drugs at each stage of the innate and adaptive immune responses (phagocytosis, cell migration, cell polarization, cell activation)
II. Immune cells models available (PMNs, T cells, B cells, macrophages, dendritic cells, etc)
III. Test principles, key concepts, applications and examples of results
Newtone’s Digital Clinical Imaging for innovative product performance assessment
March 8th, 2022 – Presented by Elodie PRESTAT MARQUIS & Ghislain FRANCOIS
I. Bring value with unique systems and high quality imaging
II. Support clinical teams for high quality imaging
III. Smart algorithms for high quality image analysis
IV. Provide impactful illustrations for WOW effect valorisation
Skin inflammation & innate immunity
Models & assays to evaluate the effects of ingredients on the main actors of the skin inflammation & skin immunity.
November 16th, 2021 – Presented by Emilie Schol & Jérôme Dellacasagrande
I. Study of inflammation from in silico virtual screening to clinical samples bioanalysis.
II. Models to evaluate ingredients and finished product’s efficacy & safety (focus on the use of fresh whole blood & isolated immune cells)
Cell and tissue engineering (3D reconstructed models) for cosmetics and dermocosmetics applications
June 1, 2021 – Presented by Vanessa Agnolutto & Frederic Dubor
I. Innovations in 3D reconstructed models
II. QIMA Life Sciences’ cell bank
III. Examples of healthy reconstructed models
IV. Examples of reconstructed tissues in stress conditions:
- Exposomic (UV, pollution)
- Bacterial infection
- Models of atopic reconstructed tissues (AD, psoriasis)
- Wound healing models / physical alteration
- Preview of a study conducted on explants to mimic the effects of mask wearing on the skin, in the context of Covid-19 pandemic
Skin microbiota and dysbiosis consequences
February 2, 2021 – Presented by Simone de Faria Maraschin & Frederic Dubor
I. Reminder of the barrier functions of the skin
II. General information on skin microbiota
III. Our in vitro and non-invasive clinical samples solutions for the evaluation of the microbiota and its consequences
IV. Examples of case studies:
- Skin microbiota and skin homeostasis
- Focus on the bad smell
- Skin microbiota, oily skin & acne
- Skin microbiota and atopic skin (psoriasis, AD)
A 360° offer in the evaluation of skin barrier and hydration
- October 12, 2020 – e-cosmetic 360° – Presented by Alain Moga & Maxance Vandevyvere
- November 24, 2020 – Presented by Simone de Faria Maraschin & Frederic Dubor
I. What is skin barrier?
II. How to evaluate skin barrier?
III. Our 360° service offer to evaluate skin barrier:
- in silico virtual screening
- in vitro analysis
- Analysis of non-invasive clinical samples
IV. Examples of application of our 360° offer:
- Analysis of Filaggrin expression and of the production of natural moisturizing factors
- Analysis of the synthesis of epidermal and sebaceous lipids
V. Other factors involved in skin barrier function
Bioanalysis of non-invasive clinical samples
June 23, 25 & 30, 2020 – Presented by Alain Moga, Maxance Vandevyvere, Frederic Dubor & Simone de Faria Maraschin
I. Non-invasive sampling methods
- Presentation of the different sampling methods
- Supply chain management and training in the use of techniques
II. Examples of analysis:
- Sebum and epidermal lipids
- Natural moisturizing factors
- Skin microbiota
- Inflammation markers
- Oxidative stress markers
- Odorous molecules (volatile organic compounds)
in silico virtual screening
December 5, 2019 – Presented by Quoc Tuan Do & Samuel Guenin
I. Presentation of Selnergy
- What is Selnergy?
- Selnergy principle
- The databases used with Selnergy
- The limitations of the tool
II. Examples of applications
- Find applications of ε-viniferin
- Find new applications of meranzine
Hair pigmentation and canities
October 24, 2019 – Presented by Samuel Guenin
I. Introduction
- Hair diversity and pigmentation
- Epidemiology of canities
- The underlying causes of canities
- Treatments
II. Biology of hair pigmentation
- Development of the pigment unit of hair follicles and melanocytes
- Hair follicle melanocytes vs epidermal melanocytes
- Regulation of melanogenesis and of hair growth cycle
III. Pathophysiology of canities
