Publications
| Year | Title | Author | Journal | Link | Keywords |
|---|---|---|---|---|---|
| 2024 | SCAWA scales: a new digital tool for wrinkles clinical grading based on AI | Juliette Rengot, Elodie Prestat-Marquis, Ingrid Aime, Jean-Robert Campos, Etienne Camel, Ghislain François | International Journal of Cosmetic Science | Read the full story | claim substantiation; computer modelling; generative adversarial network; skin physiology/structure; standardization; wrinkle grading |
| 2024 | Phototoxicity of the ethanolic extract of Skeletonema marinoi for the dermocosmetic improvement of acne | Jean-Baptiste Bérard, Tan-Sothea Ouk, Vincent Sol, Louise Lefoulon, Cornelia Landolt, Karine Grenier, Naima Saad, Elise Robert, Manoëlla Sibat, Nathalie Schreiber, Samuel Guenin, Laurent Picot | Marine Drugs | Read the full story | Acne, biofilm, Cutibacterium, dermocosmetics, infection, microalgae, pheophorbide a, photodynamic therapy, pigment, Skeletonema, Staphylococcus |
| 2024 | Image Analysis of Xerosis and Atopic Dermatitis Following Prebiotic Skincare Regimen in Ethnically Diverse Patients | Hawasatu Dumbuya, Zoe Diana Draelos, Eva Cassar, Charlotte Peucat, Caroline Le Floc’hc, Katharine Podimatis | Journal of Drugs in Dermatology (JDD) | Read the full story | Atopic Dermatitis, Skin of Color, Skin texture image analysis, SkinCam |
| 2024 | Characterization of Skin Interfollicular Stem Cells and Early Transit Amplifying Cells during the Transition from Infants to Young Children | Marika Quadri, Caroline Baudouin, Roberta Lotti, Elisabetta Palazzo, Letizia Campanini, François-Xavier Bernard, Gaëlle Bellemere, Carlo Pincelli, Alessandra Marconi | International Journal of Molecular Sciences | Read the full story | Skin barrier, keratinocyte stem cells (KSC), early transit amplifying (ETA) cells, neonatal skin, pediatric skin |
| 2024 | In Vitro Study of Interleukin-6 when Used at Low Dose and Ultra-Low Dose in Micro-Immunotherapy | Camille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Mathieu Riffault, Ilaria Floris | Life (Basel) | Read the full story | Micro-immunotherapy, low doses, ultra-low doses, interleukin-6, immune cells models, immune responses modulation, allergy |
| 2024 | From consistent subjective assessment of skin sensitivity severity to its accurate objective scoring | Juliette Rengot, Imke Meyer, Nathalie Chevrot, Marielle Le Maire, Marie Cherel, Elodie Prestat-Marquis, Dominik Stuhlmann | Skin Research and Technology | Read the full story | Artificial intelligence; hyperspectral imaging; index; instrumental evaluation; multi-layer perceptron; questionnaire; sensitive skin. |
| 2024 | Melatonin facts: Melatonin lacks immuno-inflammation boosting capacities at the molecular and cellular levels | Jean A. Boutin, Valérie Hamon de Almeida, Nathalie Coussay, Celine Legros, Gilles Ferry, Karine Reybier | Biochimie | Read the full story | Melatonin, Immune-inflammation, Assays, PBMC, PMN, Interleukins |
| 2024 | Revealing novel insights on how oral supplementation with collagen peptides may prevent hair loss: Lessons from the human hair follicle organ culture | Karin I Pappelbaum, Nicolina Virgilio, Lisa Epping, Bastiaan van der Steen, Francisco Jimenez, Wolfgang Funk, Janne Prawitt, Marta Bertolini | Journal of functional food | Read the full story | Collagen Peptides, Dietary Supplementation, Hair Growth, Hair Shedding, Hair Loss, Hair Follicle Stem Cells |
| 2024 | Understanding the Mode of Action of a Micro-Immunotherapy Formulation: Pre-Clinical Evidence from the Study of 2LEBV® Active Ingredient | Camille Jacques, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Ilaria Floris | Life (Basel) | Read the full story | EBV-associated diseases; Epstein–Barr virus; cytokines; immunotherapy; interleukin-2; micro-immunotherapy |
| 2024 | A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis | Julia Tietz, Tea Gunde, Stefan Warmuth, Christopher Weinert, Matthias Brock, Alexandre Simonin, Chistian Hess, Maria Johansson, Fabio Spiga, Simone Muntwiler, Belinda Wickihalder, Dana Mahler, Dania Diem, Julia Zeberer, Robin Heiz, Naomi Flückiger, Noriko Shiraishi, Yoshihide Miyake, Nobuaki Takahashi, Markus Fehrholz, Marta Bertolini, Peter Lichtlen, David Urech, Daniel Snel | JID Innovations | Read the full story | Atopic Dermatits, Cytokines, Inflammatory skin diseases, Pruritus |
| 2023 | IL-34 Exerts Anti-Inflammatory Activities on Keratinocytes and Is Downregulated in Psoriatic-Inflamed Skin | Croquette M, Faugeroux A, Fonlupt C, Godet J, Frouin É, Garcia M, Bernard FX, Cordier-Dirikoc S, Pedretti N, Larid G, Favot L, Roblot P, Boutin D, Hainaut-Wierzbicka E, Heymann D, Lecron JC, Morel F, Jégou JF. | J Invest Dermatol. | Read the full story | Keratinocyte, skin, inflammation, psoriasis, atopic dermatitis |
| 2023 | Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants | Keren A., Reich K., Bertolini M., Moga A., Riethmüller C., Ullmann Y., Paus R., Gilhar A. | Allergy. | Read the full story | IL-2; IL-4; LPS; SCID mice; perceived stress. |
| 2023 | Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier | Lemaire G., Olivero M., Rouquet V., Moga A., Pagnon A., Cenizo V., Portes P. | PLoS One | Read the full story | ceramides, essential oils, skin barrier, skin, skin explant, 3D model |
| 2023 | Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff | Jourdain R., Moga A., Magiatis P., Fontanié M., Velegreki A., Papadimou C., Rahoul V., Guéniche A., Chopra T., Gaitanis G. | Acta Dermato-Venereologica | Read the full story | Dandruff, Malassezia restricta, scalp, skin barrier, lipoperoxidation, sebuum |
| 2023 | Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts | Kondratjeva J., Brun J., Amalric N., Moog F., Combarros D., Pressanti C., Zemirline C., Maubert N., Ollivier E., Gatellet M., Cadiergues Mc. | Vet. Sci. | Read the full story | Ophytrium; Seboliance; canine; mousse; seborrhea; shampoo; skin. |
| 2023 | Spatial distribution and functional impact of human scalp hair follicle microbiota | Marta B. Lousada, Janin Edelkamp, Tim Lachnit, Markus Fehrholz, Irena Pastar, Francisco Jimenez, Hanieh Erdmann, Thomas C. G. Bosch, Ralf Paus | JID | Read the full story | Hair follicle microbiome, LCM |
| 2023 | Biological effects of electrical epilation on human hair follicles and perifollicular skin ex vivo | Marta Bertolini, Jennifer Gherardini, Jéremy Chéret, Majid Alam, Mathias Sulk, Natalia V Botchkareva, Tamás Bíro, Wolfgang Funk, Frieder Grieshaber, Ralf Paus | Int J Cosmet Sci | Read the full story | Epilation, Skin organ culture, Hair Removal |
| 2023 | “Speed-aging” of human skin in serum-free organ culture ex vivo: An instructive novel assay for preclinical human skin aging research demonstrates senolytic effects of caffeine and 2,5-dimethylpyrazine | van Lessen M, Mardaryev A, Broadley D, Bertolini M, Edelkamp J, Kückelhaus M, Funk W, Bíró T, Paus R | Exp Dermatol | Read the full story | Skin Aging and Senescence, Skin organ culture, Spontaneous aging in serum-free medium |
| 2023 | Management of the human hair follicle microbiome by a synthetic odorant | Edelkamp J, Bispo Lousada M, Pinto D, Chéret J, Calabrese FM, Jiménez F, Erdmann H, Wessel J, Phillip B, De Angelis M, Rinaldi F, Bertolini M, Paus R | JDS | Read the full story | Microbiome, Cosmetics, Hair follicle disorders, Antimicrobial peptides |
| 2023 | Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis | Piccini I, Chéret J, Tsutsumi M, Sakaguchi S; Ponce L, Almeida, L, Funk W, Kückelhaus M; Kajiya K, Paus R, Bertolini M | Exp Dermatol | Read the full story | Merkel cell, Chemosensation, Olfactory receptor, Vesicle release |
| 2023 | mTORC1 activity negatively regulates human hair follicle growth and pigmentation | Suzuki T, Chéret J, Dinelli Scala F, Akhundlu A, Gherardini J, Demetrius D, O'Sullivan JDB, Kuka Epstein G, Bauman AJ, Demetriades C, Paus R | EMBO Reports | Read the full story | Canities, Hair follicle pigmentation, Hair follicle organ culture, Melanogenesis, mTORC1 signaling |
| 2023 | Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease | Cole S, Manghera A, Burns L, Barrett J, Yager N, Rhys H, Skelton A, Cole J, Goodyear CS, Griffiths M, Baeten M, Bertolini M, Shaw S, Al-Mossawi H, Maroof A | Journal of Allergy and Clinical Immunology | Read the full story | Psoriasis, IL-17 signaling, STAT signaling, lesional skin organ culture, scRNAseq |
| 2023 | Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile | Lousada MB, Edelkamp J, Lachnit T, Fehrholz M, Jimenez F, Paus R | BMC Research Notes | Read the full story | Hair follicle organ culture, Microbiome, Laser-Capture Microdissection |
| 2023 | Involvement of ILC1-like innate lymphocytes in human autoimmunity: lessons from alopecia areata | Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A | eLife | Read the full story | Alopecia Areata, Hair Loss, Hair growth, Humanized mouse model, innate lymphoid cells-type 1 |
| 2023 | Application of topical Sandalore® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivo | Edelkamp J, Lousada MB, Pinto D, Chéret J, O'Sullivan JDB, Biundo A, Jimenez F, Funk W, Roessing C, Rippmann V, Paus R, Bertolini M | Skin Pharmacol. Physiol. | Read the full story | Skin organ culture, Chemosensation, Olfactory Receptors, Microbiome, Antimicrobial peptides |
| 2023 | Concentration-dependent stimulation of melanin production as well as melanocyte and keratinocyte proliferation by melatonin in human eyelid epidermis | Sevilla A, Chéret J, Lee W, Paus R | Exp. Dermatol. | Read the full story | Full-thickness eyelid skin organ culture, melatonin, melanogenesis, |
| 2023 | Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants | Keren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar A | Allergy | Read the full story | Atopic Dermatitis; humanized mouse model; xenotransplants; skin barrier deficits |
| 2023 | Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff | Roland Jourdain, Alain Moga, Prokopios Magiatis, Maxime Fontanié, Aristea Velegraki, Chrysanthi Papadimou, Valérie Rahoul, Audrey Guéniche, Tarun Chopra, George Gaitanis | Acta Derm Venereol. | Read the full story | Dandruff, Malassezia restricta, lipoperoxidation, hair, cosmetics |
| 2023 | A Dermocosmetic Significantly Reduces the Frequency and Intensity of Facial Skin Intolerability and Sensitivity in Subjects with Skin Intolerant to Skin Care Products and Sensitive Skin. | Kerob D, Czermanska A, Karamon EM, Moga A, Lecerf G, Nioré M, Le Dantec G, Le Floc'h C, Tan J. | Clin Cosmet Investig Dermatol. | Read the full story | allergic prone skin; dermocosmetic; sensitive skin. |
| 2023 | Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants | Keren A., Reich K., Bertolini M., Moga A., Riethmüller C., Ullmann Y., Paus R., Gilhar A. | Allergy. 2023;00:1–16 | Read the full story | IL-2, IL-4, LPS, perceived stress, SCID mice |
| 2023 | Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm | Quentin Marin Dit Bertoud, Clémence Bertold, Khaled Ezzedine, Amit G Pandya, Marie Cherel, Alejandro Castillo Martinez, Marie-Anne Seguy, Marwa Abdallah, Jung Min Bae, Markus Böhm, Davinder Parsad, David Rosmarin, Albert Wolkerstorfer, Philippe Bahadoran, Manon Blaise, Pierre-Michel Dugourd, Valérie Philippo, Jean-Michel Delaval, Thierry Passeron | Br J Dermatol. | Read the full story | vitiligo, artificial intelligence, clinical trial, instrumental evaluation, skin image, skin depigmentation |
| 2023 | Predictors of female age, health and attractiveness perception from skin feature analysis of digital portraits in five ethnic groups | Rainer Voegeli, Remo Campiche, Romain Biassi, Anthony V Rawlings, Todd K Shackelford, Bernhard Fink | Int J Cosmet Sci. | Read the full story | cross-cultural ethnicity, face perception, skin image analysis, women |
| 2023 | Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers | Sarah Gougeon, Elsa Hernandez, Nathalie Chevrot, Thibault Vergne, Marie Cherel, Elodie Prestat-Marquis, Matthieu Jomier, Elodie Burty-Valin | Skin Res Technol | Read the full story | 3D skin imaging, connected imaging, moisturiser, nomadic imaging, roughness, skin microrelief,skin pattern |
| 2023 | Video-based paired comparison to evaluate some cosmetic products under camera movement for dynamic performance | Emilie Yokoyama, Ghislain Francois, Margalith Harrar, Chafik Bachatene, Kumiko Udodaira, Solène Trévisan, Alexandre Nicolas, Damien Velleman, Frederic Flament | Int J Cosmet Sci. | Read the full story | cosmetic evaluation, clinical evaluation, skin imaging, skin video, 3D skin imaging |
| 2023 | Comparative analysis of original face and skin-warped average face images for the scoring of skin attributes | Quentin Marin, Tatsuya Honda, Yuri Okano, Marie Cherel, Elodie Prestat-Marquis | Skin Res Technol | Read the full story | ageing signs, average face, claim substantiation, digital image, skin grading, statistics |
| 2023 | Lip color measurement: A new hyperspectral imaging device | Héloïse Vergnaud, Marie Cherel, Ghislain Francois, Zoé Charton, Eléonore Loescher, Laurence Caisey, Germaine Gazano | Skin Res Technol | Read the full story | skin color, lips, lip color |
| 2023 | Comparative analysis of original face and skin-warped average face images for the scoring of skin attributes | Marin Q., Honda T., Okano Y., Cherel M., Prestat-Marquis E. | Skin Res Technol. 2023;29(4) | Read the full story | ageing signs, average face, claim substantiation, digital image, skin grading, statistics |
| 2023 | Exploring sensitive skin to design reliable measurements | Juliette Rengot, Dominik Stuhlmann, Imke Meyer, Nathalie Chevrot, Marielle Le Maire, Juliet Chamla, Jordan Gierschendorf, Marie Cherel, Elodie Prestat-Marquis | Skin Res Technol | Read the full story | sensitive skin, skin imaging, statistics, cosmetics, clinical evaluation, SpectraFace hhyperspectral images |
| 2022 | IL-17 and IL-22 are pivotal cytokines to delay wound healing of S. aureus and P. aeruginosa infected skin. | Lecron JC, Charreau S, Jégou JF, Salhi N, Petit-Paris I, Guignouard E, Burucoa C, Favot-Laforge L, Bodet C, Barra A, Huguier V, Mcheik J, Dumoutier L, Garnier J, Bernard FX, Ryffel B, Morel F. I | Front Immunol. | Read the full story | Th17; cytokine; inflammation; pathogen; skin; wound healing. |
| 2022 | Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes | Cordier-Dirikoc S., Pedretti N., Garnier J., Clarhaut-Charreau S., Ryffel B., Morel F., Bernard Fx., Hamon De Almeida V., Lecron Jc. And Jegou Jf. | Front. Immunol. | Read the full story | IL-1; epidermal lesion; fibroblasts; keratinocytes; skin; sterile inflammation. |
| 2022 | Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa | Moog F., Mivielle J., Brun J., Oana Dumitrache M., Amalric N., Lecru La., Pressanti C., Kondratjeva J., Combarros D., Fantini O., Cadiergues Mc. | Vet. Sci. | Read the full story | cytokines; dog; ear cleanser; ear infection; ear lipids; erythemato-ceruminous otitis. |
| 2022 | Clinical Evaluation of Indian Sandalwood Oil and Its Protective Effect on the Skin against the Detrimental Effect of Exposome | Lutchmanen Kolanthan V., Brown A., Soobramaney V., Philibert Eg., Newton V., Hosenally M., Nusayha Sokeechand B., Petkar G., Moga A., Andres P., Bibi Mandary M., Hettiarachchi D. | Cosmetics | Read the full story | oxidative stress; blue light; pollution; in vivo; Indian sandalwood oil; squalene |
| 2022 | Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange-Preliminary Results | Lecru La., Combarros D., Moog F., Marinovic L., Kondratjeva J., Amalric N., Pressanti C., Cardiergues Mc. | Animals | Read the full story | Otodectes cynotis; atopic dermatitis; biomarkers; dog; inflammation; interleukin-8; otitis. |
| 2022 | The Unitary Micro-Immunotherapy Medicine Interferon-γ (4 CH) Displays Similar Immunostimulatory and Immunomodulatory Effects than Those of Biologically Active Human Interferon-γ on Various Cell Types. | Jacques C, Chatelais M, Fekir K, Brulefert A, Floris I. | Int J Mol Sci. | Read the full story | centesimal Hahnemannian dilution; cytokines secretion; homeopathically prepared interferon-γ; immune-related markers; immunomodulation; immunostimulant; in vitro; interferon-γ; micro-immunotherapy; unitary medicine. |
| 2022 | Antiviral Effect of hBD-3 and LL-37 during Human Primary Keratinocyte Infection with West Nile Virus. | Chessa C, Bodet C, Jousselin C, Larivière A, Damour A, Garnier J, Lévêque N, Garcia M. | Viruses. | Read the full story | LL-37; West Nile virus; antimicrobial peptides; antiviral; flavivirus; hBD-3; immunomodulation; keratinocytes. |
| 2022 | Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo | Horesh EJ, Gherardini J, Alam M, Rodriguez-Feliz J, Bauman AJ, Chéret J, Paus R | JID | Read the full story | HF organ culture ex vivo; HPS-Axis; brain-HF-axis; neuroendocrinology |
| 2022 | Downregulation of pathogenic MICA-NKG2D interactions as a novel strategy in alopecia areata management: a new rationale for adjunct statin therapy? | Gherardini J, Rivas KE, Chéret J, Strbo N, Paus R | JEADV | Read the full story | Outer Root Sheath Keratinocytes; in vitro models, Alopecia Areata; IP collapse |
| 2022 | Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation | Wikramanayake TC, Nicu C, Gherardini J, Mello ACGCV, Chéret J, Paus R | JID | Read the full story | Sebaceous gland function, MPZL3 |
| 2022 | The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle | O'Sullivan JDB , Peters EMJ, Amer Y, Atuluru P, Chéret J, Rosenberg AM, Picard M, Paus R | Front Neuroendocrinol. | Read the full story | brain-HF axis; perceived stress in hair greying and hair loss, neuroendocrinology |
| 2022 | Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions | Platt CI, Cheret J, Paus R | Arch Dermatol Res. | Read the full story | Organotypic model, 3D dermal papilla spheroids, Epithelial mesenchymal interaction, hair matrix |
| 2022 | A plaidoyer for the use of human skin xenotransplant mouse models in preclinical psoriasis research | Gilhar A, Reich K, Keren A, Paus R | J Eur Acad Dermatol Venereol. | Read the full story | Psoriasis, humanized mouse model, xenotransplantation |
| 2022 | Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype | Piccini I, Sousa M, Altendorf S, Jimenez F, Rossi A, Funk W, Biró T, Paus R, Seibel J, Jakobs M, Yesilkaya T, Edelkamp J, Bertolini M | Nutrients. | Read the full story | Female pattern hair loss, hair follicle, metabolism, nutrient supplementation |
| 2022 | Circadian rhythms in psoriasis and the potential of chronotherapy in psoriasis management | Luengas-Martinez A, Paus R, Iqbal M, Bailey L, Ray DW, Young HS | Exp. Dermatol | Read the full story | VEGF-A, chronotherapy, circadian rhythms, psoriasis. |
| 2022 | Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons | Senna MM, Peterson E, Jozic I, Chéret J, Paus R | JID Innov. | Read the full story | 5α-reductase inhibitor, alopecia areata, androgenetic alopecia, corticotropin-releasing hormone, epithelial‒mesenchymal transition, frontal fibrosing alopecia, hair follicle, immune privilege, keratin, keratinocyte, lichen planopilaris, macrophage, major histocompatibility complex, primary cicatricial alopecia, personal care product, peroxisome proliferator–activated receptor-γ, stem cell, substance P, epithelial hair follicle stem cell, α-melanocyte-stimulating hormone |
| 2022 | Hydra and the hair follicle - An unconventional comparative biology approach to exploring the human holobiont | Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCG | Bioessays. | Read the full story | Antimicrobial peptides, microbial ecology, microbiome, model organisms |
| 2022 | Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging | Wikramanayake TC, Chéret J, Sevilla A, Birch-Machin M, Paus R | Expert opinion on Therapeutic Targets | Read the full story | Reactive oxygen species (ROS), alopecia, appendage, epidermis, hair follicle, mitochondria, myelin protein zero-like 3 (MPZL3), sebaceous gland, skin cancer |
| 2022 | Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective | Sevilla A, Chéret J, Slominski RM, Slominski AT, Paus R | J. Pineal res | Read the full story | Hair follicle, human skin, melanocyte, melatonin, pigmentation |
| 2022 | An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo | Campiche R, Le Riche A, Edelkamp J, Fernandez Botello A, Martin E, Gempeler M, Bertolini M | Int J Cosmet Sci. | Read the full story | Leontopodium alpinum, anagen phase, anti-hair loss, hair follicle, hair growth, versican |
| 2022 | Human organ reju-venation by VEGF-A: Lessons from the skin | Keren A, Bertolini M, Yaniv K, Ullmann Y, Paus R, Gilhar A | Sci. Advances | Read the full story | VEGF-A, skin aging, skin rejuvenation, humanized mouse model, skin organ culture ex vivo |
| 2022 | Effect of minoxidil formulations on human scalp skin xenotransplants on SCID mice: A novel pre-clinical in vivo assay for androgenetic alopecia research | Gilhar A, Keren A, Ullmann Y, Wu J, Paus R | Exp Dermatol. | Read the full story | Mouse model, xenotransplant, preclinical model, hair growth, hair loss, androgenetic alopecia |
| 2022 | Growth Hormone and the Human Hair Follicle | Horesh E.J, Chéret J, Paus R | Int J Mol Sci. | Read the full story | Growth hormone, neuroendocrine, hair follicle, hair growth |
| 2022 | Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. | Monjotin N, Tenca G. | Microvasc Res. | Read the full story | Calcium mobilization; Chronic venous disease; Cyclo 3® Fort; Edema; Lymphatic contractility; Lymphatic muscle cell; Lymphotonic; MPFF; Ruscus/HMC/Vit C. |
| 2022 | Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract. | Segarra S, Naiken T, Garnier J, Hamon V, Coussay N, Bernard FX. | Vet Sci. | Read the full story | antimicrobial peptides; canine atopic dermatitis; filaggrin; glycosaminoglycans; hyaluronic acid; sphingolipids; sphingomyelin; β-defensin. |
| 2022 | Transient and reversible reduction of stratum corneum filaggrin degradation products after allergen challenge in experimentally mite-sensitised atopic dogs | Thierry Olivry, Judy S Paps, Nicolas Amalric | Vet Dermatol. | Read the full story | Allergens, Animals, Dermatitis, Atopic / veterinary, Dog Diseases, Dogs, Epidermis, Filaggrin Proteins, Mites, Skin |
| 2022 | A comprehensive comparison of facial skin hydration based on capacitance and conductance measurements in Chinese women | Rainer Voegeli, Marie Cherel, Rotraut Schoop, Anthony V Rawlings | Int J Cosmet Sci. | Read the full story | colour mapping, facial skin hydration, moisturization, skin capacitance, skin conductance,stratum corneum |
| 2022 | 5-α reductase inhibition by Epilobioum fleischeri extract modulates facial microbiota structure | Riccardo Sfriso, Joshua Claypool, Magalie Roche, Dominik Imfeld | Int J Cosmet Sci. | Read the full story | claim substantiation, Epilobium fleischeri, microbiota, reference frames, skin care, skinmicrobiome |
| 2022 | Identifying patterns behind the changes in skin pores using 3-dimensional measurements and K-means clustering | Seongwoo Lee, Marie Cherel, Sarah Gougeon , Euitaek Jeong, Jun-Man Lim, Sun Gyoo Park | Skin Res Technol | Read the full story | 3D assessment of pores, aging, connecting phenomena of skin pores, K-means clustering, skinpores, skin surface, wrinkles |
| 2022 | Analysis of correlation and construction of a predictive model of skin transparency using parameters from digital images of the face | Quentin Marin, Tatsuya Honda, Hiroaki Nakajima, Yuri Okano, Marie Cherel, Elodie Prestat-Marquis | Skin Res Technol | Read the full story | Colorface®, predictive model, skin transparency, visual clues |
| 2022 | Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers | Gougeon S., Hernandez E., Chevrot N., Vergne T., Cherel M., Prestat-Marquis E., Jomier M., Burty-Valin E. | Skin Res Technol. 2023;29(1) | Read the full story | 3D skin imaging, connected imaging, moisturiser, nomadic imaging, roughness, skin microrelief, skin pattern, cosmetics |
| 2021 | The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages | Yue ZC, Lei MX, Paus R, Chuong CM | Biol Rev Camb Philos Soc. | Read the full story | VGEF, psoriasis, therapeutic strategies |
| 2021 | Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo | Nicu C, Jackson J, Shahmalak A, Pople J, Ansell D, Paus R | Arch Dermatol Res. | Read the full story | hair follicle, adiponectin, pigmentation, hair follicle organ culture, ex vivo, dermal papilla, WNT |
| 2021 | Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness | Hochfeld L.M, Bertolini M, Broadley D, Botchkareva N.V, Betz R.C, Schoch S, Nöthen M.M, Heilmann-Heimbach S. | PLoS One. | Read the full story | hair follicle, male pattern hair loss, WNT, genetic |
| 2021 | Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase | Figlak k, Williams G, Bertolini M, Paus R, Philpott M.P. | Sci Rep. | Read the full story | hair follicle, metabolism, outer root sheath keratinocytes, hair follicle organ culture, ex vivo |
| 2021 | Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle | Uchida Y, Gherardini J, Pappelbaum K, Chéret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R. | J Autoimmun. | Read the full story | alopecia areata, autoimmunity, resident human γδT-cells, hair follicle, MICA, NKG2D, stress, ex vivo model |
| 2021 | The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets | Suzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R. | Exp Dermatol. | Read the full story | hair growth, skin, psoriasis, hair follicle |
| 2021 | PPARγ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition | Piccini I, Brunken L, Chéret J, Ghatak S, Ramot Y, Alam M, Purba TS, Hardman J, Erdmann H, Jimenez F, Paus R, Bertolini M. | Br J Dermatol. | Read the full story | alopecia, chemotherapy, treatment, prevention, PPARγ agonist |
| 2021 | Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology. | Wikramanayake TC, Nicu C, Chéret J, Czyzyk TA, Paus R. | Bioessays. | Read the full story | Myelin Protein Zero-like 3, CLOCK, PPARγ, mitochondria |
| 2021 | A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism? | Limbu SL, Purba TS, Harries M, Wikramanayake TC, Miteva M, Bhogal RK, O'Neill CA, Paus R. | Bioessays. | Read the full story | dandruff, scalp, hair follicle, cosmeceuticals |
| 2021 | Quantitative mapping of human hair greying and reversal in relation to life stress | Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M. | Elife. | Read the full story | stress, premature greying, hair shaft proteomics |
| 2021 | A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? | Ivan Jozic, Jérémy Chéret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf Paus | Biomedicines | Read the full story | caveolin-1, scarring alopecia, hair follicle stem cells, immune privilege collapse |
| 2021 | Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo | Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R. | J Invest Dermatol. | Read the full story | skin explants, re-innervation, iPS cells |
| 2021 | Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotype | Thibault Kervarrec, Jérémy Chéret, Ralf Paus, Roland Houben, David Schrama | Exp Dermatol. | Read the full story | Merkel cells, carcinoma, polyomavirus, hair follicle, malignant transformation, tumor |
| 2021 | Can antibiotic-induced changes in the composition of the hair follicle microbiome regulate human hair growth? | Bispo Lousada M, Edelkamp J, Lachnit T, Erdmann H, Paus R | Exp Dermatol. | Read the full story | microbiome, hair growth, hair follicle |
| 2021 | UDP-GlcNAc-1-phosphotransferase is a clinically important regulator of human and mouse hair pigmentation | Tiede S, Hundt JE, Paus R | J Invest Dermatol. | Read the full story | hair follicle, pigmentation, therapeutics, greying |
| 2021 | Quantitative mapping of human hair greying and reversal in relation to life stress | Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Kumar Soni R, Lacefield C, Tobin DJ, Paus R, Picard M | Elife. | Read the full story | hair follicle, greying, pigmentation, stress |
| 2021 | Sensory re-innervation of human skin by human neural stem cell-derived peripheral neurons ex vivo | Chéret J, Piccini I, Gherardini J, Ponce L, Bertolini M, Paus R | J Invest Dermatol. | Read the full story | model, skin re-innervation, itch irritation |
| 2021 | A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? | Jozic I, Chéret J, Abujamra BA, Miteva M, Gherardini J, Paus R | Biomedicines. | Read the full story | hair follicle, alopecia target, frontal fibrosing alopecia |
| 2021 | Pathobiology questions raised by telogen effluvium and trichodynia in COVID-19 patients | Di Landro A, Naldi L, Glaser E, Paus R, Tosti A | Exp Dermatol. | Read the full story | Continuous Positive Airway Pressure, paracetamol, systemic steroids, anticoagulants, clinical manifestations |
| 2021 | Stress and Nasal Allergy: Corticotropin-Releasing Hormone Stimulates Mast Cell Degranulation and Proliferation in Human Nasal Mucosa | Yamanaka-Takaichi M, Mizukami Y, Sugawara K, Sunami K, Teranishi Y, Kira Y, Paus R, Tsuruta D | Int J Mol Sci. | Read the full story | inflammation, stem cell factor, antalarmin, therapeutics |
| 2021 | Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenance | Mardaryev A, van Lessen M, Alam M, Acosta FJ, Bíró T, Paus R | J Invest Dermatol. | Read the full story | hair cycle, hair follicle, triphenylphosphine oxide, TRPM5 |
| 2021 | Beyond the NFAT Horizon: From Cyclosporine A-Induced Adverse Skin Effects to Novel Therapeutics | Hawkshaw NJ, Paus R | Trends Pharmacol Sci. | Read the full story | hypertrichosis, human model systems, immunosuppressive therapy |
| 2021 | The biology of human hair greying | O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R | Biol Rev Camb Philos Soc. | Read the full story | melanogenesis, bulge melanocyte stem cells, pigmentation, HFPU melanocyte survival |
| 2021 | Inhibition of Shh Signaling through MAPK Activation Controls Chemotherapy-Induced Alopecia | Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z | J Invest Dermatol. | Read the full story | antimitotic, apoptosis-promoting, MAPK-Shh axis |
| 2021 | Compartmentalised metabolic programmes in human anagen hair follicles: New targets to modulate epithelial stem cell behaviour, keratinocyte proliferation and hair follicle immune status? | Purba TS, Berriche L, Paus R | Exp Dermatol. | Read the full story | Warburg effect, hair growth, immunological HF microenvironment |
| 2021 | Human epithelial stem cell survival within their niche requires "tonic" cannabinoid receptor 1-signaling - Lessons from the hair follicle | Sugawara K, Zákány N, Tiede S, Purba T, Harries M, Tsuruta D, Bíró T, Paus R | Exp Dermatol. | Read the full story | endocannabinoid system, organ-cultured human HFs, human adult epithelial stem cell |
| 2021 | Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research | Stone RC, Aviv A, Paus R | J Invest Dermatol. | Read the full story | pigmentary unit, chemotherapy-induced alopecia, telogen effluvium, androgenetic alopecia, cicatricial alopecia |
| 2021 | Dermal adipose tissue secretes HGF to promote human hair growth and pigmentation | Nicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N, Farjo B, Pople J, Bhogal R, Hardman JA, Plikus MV, Ansell DM, Paus R | J Invest Dermatol. | Read the full story | hepatocyte growth factor, human HF-dWAT co-culture, human hair growth, pigmentation |
| 2021 | Shining a (blue) light on hair follicle chronobiology and photobiomodulation | Paus R | Exp Dermatol. | Read the full story | hair follicles, metabolism, clock gene |
| 2021 | Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions | Platt CI, Chéret J, Paus R | Arch Dermatol Res. | Read the full story | microdissected scalp hair follicles, dermal papilla, 3-dimensional (3D) spheroids |
| 2021 | Translational Neuroendocrinology of Human Skin: Concepts and Perspectives | Ramot Y, Böhm M, Paus R | Trends Mol Med. | Read the full story | neurohormones, neuropeptides, neurotransmitters, human skin physiology |
| 2021 | Barrier disruption, dehydration and inflammation: Investigation of the vicious circle underlying dry skin | Cécile Bize, Erwan Le Gélébart, Alain Moga, Bruno Payré, Christine Garcia | Int J Cosmet Sci. | Read the full story | Helichrysum stoechas extract; dry skin; inflammation; inflamm’dryness; skin barrier. |
| 2021 | A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke | Dalrymple A., Mcewan M., Brandt M., Bielfeldt S., Bean Ej., Moga A., Coburn S., Hardie G. | Skin Res Technol. | Read the full story | cigarette smoke; cosmetic; electronic cigarette/e-cigarette; hygiene; skin damage; skin staining; tobacco heating product. |
| 2021 | Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study | Pressanti C., Ravailhe E., Castellote-Brun J., Amalric N., Lecru La., Kondratjeva J., Moog F., Daniel Combarros D., Douet Jy, Cadiergues Mc. | Veterinary Dermatology | Read the full story | Conjunctivitis, diagnosis, Conjunctivitis, Allergic, veterinary medecine, Cytokines, Dog Diseases / diagnosis, Dogs, Tears |
| 2021 | Anti-pollution effects of two antioxidants and a chelator—Ex vivo electron spin resonance and in vivo cigarette smoke model assessments in human skin | Bielfeldt S., Jung K., Laing S., Moga A., Wilhelm Kp. | Skin Res Technol. | Read the full story | ESR; Urban Dust; anti-pollution; antioxidants; chelators; cigarette smoke model; in vivo model; malondialdehyde; particulate matter; squalene oxidation, human skin |
| 2021 | Cross-cultural perception of female facial appearance: A multi-ethnic and multi-centre study | Rainer Voegeli, Rotraut Schoop, Elodie Prestat-Marquis, Anthony V Rawlings, Todd K Shackelford, Bernhard Fink | PloS One | Read the full story | Face, Ethnicities , African people, French people, Cross-cultural studies, Chinese people, Health informatics , Research assessment, skin imaging, skin imaging |
| 2021 | Real-time skin chromophore estimation from hyperspectral images using a neural network | Lou Gevaux, Jordan Gierschendorf, Juliette Rengot, Marie Cherel, Pierre Séroul, Alex Nkengne, Julie Robic, Alain Trémeau, Mathieu Hébert | Skin Res Technol | Read the full story | 3D skin imaging, cosmetics, artificial intelligence, neural network, hyperspectral images, clinical evaluation, non invasive |
| 2021 | Differences between perceived age and chronological age in women: A multi-ethnic and multi-centre study | Rainer Voegeli, Rotraut Schoop, Elodie Prestat-Marquis, Anthony V Rawling,, Todd K Shackelford, Bernhard Fink | Int J Cosmet Sci. | Read the full story | chronological age, cross-cultural, ethnicity, face, perceived age, perception, women |
| 2020 | Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model | Gilhar A, Laufer Britva R, Keren A, Paus R | J Investig Dermatol | Read the full story | alopecia areata, therapeutic effects, preclinical |
| 2020 | The Evolving Pathogenesis of Alopecia Areata: Major Open Questions | Paus R | J Investig Dermatol. | Read the full story | autoimmune alopecia areata, atopic dermatitis, hair follicle |
| 2020 | Mouse models of atopic dermatitis: a critical reappraisal | Gilhar A, Reich K, Keren A, Kabashima K, Steinhoff M, Paus R | Exp Dermatol. | Read the full story | atopic dermatitis, human skin xenotransplants, SCID mice |
| 2020 | Towards a renaissance of dermatoendocrinology: Selected current frontiers | Böhm M, Paus R | Exp Dermatol. | Read the full story | |
| 2020 | Re-innervation of human skin by rat dorsal root ganglia permits to study interactions between sensory nerve fibers and native human dermal mast cells ex vivo | Chéret J, Ponce L, Le Gall-Ianotto C, Bertolini M, Paus R | Exp. Dermatol. | Read the full story | human skin organ culture, functional sensory skin nerves, neurogenic skin inflammation |
| 2020 | Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling | Nicu C, Wikramanayake TC, Paus R | Exp. Dermatol. | Read the full story | intrinsic oscillator system, myelin protein zero- like 3, telogen‐to‐anagen transition |
| 2020 | Pro-inflammatory Vδ1 + T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles | Uchida Y, Gherardini J, Schulte-Mecklenbeck A, Alam M, Chéret J, Rossi A, Kanekura T, Gross CC, Arakawa A, Gilhar A, Bertolini M, Paus R | J Dermatol Sci. | Read the full story | skin-resident γδT-cells, alopecia areata, hair follicle, innate immunity |
| 2020 | The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis | Haslam IS, Paus R | Bioessays | Read the full story | human hair growth, regeneration, hair loss therapy, stem cell niches |
| 2020 | A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo | Bertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus R | Br J Dermatol. | Read the full story | Wnt signalling, hair growth, hypertrichosis, catagen development |
| 2020 | Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis? | Hardman JA, Nicu C, Tai C, Harries M, Mironov A, Purba TS, Paus R | J Dermatol. Sci. | Read the full story | autophagy, lysosomal degradation, ATG5, catagen, |
| 2020 | Exploring the human hair follicle microbiome | Lousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus R | Br. J Dermatol. | Read the full story | microbiota, human holobiont, antimicrobial peptides, microbial survival |
| 2020 | Inhibition of sonic hedgehog signaling via MAPK activation controls chemotherapy-induced alopecia | Haslam IS, Zhou G, Xie G, Teng X, Ao X, Yan Z, Smart E, Rutkowski D, Wierzbicka J, Zhou Y, Huang Z, Zhang Y, Farjo N, Farjo B, Paus R, Yue Z | J Invest Dermatol. | Read the full story | clinical oncology, hair matrix keratinocytes, Shh signaling, hair follicle damage |
| 2020 | Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? | Paus R, Ramot Y, Kirsner RS, Tomic-Canic M | Exp. Dermatol. | Read the full story | topical hormone therapy, thyroid hormone receptor, L‐thyroxine (T4), skin ulcers, telogen effluvium |
| 2020 | Hair follicle immune privilege and its collapse in alopecia areata | Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R | Exp. Dermatol. | Read the full story | MHC class, mast cells, CD4+, CD8+, NK cell, disease relapse |
| 2020 | Topical Odorant Application of the Specific Olfactory Receptor OR2AT4 Agonist, Sandalore ® , Improves Telogen Effluvium-Associated Parameters | Jimenez F, López E, Bertolini M, Alam M, Chéret J, Westgate G, Rinaldi F, Marzani B, Paus R. | J Cosmet Dermatol. | Read the full story | OR2AT4 olfactory receptor, Sandalore®, claim substantiation, hair growth, hair treatment, telogen effluvium |
| 2020 | Vascular Endothelial Growth factor-A as a Promising Therapeutic Target for the Management of Psoriasis | Luengas-Martinez A, Hardman-Smart J, Paus R, Young HS. | Exp. Dermatol. | Read the full story | angiogenic mediator, bevacizumab, personalised medicine, vascular endothelial growth factor A |
| 2020 | Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo | Post H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R. | Arch Dermatol. Res | Read the full story | hypoxia, skin organ culture, Wound healing, preclinical |
| 2020 | Vascular endothelial growth factor blockade induces dermal endothelial cell apoptosis in a clinically relevant skin organ culture model | Luengas-Martinez A, Hardman-Smart J, Rutkowski D, Purba TS, Paus R, Young HS | Skin Pharmacol Physiol | Read the full story | anti-VEGF, endothelial cell apoptosis, human skin ex vivo, microvascular network, Psoriasis |
| 2020 | Non‐neuronal kappa‐opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo | Chéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus R | J Dermatol | Read the full story | neurogenic inflammation, human skin organ culture, keratinocyte apoptosis, inflammatory dermatoses |
| 2020 | Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis | Oláh A, Alam M, Chéret J, Kis NG, Hegyi Z, Szöllősi AG, Vidali S, Bíró T, Paus R | Exp Dermatol | Read the full story | keratinocyte mitochondrial activity, cannabinoid receptor 1, organ-cultured full-thickness human skin, ROS production, skin aging, photodamage |
| 2020 | Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing | Del Duca E, Ruano Ruiz J, Pavel AB, Sanyal RD, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E. | Br J Dermatol | Read the full story | lesional, nonlesional scalp biopsies, stem cells, follicular damage, JAK/STAT-targeting treatments |
| 2020 | Hair(y) matters in melanoma biology | Barbara Bedogni, Ralf Paus | Trends in Molecular Medicine | Read the full story | metastatic melanoma, melanocytes, immune-privileged microenvironment, stem cells, melanoma prevention strategy |
| 2020 | New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles. | Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus R | Br J Dermatol | Read the full story | human hair, androgenetic alopecia, stress-induced hair loss, hair organ culture model, caffeine |
| 2020 | An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes | Alam M, Bertolini M, Gherardini J, Keren A, Ponce L, Chéret J, Alenfall J, Dunér P, Nilsson AH, Gilhar A, Paus R | Br J Dermatol | Read the full story | human scalp skin xenotransplant, human hair follicle organ culture, hypertrichosis, hirsutism, hair growth |
| 2020 | Adenosine promotes human hair growth and inhibits catagen transition in vitro - role of the outer sheath keratinocytes. | Lisztes E, Toth BI, Bertolini M, Szabo IL, Zakany N, Olah A, Szollosi AG, Paus R, Biro T. | J Invest Dermatol | Read the full story | hair follicle, ex vivo, organ culture, co-immunolabeling, G-protein, hair growth |
| 2020 | Toward predicting the spatio-temporal dynamics of alopecia areata lesions using partial differential equation analysis. | Atanaska Dobreva, Ralf Paus, N. G. Cogan | Bull Math Biol | Read the full story | autoimmune disease, alopecia areata, partial differential equations, humanized mouse model |
| 2020 | Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy? | Cheret J, Gherardini J, Bertolini M, Paus R. | Br J Dermatol | Read the full story | hair follicle, ex vivo, organ culture, quantitative Masson-Fontana histomorphometry, serotonin receptor, melanotropic neurohormone |
| 2020 | Do hair follicles operate as primitive, multifocal kidney-like excretory (mini-)organs? | Carré JL, Suzuki T, Paus R | Exp Dermatol | Read the full story | trichocytes, hair shafts, classical nephrological therapy, erythropoietin synthesis |
| 2020 | Neuroendocrinology and neurobiology of sebaceous gland. | Clayton RW, Langan EA, Ansell DM, de Vos IJHM, Göbel K, Schneider MR, Picardo M, Lim X, van Steensel MAM, Paus R | Biol Rev Camb Philos Soc | Read the full story | nervous system, pituitary control, sebaceous glands, homeostasis |
| 2020 | Phytocannabinoid(-)-Cannabidiol operates as a complex, differential modular of human hair growth: Anti-inflammatory sub-micromolar versus hair growth inhibitory micromolar effects. | Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T | J Invest Dermatol | Read the full story | hair follicle, ex vivo organ culture, toll-like receptor, hair morphology |
| 2020 | Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata. | Laufer BR, Keren A, Paus R, Gilhar A. | Br J Dermatol | Read the full story | hair loss, hair follicle, phosphodiesterase inhibitor, therapeutics |
| 2020 | Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during subtance P-mediated neurogenic inflammation ex vivo. | Gherardini J, Uchida Y, Hardman JA, Cheret J, Mace K, Bertolini M, Paus R | PLoS One | Read the full story | macrophages, full-thickness skin organ culture, immunohistochemistry, neuroinflammatory stimulus |
| 2020 | Schwann cells as underestimated, major players in human skin physiology and pathology. | Bray ER, Cheret J, Yosipovitch G, Paus R. | Exp Dermatol | Read the full story | axon regeneration, wound healing, atopic dermatitis, psoriasis |
| 2020 | Theophylline exerts complex anti-aging and anti-cytotoxicity effects in human skin ex vivo. | Bertolini M, Ramot Y, Gherardini J, Heinen G, Cheret J, Welss T, Giesen M, Funk W, Paus R. | Int J Cosmet Sci | Read the full story | full thickness skin, organ culture, ex vivo, phosphodiesterase inhibitor, metallothionein‐1, collagen, skin‐protective properties |
| 2020 | Pigmentation effects of blue light irradiation on skin and how to protect against them | Campiche R, Curpen SJ, Lutchmanen-Kolanthan V, Gougeon S, Cherel M, Laurent G, Gempeler M, Schuetz R. | Int J Cosmet Sci. | Read the full story | pigmentation, blue light, skin protection |
| 2020 | Topical niacinamide enhances hydrophobicity and resilience of corneocyte envelopes on different facial locations | R Voegeli, D Guneri, M Cherel, B Summers, M E Lane, A V Rawlings | Int J Cosmet Sci. | Read the full story | skin barrier, skin imaging, corneocytes, skin aging, hydrophobicity, clinical evaluation, stripping |
| 2020 | An image-based mapping of significance and relevance of facial skin colour changes of females living in Thailand | P Séroul, R Campiche, S Gougeon, M Cherel, A V Rawlings, R Voegeli | Int J Cosmet Sci. | Read the full story | claim substantiation, facial mapping, relevance, significance, skin colour, statistics |
| 2020 | Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo. | Boukhedouni N, Martins C, Darrigade AS, Drullion C, Rambert J, Barrault C, Garnier J, Jacquemin C, Thiolat D, Lucchese F, Morel F, Ezzedine K, Taieb A, Bernard FX, Seneschal J, Boniface K. | JCI Insight | Read the full story | Autoimmune diseases; Cytokines; Dermatology; Inflammation; Skin. |
| 2020 | An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica. | Awada R, Verdier D, Froger S, Brulard E, de Faria Maraschin S, Etienne H, Breton D. | Sci Rep. | Read the full story | Plant, coffea, high throughput screening |
| 2020 | Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm | Bollinger Caroline., Duong Tu Anh., Genain G., Amalric N., Moga A., Richard W., Vandier S. | Skin Res Technol. | Read the full story | Cosmetics, Prospective Studies, Skin Care, Technology, skin pigmentation, cigarette smoke, environmental stress |
| 2020 | A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coats | Combarros D., Castilla-Castaño E., Lecru La., Pressanti C., Amalric N., Cadiergues Mc. | Plefa (Prostaglandins, Leukotrienes And Essential Fatty Acids) | Read the full story | Canine; Docosahexaenoic acid; Eicosapentaenoic acid; Haircoat; Omega-3 fatty acids; Skin, veterinary medecine. |
| 2020 | A novel method for evaluating the effect of pollution on the human skin under controlled conditions | Curpen S., Francois-Newton V., Moga A., Hosenally M., Petkar G., Soobramaney V., Ruchaia B., Lutchmanen Kolanthan V., Roheemun N., Sokeechand Bn., Aumeeruddy Z., Ramracheya Rd. | Skin Research & Technology | Read the full story | biomarkers; controlled pollution exposure system; cosmetic claims; pollution; skin. |
| 2019 | JAK inhibitors and alopecia areata. | Gilhar A, Keren A, Paus R. | Lancet | Read the full story | systemic therapy, cytokines, autoimmune disease |
| 2019 | Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine. | Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M, Jimenez F, Funk W, Bohm M, Botchkareva NV, Ward C, Paus R, Bertolini M. | Int J Cosmet Sci | Read the full story | ex vivo, organ culture, UV exposure, keratinocyte apoptosis, photoprotectants, clinical relevance |
| 2019 | Nestin(+) progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may stimulate angiogenesis in wounded human skin ex vivo. | Liao T, Lehmann J, Sternstein S, Yay A, Zhang G, Matthiessen AE, Schumann S, Siemers F, Kruse C, Hundt JE, Langan EA, Tiede S, Paus R. | Arch Dermatol Res | Read the full story | skin punch biopsies, ex vivo, wound healing model, pre-clinical, regenerative medicine, chronic skin ulceration |
| 2019 | Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle? | Nicu C, Hardman JA, Pople J, Paus R. | Exp Dermatol | Read the full story | hair follicle, transmission electron microscopy, anagen‐catagen transition, lipogenesis, hair cycle |
| 2019 | Assessment of Quality of Life and Treatment Outcomes of Patients with persistent postchemotherapy alopecia. | Freites-Martinez A, Chan D, Sibaud V, Shapiro J, Fabbrocini G, Tosti A, Cho J, Goldfarb S, Modi S, Gajria D, Norton L, Paus R, Cigler T, Lacouture ME. | JAMA Dermatol | Read the full story | persistent chemotherapy-induced alopecia, clinical study, hair loss, patinets, dermatologic therapy |
| 2019 | Hair growth control by innate immunocytes: Perifollicular macrophages revisited. | Muneeb F, Hardman JA, Paus R. | Exp Dermatol | Read the full story | hair matrix, hair cycle stage, hair follicle morphogenesis, Wnt signalling, clinically relevant |
| 2019 | Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo. | Zhang GY, Langan EA, Meier NT, Funk W, Siemers F, Paus R. | PLoS One | Read the full story | full thickness human skin, wound healing organ culture model, quantitative immunohistomorphometry, pre-clinical testing, keratin expression, energy metabolism |
| 2019 | Distinct patterns of hair graft Survival After Transplantation into 2 Nonhealing Ulcers: Is Location Everything? | Alam M, Cooley J, Plotczyk M, Martinez-Martin MS, Izeta A, Paus R, Jimenez F. | Dermatol Surg | Read the full story | hair follicles, scar formation, hair growth, wound healing, human skin |
| 2019 | Image Gallery: Optical coherence tomography for intravital human hair follicle analyses ex vivo. | Lehmann J, Kemper B, Barroso Pena A, Schnekenburger J, Paus R, Bertolini M, Cheret J. | Br J Dermatol | Read the full story | label‐free, high‐resolution, anatomical details, ex vivo, organ culture, hair matrix |
| 2019 | Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis. | Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G. | Exp Dermatol | Read the full story | hair follicle, mast cells, neurogenic inflammation, psoriatic scalp itch, immunogenic inflammation |
| 2019 | Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis. | Clayton RW, Gobel K, Niessen CM, Paus R, van Steensel MAM, Lim X. | Br J Dermatol | Read the full story | genetic mouse models, mammalian skin, acne vulgaris, comedones, acne pathogenesis |
| 2019 | Hair disorders in patients with cancer. | Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME. | J Am Acad Dermatol | Read the full story | chemotherapy induced alopecia, hair repigmentation, immunotherapies, oncology patients |
| 2019 | Fibrosis and stem cell epithelial-mesenchymal transition in primary cicatricial alopecias. | Harries M, Imanishi H, Paus R. | J Am Acad Dermatol | Read the full story | laser capture microdissection, microarray analysis, hair follicle, immune privilege collapse, follicular inflammation |
| 2019 | TRPV4 is expressed in human hair follicles and inhibits hair growth in vitro. | Szabo IL, Herczeg-Lisztes E, Szegedi A, Nemes B, Paus R, Biro T, Szollosi AG. | J Invest Dermatol | Read the full story | calcium permeable, microflorimetric Ca2+ measurement, outer root sheath keratinocytes, peripheral sensory nerves |
| 2019 | Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo. | Alam M, Below DA, Cheret J, Langan EA, Bertolini M, Jimenez F, Paus R. | J Invest Dermatol | Read the full story | human hair follicle, ex vivo, organ culture, mini-organ, neuropeptides, pigmentation |
| 2019 | Alopecia areata patients show deficiency of FOXP3+CD39+ T regulartory cells and clonotypic restriction of Treg TCRß-chain, which highlights the immunopathological aspect of disease. | Hamed FN, Astrand A, Bertolini M, Rossi A, Maleki Dizaji A, Messanger AG, Mc Donagh AJG, Tazi-Ahnini R. | PloS One | Read the full story | flow cytometry, next Generation Sequencing, hair loss, Treg clonotypes, autoimmune reaction |
| 2019 | Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation. | Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R. | Br J Dermatol | Read the full story | in situ hybridization, human telogen, scalp hair follicle sections, hair biology |
| 2019 | Inhibition of ATP binding cassette transporter B1 sensitizes human hair follicles to chemotherapy-induced damage. | Smart E, Farjo N, Farjo B, Haslam IS, Paus R. | J Dermatol Sci | Read the full story | quantitative immunohistomorphometry, 4-hydroxycyclophosphamide, anthracycline doxorubicin, ex vivo, proliferation, apoptosis |
| 2019 | The Phytocannabinoid (-)-Cannabidiol operates as a complex, differential modulator of human hair qrowth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects. | Szabo IL, Lisztes E, Beke G, Toth KF, Paus R, Olah A, Biro T. | J Invest Dermatol | Read the full story | hair follicle, organ culture, hair shaft, hair cycle, hair matrix keratinocytes |
| 2019 | Seborrheic dermatitis-Looking beyond Malassezia. | Wikramanayake TC, Borda LJ, Miteva M, Paus R. | Exp Dermatol | Read the full story | chronic, relapsing inflammatory, skin disease, Mpzl3 knockout mice, epidermal barrier, sebaceous activity |
| 2019 | CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. | Purba TS, Ng'andu K, Brunken L, Smart E, Mitchell E, Hassan N, O'Brien A, Mellor C, Jackson J, Shahmalak A, Paus R. | EMBO Mol Med | Read the full story | hair follicle, organ culture, epithelial bulge stem cell analysis, chemotherapy, paclitaxel, docetaxel, mitotic defects |
| 2019 | PPAR-Y signalling as a key mediator of human hair follicle physiology and pathology. | Ramot Y, Bertolini M, Bobolijava M, Uchida Y, Paus R. | Exp. Dermatol | Read the full story | hair follicle development, scarring alopecia, epithelial-mesenchymal transition, androgenetic alopecia |
| 2019 | Precilinal evidence that PPARγ- modulator, N-Acetyl-GED-0507-34-Levo, may protect human hair follicle epithelial stem cells against lichen planopilaris -associated damage. | Cheret J, Piccini I, Hardman-Smart J, Ghatak S, Alam M, Lehmann J, Jimenez F, Erdmann H, Poblet E, Botchkareva N, Paus R, Bertolini M. | J Eur Acad Dermatol Vernereol | Read the full story | hair follicle, ex vivo, organ culture, immunohistochemistry, NAGED, hair loss, lichen planopilaris |
| 2019 | Mineralocorticoid receptor antagonists stimulate human hair growth ex vivo. | Hundt JE, Sass S, Funk W, Biro T, Farman N, Langan EA, Paus R. | Skin Pharmacol Physiol | Read the full story | hair follicle, ex vivo, organ culture, glucocorticoid, hair cycle |
| 2019 | Y-27632 preserves epidermal intregity in a human skin-organ culture (h-SOC) system by regulating AKT and ERK signalling pathways. | Zang X, Qin J, Xie Z, Liu C, Su Y, Chen Z, Zho Q, Ma C, Liu G, Paus R, Guo J, Wu X. | J Dermatol Sci | Read the full story | human breast skin, organ culture, ex vivo, epidermal cell proliferation, immunofluorescence staining, ROCK inhibitor, epidermal architecture |
| 2019 | Frontiers in alopecia areata pathobiology research. | Gilhar A, Britva RL, Keren A, Paus R. | J Allergy Clin Immunol | Read the full story | humanized mouse model, autoantigens, regulatory T cells, immune privilege |
| 2019 | Human perifollicular macrophages undergo apoptosis, express Wnt ligands and switch their polarization during catagen. | Hardman JA, Muneeb F, Pople J, Bhogal R, Shahmalak A, Paus R. | J Invest Dermatol | Read the full story | human hair follicle, ex vivo, organ culture, hair cycle, inflammatory hair disease |
| 2019 | Model-based approach to the design of pharmaceutical roller-compaction processes. | Toson P, Lopes DG, Paus R, Kumar A, Geens J, Stibale S, Quodbach J, Kleinebudde P, Hsiao WK, Khinast J. | Int J Pharm | Read the full story | mathematical model, in-silico, ibuprofen formulations, iterative calibration |
| 2019 | Comparing skin characteristics and molecular markers of xerotic foot skin between diabetic and non-diabetic subjects: An exploratory study | Lechner A. , Akdeniz M. , Tomova-Simitchieva T. , Bobbert T. , Moga A. , Lachmann N., Blume-Peytavi U., Kottner J. | Journal Of Tissue Viability | Read the full story | Dermatology; Diabetes mellitus; Diabetic foot; Dry skin; Molecular markers; Skin barrier, pharma |
| 2019 | The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity | Reynier M., Allart S., Goudounèche D., Moga A., Serre G., Simon M., Leprince C. | Journal Of Investigative Dermatology | Read the full story | Skin, epidermal barrier, dermatology |
| 2019 | Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin | Pin D., Pendaires V., Alassane Sk., Froment C., Amalric N., Cadiergues Mc., Serre G., Haftek M., Vidémont E., Simon M. | Journal Of Histochemistry & Cytochemistry | Read the full story | atopic dermatitis, differentiation, keratinocyte, skin, veterinary medicine |
| 2019 | Appearance of aging signs in differently pigmented facial skin by a novel imaging system | Remo Campiche, Solène Trevisan, Pierre Séroul, Anthony V Rawlings, Cyprien Adnet, Dominik Imfeld, Rainer Voegeli | J Cosmet Dermatol | Read the full story | anti‐aging, Black African skin, Caucasian skin, ColorFace®, Ethnic, facial imaging, pores, skintone, wrinkles |
| 2019 | Facial skin mapping: from single point bio-instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types | R Voegeli, J Gierschendorf, B Summers, A V Rawlings | Int J Cosmet Sci. | Read the full story | claim substantiation, Epilobium fleischeri, microbiota, reference frames, skin care, skin microbiome |
| 2019 | Cosmetics increase skin evenness: Evidence from perceptual and physical measures | Carlota Batres, Aurélie Porcheron, Julie Latreille, Magalie Roche, Frédérique Morizot, Richard Russell | Skin Res Technol | Read the full story | cosmetics, skin imaging |
| 2019 | Three-dimensional maps of human skin properties on full face with shadows using 3-D hyperspectral imaging | Lou Gevaux, Cyprien Adnet, Pierre Séroul, Raphael Clerc, Alain Trémeau, Jean Luc Perrot, Mathieu Hébert | J Biomed Opt | Read the full story | Skin, 3D image processing, 3D acquisition Cameras, Reflectivity, Hyperspectral imaging Calibration, Chromophores, 3D scanning, Scattering |
| 2019 | Bio-derived hydroxystearic acid ameliorates skin age spots and conspicuous pores | R Schütz, A V Rawlings, E Wandeler, E Jackson, S Trevisan, J-M Monneuse, I Bendik, M Massironi, D Imfeld | Int J Cosmet Sci. | Read the full story | age spots, chemical synthesis, computer modelling, hydroxystearic acid, pores, skin physiology/structure |
| 2018 | Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-alpha administration differ during wound repair and regeneration. | Abarca-Buis RF, Martinez-Jimenez A, Vera-Gomez E, Contreras-Figueroa ME, Garciadiego-Cazares D, Paus R, Robles-Tenorio A, Krotzsch E. | Differentiation | Read the full story | ear punch wound mouse model, histology analysis, fibrotic scarring, epidermal apoptosis |
| 2018 | Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management. | Paus R, Bulfone-Paus S, Bertolini M. | J Investig Dermatol Symp Proc | Read the full story | hair bulb, pharmacological manipulation, Immune privilege collapse-related autoimmune diseases |
| 2018 | An efficient method for eccrine gland isolation from human scalp. | Jimenez F, Alam M, Hernandez I, Poblet E, Hardman JA, Paus R. | Exp Dermatol | Read the full story | hair graft harvesting method, calp follicular unit grafts, microdissection, methylene blue staining |
| 2018 | NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types. | Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. | J Invest Dermatol | Read the full story | humanized mouse model, hair cycle analysis, histological techniques, anagen induction, telogen−anagen transition |
| 2018 | Eccrine sweat glands associate with the human hair follicle within a defined compartment of dermal white adipose tissue. | Poblet E, Jimenez F, Escario-Travesedo E, Hardman JA, Hernandez-Hernandez I, Agudo-Mena JL, Cabrera-Galvan JJ, Nicu C, Paus R. | Br J Dermatol | Read the full story | 3D reconstruction, human scalp, follicular unit transplant grafts, scalp strip ex vivo, human skin adnexa |
| 2018 | Epithelial-to-mesenchymal stem cell transition in a human organ: Lessons from lichen planopilaris. | Imanishi H, Ansell DM, Cheret J, Harries M, Bertolini M, Sepp N, Biro T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R. | J Invest Dermatol | Read the full story | hair follicle, ex vivo organ culture, immunohistochemistry, transmission electron microscopy, preclinical assay |
| 2018 | Prolactin as a candidate sebotrop(h)ic hormone? | Langan EA, Hinde E, Paus R. | Exp Dermatol | Read the full story | human dermatoses, sebaceous gland, therapeutic strategies, cutaneous ageing |
| 2018 | A guide to studying human dermal adipocytes in situ. | Nicu, C, Pople J, Bonsell L, Bhogal R, Ansell DM, Paus R. | Exp Dermatol | Read the full story | quantitative immunohistomorphometry, dermal white adipose tissue, in situ hybridization, neuroendocrinology |
| 2018 | Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture. | Parodi C, Hardman JA, Allavena G, Marotta R, Catelani T, Bertolini M, Paus R, Grimaldi B. | PLoS Biol | Read the full story | cell culture, quantitative immunohistomorphometry, ex vivo, knockdown, preclinical research model |
| 2018 | Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg total deletion. | Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. | J Invest Dermatol | Read the full story | humanized mouse model, skin grafts, in vivo, gene expression, adipose tissue-mediated signals |
| 2018 | Melatonin: A cutaneous perspective on its production, metabolism, and functions. | Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R. | J Invest Dermatol | Read the full story | hair follicle, photo-protection, anti-cancer activity, wound healing, pigmentation, inflammatory dermatoses |
| 2018 | Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. | Foster AR, Nicu C, Schneider MR, Hinde E, Paus R. | Arch Dermatol Res | Read the full story | in vivo BODIPY, immunohistomorphometry, wound healing, adipocyte hypertrophy |
| 2018 | Lichen planopilaris and frontal fibrosing alopecia as model epithelial stem cell diseases. | Harries MJ, Jimenez F, Izeta A, Hardman J, Panicker SP, Poblet E, Paus R. | Trends Mol Med | Read the full story | hair follicle, PPAR-γ, epithelial-mesenchymal transition, immune-privilege |
| 2018 | Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. | Hawkshaw NJ, Hardman JA, Haslam IS, Shahmalak A, Gilhar A, Lim X, Paus R. | PLoS Biol | Read the full story | hair follicle, ex vivo organ culture, Quantitative immunohistomorphometry, bioinformatics, immunosuppressant, therapeutic strategy |
| 2018 | How UV light touches the brain and endocrine system through skin, and why. | Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R. | Endocrinology | Read the full story | environmental factors, UV radiation, body homeostasis, neuro-endocrine system |
| 2018 | Image Gallery: Intravital visualization of the dynamic changes in human hair follicle cycling. | Alam M, Hernandez I, Paus R, Jimenez F. | Br J Dermatol | Read the full story | anagen, catagen, telogen, methylene blue staining, hair cycle stage |
| 2018 | Topically applied nicotinamide inhibits human hair follicle growth ex vivo. | Haslam IS, Hardman JA, Paus R. | J Invest Dermatol | Read the full story | organ culture, microdissected human scalp hair follicles, hair growth inhibitor, catagen, mast cells |
| 2018 | Re-investigating the basement membrane zone of psoriatic epidermal lesions: Is laminin-511 a new player in psoriasis pathogenesis? | Natsumi A, Sugawara K, Yasumizu M, Mizukami Y, Sano S, Morita A, Paus R, Tsuruta D. | J Histochem Cytochem | Read the full story | skin tumorectomy, immunohistochemistry, transmission electron microscopy, laminin-511, keratinocyte growth/death |
| 2018 | Cover Image: Neuroendocrine treatment of inherited keratin disorders by cannabinoids? | Ramot Y, Olah A, Paus R. | Br J Dermatol | Read the full story | uman skin organ culture, ex vivo, epidermolytic ichthyosis, keratin disorders, cannabinoid signalling |
| 2018 | iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata. | Ghraieb A, Keren A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. | J Autoimmun | Read the full story | humanized mouse model, xenotransplants, lymphocytes, therapeutic potential |
| 2018 | Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin. | Keren A, Shemer A, Ginzburg A, Ullmann Y, Schrum AG, Paus R, Gilhar A. | J Allergy Clin Immunol | Read the full story | humanized mouse model, sublethal irradiation, immunohistochemical analysis, cytokine analyses, psoriatic lesions |
| 2018 | Peroxisome Proliferator-Activated Receptor-gamma-Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium. | Ramot Y, Alam M, Olah A, Biro T, Ponce L, Cheret J, Bertolini M, Paus R. | J Invest Dermatol | Read the full story | ex vivo organ culture, gene expression, N-Acetyl-GED, mitochondrial function, ORS keratinocytes |
| 2018 | Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. | Dobreva, A, Paus R, Cogan NG. | Math Med Biol | Read the full story | mathematical modelling, anagen phase interruption, therapeutic targets |
| 2018 | Visualization of global RNA synthesis in a human (mini-) organ in situ by click chemistry. | Purba TS, Marsh J, Ng'andu K, Kurinna S, Paus R. | Biotechniques | Read the full story | human hair follicle, ex vivo organ culture, in situ RNA synthesis, 5-ethynyl uridine |
| 2018 | Bridging the "Dead hair"-"live follicle" divide in applied hair research. | Bertolini M, Botchkareva N, Westgate G, Ward C, Cornwell P, Paus R. | J Cosmet Sci | Read the full story | synopsis, mini-organ, hair shaft structure |
| 2018 | Olfactory receptor OR2AT4 regulates human hair growth. | Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R. | Nat Commun | Read the full story | ex vivo, organ culture, knockdown, histological analysis, genome-micro array analysis, sandalore, synthetic sandalwood, hair growth, hair loss therapy |
| 2018 | A technique for more precise distinction between catagen and telogen human hair follicles ex vivo. | Hernandez I, Alam M, Platt C, Hardman J, Smart E, Poblet E, Bertolini M, Paus R, Jimenez F. | J Am Acad Dermatol | Read the full story | ex vivo organ culture, hair cycle stage, macroscopic analysis |
| 2018 | Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. | Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. | Cell Rep | Read the full story | computational analysis, single-cell RNAseq, keratinocyte |
| 2018 | Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P-induced human mast cell activation and degranulation in the hair follicle. | Jadkauskaite L, Bahri R, Farjo N, Farjo B, Jenkins G, Bhogal R, Haslam I, Bulfone-Paus S, Paus R. | J Allergy Clin Immunol | Read the full story | ex vivo organ culture, immunohistochemistry, mast cells degranulation and activity assay, neuropeptide, androgenetic alopecia, alopecia areata |
| 2018 | Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex. | Romano, MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmuller J, Nurnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lutjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. | Am J Hum Genet | Read the full story | whole-exsome sequencing, alopecia, cholesterol biosynthetic pathway, lanosterol synthase |
| 2018 | The renaissance of human skin organ culture: A critical reappraisal. | Zhou L, Zhang X, Paus R, Lu Z. | Differentiation | Read the full story | ex vivo, morphological analyses, gene silencing, assays |
| 2018 | Is prolactin a negative neuroendocrine regulator of human skin re-epithelisation after wounding? | Langan EA, Fink T, Paus R. | Arch Dermatol Res | Read the full story | ex vivo, human skin organ culture, PRL receptor antagonists, keratinocyte differentiation |
| 2018 | Retinoic acid co-treatment aggravates severity of dioxin-induced skin lesions in hairless mice via induction of inflammatory response. | Rudyak SG, Usakin LA, Tverye EA, Orekhov AS, Belushkina NN, Paus R, Paltsev MA, Panteleyev AA. | Biochem Biophys Res Commun | Read the full story | humanized mouse model, halogenated polyaromatic hydrocarbons, skin pathologies, keratinocyte |
| 2018 | SpectraCam® : A new polarized hyperspectral imaging system for repeatable and reproducible in vivo skin quantification of melanin, total hemoglobin, and oxygen saturation | A Nkengne, J Robic, P Seroul, S Gueheunneux, M Jomier, K Vie | Skin Res Technol | Read the full story | hemoglobin, hyperspectral imaging, in vivo melanin quantification |
| 2018 | Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression. | Simonneau M, Frouin E, Huguier V, Jermidi C, Jégou JF, Godet J, Barra A, Paris I, Levillain P, Cordier-Dirikoc S, Pedretti N, Bernard FX, Lecron JC, Morel F, Favot L. | Oncotarget. | Read the full story | cytokine; immunotherapy; oncostatin M; skin cancer; tumor microenvironment. |
| 2018 | Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles. | Daull P, Guenin S, Hamon de Almeida V, Garrigue JS. | Mol Vis. | Read the full story | inflammation, drug delivery, eye, wound healing |
| 2018 | Clinical Efficacy of a Novel Two-Part Skincare System on Pollution-Induced Skin Damage | Makino Et., Jain A., Tan P., Nguyen A., Moga A., Charmel C., Kadoya K., Cheng T., Mehta Rc. | J Drugs Dermatol | Read the full story | Skin aging, pollutants, environmental stress, skin care, oxidative stress, apoptose, inflammation, skin barrier |
| 2018 | Cerebrovascular β-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet | Hur J., Mateo V., Amalric N., Babiak M., Béréziat G., Kanony-Truc C., Clerc T., Blaise R., Limon I. | The Faseb Journal | Read the full story | 12-HETE; cerebral amyloid angiopathy; docosahexaenoic acid; vascular smooth muscle cells, Alzheimer, mouse model, pharma |
| 2018 | Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis | Garcia M, Morello E, Garnier J, Barrault C, Garnier M, Burucoa C, Lecron JC, Si-Tahar M, Bernard FX, Bodet C | Virulence | Read the full story | Bacterial pathogenesis; antimicrobial peptides; chemokines; cytokines; flagellin; human keratinocytes; type 2 secretion system; type 3 secretion system. |
| 2017 | Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. | Haslam IS, Jadkauskaite L, Szabo IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Biro T, Schafer M, Paus R. | J Invest Dermatol | Read the full story | human hair follicle, organ culture, ex vivo, quantitative immunofluorescence, ROS, keratinocytes |
| 2017 | Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. | Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nothen MM. | Nat Commun | Read the full story | geno-wide analysis, meta-analysis, hair follicle cycling, therapeutics |
| 2017 | Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology. | Jumper N, Hodgkinson T, Paus R, Bayat A. | PLoS One | Read the full story | site-specific in situ microdissection, transcriptome array analysis, 2D cell culture, TGFβ-mediated signaling |
| 2017 | Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation. | Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. | J Invest Dermatol | Read the full story | Human punch biopsy, wound healing, microarray analysis, in vivo repair, neuroblastoma |
| 2017 | Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata? | Bertolini M, Rossi A, Paus R. | Br J Dermatol | Read the full story | hair follicle, hair matrix melanocytes, mast cells, autoantigens, melanogenesis |
| 2017 | Regulatory T cells in skin facilitate epithelial stem cell differentiation. | Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. | Cell | Read the full story | immune-profiling, immunofluorescent microscopy, in vivo mouse model, skin inflammation, telogen-anagen transition, Jagged 1, hair regeneration, alopecia areata |
| 2017 | Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1beta-mediated signaling. | Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. | Heliyon | Read the full story | incisional wound induction, histological analysis, cytokine injection, Gene expression profiling, hair cycle, IL-1β signaling |
| 2017 | Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. | Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H. | Exp Dermatol | Read the full story | human keratinocytes culture, cAMP‐dependent pathway, skin diseases, wound repair |
| 2017 | Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? | Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS. | Bioessays | Read the full story | redox homeostasis, NRF2 activation, hair follicle pathologies |
| 2017 | E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis. | Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. | J Invest Dermatol | Read the full story | human skin biopsy, footpad mouse model, in vivo rescue, epidermal keratinocytes, radiotherapy |
| 2017 | Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. | Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Ceballos L, Gandarillas A, Paus R | Eur J Cell Biol | Read the full story | human hair follicle, ex vivo organ culture, in situ hybridisation, CIP/KIP proteins, hair bulb growth |
| 2017 | T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. | Oelert T, Gilhar A, Paus R. | Exp Dermatol | Read the full story | hair follicle, immune privilege collapse, CD4+ regulatory T cells, alopecia areata |
| 2017 | A role for neuregulin-1 in promoting keloid fibroblast migration via ErbB2-mediated signaling. | Jumper N, Hodgkinson T, Paus R, Bayat A. | Acta Derm Venereol | Read the full story | laser capture microdissection, in situ gene expression profiling, NRG1/ErbB2/Src/PTK2 signaling pathway, fibroproliferative tumour |
| 2017 | Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2. | Purba TS, Peake M, Farjo B, Farjo N, Bhogal RK, Jenkins G, Paus R. | Sci Rep | Read the full story | ex vivo, hair follicle organ culture, Immunofluorescence, Quantitative immunohistomorphometry, epithelial stem cells |
| 2017 | New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic Sciences | Jouravel G., Guénin S., Bernard Fx., Elfakir C., Bernard P., Himbert F. | Cosmetics 2017, 4(52) | Read the full story | Lythrum salicaria L.; purple loosestrife; natural extract; vescalagin; skin barrier function; epidermis; differentiation; TGK; 3D model |
| 2017 | Development of a new model of reconstituted mouse epidermis and characterization of its response to proinflammatory cytokines. | Pohin M, Veaute C, Garnier J, Barrault C, Cronier L, Huguier V, Favot L, Mcheik J, Bernard FX, Lecron JC, Morel F, Jégou JF. | J Tissue Eng Regen Med | Read the full story | cytokine; keratinocyte; reconstituted epidermis; skin inflammation; three-dimensional culture. |
| 2017 | Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis. | Couderc E, Morel F, Levillain P, Buffière-Morgado A, Camus M, Paquier C, Bodet C, Jégou JF, Pohin M, Favot L, Garcia M, Huguier V, Mcheik J, Lacombe C, Yssel H, Guillet G, Bernard FX, Lecron JC | PLoS One | Read the full story | NHEK, inflammation, psoriasis, cytokines |
| 2017 | A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne | Bouloc A., Roo E., Imko-Walczuk B., Moga A., Chadoutaud B., Dreno B. | Jeadv | Read the full story | Acne Vulgaris, Emollients, Humans, Lipid Metabolism, Skin, Skin Care, dermatology, pharma |
| 2017 | A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study | Bouloc A., Roo E., Moga A., Chadoutaud B., Zouboulis Cc. | Acta Dermato-Venereologica | Read the full story | https://jddonline.com/articles/clinical-efficacy-of-a-novel-two-part-skincare-system-on-pollution-induced-skin-damage-S1545961618P0975X/ |
| 2017 | Novel approaches to characterize age-related remodelling of the dermal-epidermal junction in 2D, 3D and in vivo | V L Newton, R S Bradley, P Seroul, M Cherel, C E M Griffiths, A V Rawlings, R Voegeli, R E B Watson, M J Sherratt | Skin Res Technol | Read the full story | skin ageing, X-ray computed tomography, reflectance confocal microscopy, dermal-epidermal junction, photodamage, rete ridge, dermal papilla |
| 2016 | Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialization. | Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. | Stem Cells | Read the full story | wound healing, transgenic mice, in vivo |
| 2016 | An innovative approach to dissecting keloid disease leading to identification of the retinoic acid pathway as a potential therapeutic target. | Jumper N, Paus R, Bayat A. | Plast Reconstr Surg Glob Open | Read the full story | skin biopsies, laser capture microdissection, epidermis |
| 2016 | A Guide to studying human hair follicle cycling in vivo. | Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. | J Invest Dermatol | Read the full story | pre-clinical, xenograft, immuno-histochemistry |
| 2016 | Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. | Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. | Development | Read the full story | gene expression, transcriptome, embryos, cell migration |
| 2016 | Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. | Dahlhoff M, Camera E, Schafer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. | Development | Read the full story | gene targeting, mouse line, in vivo, meibomian gland disease |
| 2016 | p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a rat model of radiation dermatitis. | Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. | J Invest Dermatol | Read the full story | chip analysis, in vivo, therapeutic targeting, dermatoses |
| 2016 | Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. | Bertolini M, Pretzlaff M, Sulk M, Bahr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Biro T, Paus R. | Br J Dermatol | Read the full story | hair follicle organ culture, immuno‐histomorphometry, autoimmune disorder |
| 2016 | A primer for studying cell cycle dynamics of the human hair follicle. | Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. | Exp Dermatol | Read the full story | immuno-labelling, cell cycle, proliferation, apoptosis |
| 2016 | Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue. | Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A. | J Invest Dermatol | Read the full story | molecular diagnostic, biomarker, immunohistochemistry, dermal scarring |
| 2016 | Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. | Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R. | Autoimmun Rev | Read the full story | xenografts, transplantation, SCID mice, therapeutic strategies |
| 2016 | The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease. | Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. | J Invest Dermatol | Read the full story | laser capture microdissection, microarray, luciferase assay, metabolism |
| 2016 | The gut-skin axis in health and disease: A paradigm with therapeutic implications. | O'Neill CA, Monteleone G, McLaughlin JT, Paus R. | Bioessays | Read the full story | microbiota, signaling pathways, skin co‐morbidities |
| 2016 | The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo. | Olah A, Gherardini J, Bertolini M, Cheret J, Ponce L, Kloepper J, Biro T, Soeberdt M, Abels C, Paus R. | J Invest Dermatol | Read the full story | human scalp hair follicle, organ culture, hair cycle, translational human hair research |
| 2016 | Exploring the "brain-skin connection": Leads and lessons from the hair follicle. | Paus R. | Curr Res Transl Med | Read the full story | human hair follicle, organ culture, neuro-hormone, skin epithelium, Melatonin |
| 2016 | Biology of the eyelash hair follicle: an enigma in plain sight. | Paus R, Burgoa I, Platt CI, Griffiths T, Poblet E, Izeta A. | Br J Dermatol | Read the full story | mini-organ culture, greying, cosmetic manipulation |
| 2016 | Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis. | Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E. | PLoS Genet | Read the full story | siRNA, NOTCH1 reporter assay, knockdown in mice hair follicles, organ cultures, apoptosis, ectodermal dysplasias |
| 2016 | Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? | Poblet E, Jimenez-Acosta F, Hardman JA, Escario E, Paus R. | Exp Dermatol | Read the full story | 3D imaging, scalp follicular units, skin appendages |
| 2016 | Thyroid hormones enhance mitochondrial function in human epidermis. | Vidali S, Cheret J, Giesen M, Haeger S, Alam M, Watson REB, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. | J Invest Dermatol | Read the full story | Human skin organ culture, ex vivo, immunohistochemistry, Transmission electron microscopy, In situ zymography, skin aging, mitochondrial function |
| 2016 | Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. | Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. | Matrix Biol | Read the full story | Hair follicle formation, histological analysis, electron microscopy, mouse model, hair shaft differentiation, basement membrane |
| 2016 | Identification of new morphological differences between Chinese and Caucasian faces and influence of BMI on these characteristics | A Machard, M Jomier, D Hottelart, K Vié | Skin Res Technol | Read the full story | Caucasian, Chinese, face morphology, BMI average, face ultrasound analysis, fringe projection |
| 2016 | Rab11a Is Essential for Lamellar Body Biogenesis in the Human Epidermis | Reynier M. , Allart S. , Gaspard E. , Moga A. , Goudounèche D., Serre G., Simon M., Leprince C. | Journal Of Investigative Dermatology | Read the full story | Cells, Cultured, Epidermis, metabolism, Gene Silencing, Homeostasis / genetics, Humans, Keratinocytes / cytology, Organelle Biogenesis, Sampling Studies, Tissue Culture Techniques,rab GTP-Binding Proteins / genetics* |
| 2016 | Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition | Jourdain R., Moga A., Vingler P., El Rawadi C., Pouradier F., Souverain L., Bastien P., Amalric N., Breton L. | Arch Dermatol Res | Read the full story | Dandruff scalp; Lipids; Malassezia; Oxidative stress; Sebum; Squalene peroxide. |
| 2016 | Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts. | Mcheik JN, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, Morel F, Lecron JC, Bernard FX. | J Tissue Eng Regen Med. | Read the full story | burns; differentiation; foreskin; graft; keratinocytes; proliferation. |
| 2016 | Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast. | Régnacq M, Voisin P, Sere YY, Wan B, Soeroso VMS, Bernard M, Camougrand N, Bernard FX, Barrault C, Bergès T. | Biochem Biophys Res Commun. | Read the full story | Autophagy; Fatty acid; Fatty acid synthase; Lipid droplets; Rapamycin; Saccharomyces cerevisiae. |
| 2016 | Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation | Pohin M, Guesdon W, Mekouo AA, Rabeony H, Paris I, Atanassov H, Favot L, Mcheik J, Bernard FX, Richards CD, Amiaud J, Blanchard F, Lecron JC, Morel F, Jégou JF. | Eur J Immunol. | Read the full story | Imiquimod · Keratinocyte · Oncostatin M · Psoriasis · Skin inflammation. |
| 2015 | IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome | Rabeony H, Pohin M, Vasseur P, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F. | Eur J Immunol. | Read the full story | IL-1R; Imiquimod; MyD88; NLRP3 inflammasome; Skin inflammation. |
| 2015 | A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups | R Voegeli, A V Rawlings, P Seroul, B Summers | Int J Cosmet Sci. | Read the full story | ethnic, facial colour mapping, skin barrier, skin hydration, stratum corneum, transepidermal water loss |
| 2015 | Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor. | Barrault C, Garnier J, Pedretti N, Cordier-Dirikoc S, Ratineau E, Deguercy A, Bernard FX. | J Steroid Biochem Mol Biol. | Read the full story | Androgen; Apoptosis; Differentiation; Lipid; Receptor; Sebocyte. |
| 2015 | IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells. | Akil H., Abbaci A., Lalloué F., Bessette B., Costes Lm., Domballe L., Charreau S., Guilloteau K., Karayan-Tapon L., Bernard Fx., Morel F., Jauberteau Mo., Lecron Jc. | PLoS ONE, 10(3) | Read the full story | Lung and intrathoracic tumors, Colorectal cancer, Apoptosis, Hepatocellular carcinoma, Cell proliferation, Gastric cancer, Phosphorylation, Renal cancer |
| 2015 | Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis | Le Lamer M., Pellerin L., Reynier M., Cau L., Pendaires V., Leprince C., Mechin Mc., Serre G., Paul C., Simon M. | Biol. Chem. | Read the full story | atopic dermatitis, corneocytes, eczema, epidermal barrier, filaggrin, keratinocytes, skin inflammation |
| 2015 | In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification | Pendaires V., Le Lamer M., Cau L., Hansmann B., Malaisse J., Kezic S., Serre G., Simon M. | Cell Death And Disease | Read the full story | skin, epidermis, filaggrin, corneocytes, 3D model |
| 2014 | Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation | Pendaires V., Malaisse J., Pellerin L., Le Lamer M., Nachat R., Kezic S., Schmitt Am., Paul C., Poumay Y., Serre G., Simon M. | Journal Of Investigative Dermatology | Read the full story | atopic dermatitis, epidermal barrier, keratinocye differentiation, filaggrin, RHE, 3D model, corneocyte, UV-B, environmental stress |
| 2014 | Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M. | Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou JF, Guillet G, Huguier V, Lecron JC, Bernard FX, Morel F. | PLoS One | Read the full story | skin, keratinocyte, differeciation, epidermal barrier, inflammation |
| 2014 | Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children | Mcheik JN, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, Morel F, Bernard FX, Lecron JC. | Burns | Read the full story | 3D model, epidermis, keratinocyte |
| 2014 | Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective | Mcheik Jn, et al. | Plast Reconstr Surg Glob Open. | Read the full story | wound healing, keratinocyte, transplantation, sun burn, skin |
| 2013 | Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression. | Debiais-Delpech C., Godet J., Pedretti N., Bernard Fx., Irani J., Cathelineau X., Cussenot O. And Fromont G. | Urologic Oncology | Read the full story | prostate, cancer cells, proliferation |
| 2013 | Contribution of IL-22 to Experimental Skin Inflammation. | Lecron Jc., Paris I., Bernard Fx. And Morel F. | Progress in Inflammation Research: ‘IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity’, Springer Basel, 305-317. | Read the full story | skin inflammation, IL-22, interleukine, autoimmunity, inflammatory skin disease, psoriasis |
| 2013 | Involvement of IL-1 and Oncostatin M in acanthosis associated to Hypertensive Leg Ulcer. | Giot Jp., Paris I., Levillain P., Huguier V., Charreau S., Delwail A., Garcia M., Bernard Fx., Dagregorio G., Guillet G., Morel F., Lecron Jc. And Favot L. | The American Journal of Pathology, 182(3):806-18 | Read the full story | Hyper tensive leg ulcer, inflammatory disease, epidermis acanthosis, cytokine |
| 2013 | Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts. | Mcheik Jn., Barrault C., Pedretti N., Garnier J., Juchaux F., Levard G., Morel F., Lecron Jc., Bernard Fx. | Journal of tissue engineering and regenerative medicine | Read the full story | keratinocytes foreskin burns graft proliferation differentiation |
| 2012 | Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis | Bernard FX, Morel F, Camus M, Pedretti N, Barrault C, Garnier J, Lecron JC | J Allergy (Cairo) | Read the full story | Skin, keratinocyte, immune cells, inflammation, atopic dermatitis, psoriasis, skin morphology, cytokines |
| 2012 | Cystinosin is a Melanosomal Protein That Regulates Melanin Synthesis. | Chiaverini C., Sillard L., Flori E., Ito S., Briganti S., Wakamatsu K., Fontas E., Berard E., Cailliez M., Cochat P., Foulard M., Guest G., Niaudet P., Picardo M., Bernard Fx., Antignac C., Ortonne Jp. And Ballotti R. | The FASEB Journal, 26(9):3779-89 | Read the full story | pigmentation, melanocytes, melanogenesis, tyrosinase, cytonosis |
| 2012 | Immortalized sebocytes can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium. | Barrault C., Dichamp I., Garnier J., Pedretti N., Juchaux F., Deguercy A., Agius G. And Bernard Fx. | Experimental Dermatology, 21(4):314-6 | Read the full story | 3D model, differentiation, keratinocyte, sebocyte, skin |
| 2012 | The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells. | Lamiche C., Clarhaut J., Strale Po., Crespin S., Pedretti N., Bernard Fx., Naus C., Chen V., Foster L., Defamie N., Mesnil M., Debiais F. And Cronier L. | Clinical & Experimental Metastasis, 29(2):111-22 | Read the full story | prostate, cancer cells, proliferation |
| 2012 | siRNA-mediated allele-specific inhibition of mutant type VII collagen in dominant dystrophic epidermolysis bullosa | Pendaires V., Gasc G., Titeux M., Tonasso L., Mejía Je., Hovnanian A. | Journal Of Investigative Dermatology | Read the full story | atopic dermatitis, differentiation, keratinocyte, skin, veterinary medicine |
| 2011 | Black patients of African descent and HLA-DRB1*15:03 frequency overrepresented in epidermolysis bullosa acquisita | Zumelzu C., Le Roux-Villet C., Loiseau P., Busson M., Heller M., Aucouturier F., Pendaires V., Lièvre N; Pascal F., Brette M. D., Doan S., Charron D., Caux F., Laroche L., Petit A., Prost-Squarcioni C. | Journal Of Investigative Dermatology | Read the full story | Autoimmune disease, skin, skin of color, skin condition |
| 2011 | Deimination of human filaggrin-2 promotes its proteolysis by calpain 1 | Hsu Cy., Henry J., Raymond Aa., Méchin Mc., Pendaires V., Nassar D., Hansmann B., Balica S., Burlet-Schiltz O., Schmitt Am., Takahara H., Paul C., Serre G., Simon M. | The Journal Of Biological Chemistry | Read the full story | Calpain, Differentiation, Mass Spectrometry (MS), Post-translational Modification, Protease, Skin, Corneocytes, Epidermis, Keratinocytes, Peptidylarginine Deiminase |
| 2011 | Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study. | Deloche C., Minondo Am., Bernard Ba., Bernerd F., Salas F., Garnier J. And Tancrède E. | European Journal of Dermatology, 21(2):191-6 | Read the full story | skin ageing, dermal epidermal junction, C-xyloside, Laminin 332, α 6-integrin subunit |
| 2011 | CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions. | Ghannam S., Dejou C., Pedretti N., Giot Jp., Dorgham K., Boukhaddaoui H., Deleuze V., Bernard Fx., Jorgensen C., Yssel H. And Pène J. | The Journal of Immunology, 186(3):1411-20 | Read the full story | Inflammation, endothelium, skin cytokine, lymphocytes |
| 2010 | Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns. | Mcheik Jn., Barrault C., Bernard Fx. And Levard G. | Burns, 36(8):1277-82 | Read the full story | skin burns, pediatric, foreskin keratinocytes, 2D model |
| 2010 | Skin inflammation induced by the synergistic action of IL-17A, IL-22, OSM, IL-1α and TNFα recapitulates some features of psoriasis. | Guillotteau K., Paris I., Pedretti N., Boniface K., Juchaux F., Huguier V., Guillet G., Bernard Fx., Lecron Jc. And Morel F. | The Journal of Immunology, 184(9):5263 -5270 | Read the full story | Skin, inflammation, cytokines, keratinocytes, in vitro model, psoriasis, transcriptional analysis |
| 2010 | Immune reactivity to type VII collagen: implications for gene therapy of recessive dystrophic epidermolysis bullosa | Pendaires V., Gasc G., Titeux M., Leroux C., Vitezica Zg, Mejía Je., Décha A., Loiseau P., Bodemer C., Prost-Squarcioni C., Hovnanian A. | Gene Therapy | Read the full story | Skin condition, collagen, immunity, sensitivity |
| 2009 | Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study. | Guenou H., Nissan X., Larcher F., Feteira J., Lemaitre G., Saidani M., Del Rio M., Barrault C., Bernard Fx., Peschanski M., Baldeschi C. And Waksman G. | The Lancet, 374(9703):1745-1753 | Read the full story | burns, graft, reconstructed epidermis, stem cells, preclinical study |
| 2009 | Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. | Rahmoun M., Molès Jp., Pedretti N., Mathieu M., Fremaux I, Raison-Peyron N., Lecron Jc., Yssel H. And Pène J. | Journal of Investigative Dermatology, 129(3):671-81 | Read the full story | skin, psoriasis, inflammation, keratinocytes, neutrophils, in vitro 2D model, reconstructed epidermis |
| 2009 | Cultured keratinocyte cells from foreskin and future application for burns in children. | Mcheik Jn., Barrault C., Vincent G., Grammatico F., Peci S., Garnier J., Bernard Fx., Deguercy A. And Levard G. | Annales de chirurgie plastique et esthétique, 54(6):528-32 | Read the full story | burns, graft, foreskin keratinocytes, in vitro study |
| 2008 | Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE). | Dallas C., Gerbi A., Tenca G., Juchaux F. And Bernard Fx. | Phytomedicine, 15(10):783-92 | Read the full story | dietary supplement, lipolytic effect, lipolysis, adipocytes, ex vivo model, clinical study, sinetrol, cAMP phosphodiesterase |
| 2008 | Keratinocytes as targets for cytokines in skin inflammation. | Lecron Jc., Morel F., Boniface K. And Bernard Fx. | Recent Advances in Skin Immunology", S. Saeland. Ed. | Read the full story | - |
| 2008 | Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction. | Saintigny G., Bernard Fx., Juchaux F., Pedretti N. And Mahé C. | Experimental Dermatology, 17(9):788-9 | Read the full story | dermal fibroblast, collagen, 2D model, skin aging, Hayflick sennescence model |
| 2008 | A frequent functional SNP in the MMP1 promoter is associated with higher disease severity in recessive dystrophic epidermolysis bullosa | Matthias Titeux M., Pendaires V., Tonasso L., Décha A., Bodemer C., Hovnanian A. | Human Mutation | Read the full story | Skin condition, collagen, immunity, sensitivity, MMP1, fibroblast |
| 2007 | A role for T cell-derived interleukin 22 in psoriatic skin inflammation. | Boniface K., Morel F., Pedretti N., Garcia M., Guignouard E., Guillet G., Dagregorio G., Yssel H., Bernard Fx., Delwail A., Nau F. And Lecron Jc. | Clinical and Experimental Immunology, 150(3):407-15 | Read the full story | cytokines, inflammation, psoriasis, skin disease, T cells |
| 2007 | Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. | Boniface K., Diveu C., Morel F., Pedretti N., Froger J., Ravon E., Garcia M., Venereau E., Preisser L., Guignouard E., Guillet G., Dagregorio G., Pene J., Moles J-P., Yssel H., Chevalier S., Bernard Fx., Gascan H. And Lecron Jc. | The Journal of Immunology, 178(7):4615-22 | Read the full story | skin inflammation, T lymphocytes, keratinocytes, psoriasis |
| 2007 | Moclobemide attenuates anoxia and glutamate induced neuronal damage in vitro independently of interaction with glutamate receptors subtypes. | Verleye M., Steinschneider R., Bernard Fx. And Gillardin Jm. | Brain Research, 1138:30-38 | Read the full story | Anoxia, glutamate neurotransmission, neuroprotective, compound evaluation |
| 2006 | In-vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cells | Jourdain C, Tenca G, Deguercy A, Troplin P, Poelman D | Eur J Cancer Prev. | Read the full story | prostate, cancer cells, proliferation |
| 2005 | Keratinocytes as targets for IL-10-related cytokines : a putative role in psoriasis pathogenesis. | Boniface K., Lecron Jc., Bernard Fx., Dagregorio G., Guillet G., Nau F. And Morel F. | European Cytokine Network | Read the full story | cytokines, skin, keratinocyte, inflammation, psoriasis |
| 2005 | Alternative (non-animal) methods for cosmetic testing: current status and future prospects. | Gribaldo L., Gennari A., Blackburn K., Clemedson C., Deguercy A., Meneguz A., Pfaller W. And Ruhdel I. | Alternatives to Laboratory Animals, 33 (S1) Chapter 3.1, Acute Toxicity: 27-34 | Read the full story | Cosmetic testing, non-animal testing |
| 2005 | Alternative (non-animal) methods for cosmetic testing: current status and future prospects. | Liebsch M., Spielmann H., Pape W., Krul C., Deguercy A. And Eskes C. | Alternatives to Laboratory Animals, 33(S1) Chapter 3.8, UV-induced Effects: 131-46 | Read the full story | Cosmetic testing, non-animal testing |
| 2005 | Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing. | Bernard FX, Barrault C, Juchaux F, Laurensou C, Apert L. | J Wound Care | Read the full story | skin, fibroblast, dermis, cell proliferation, wound healing |
| 2002 | Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis. | Bernard Fx., Pedretti N., Rosdy M. And Deguercy A. | Experimental Dermatology, 11(1):59-74 | Read the full story | skin, reconstructed epidermis, transcriptional analysis, 3D in vitro model, RHE |
| 2000 | Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis | Bernard FX, Barrault C, Deguercy A, De Wever B, Rosdy M | Cell Biol Toxicol. | Read the full story | RHE, reconstructed epidermis, 3D model, skin, UVA, environmental stress, reconstructed tissue |
| 2000 | Expression of type 1 5alpha-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic(R)): a new model for screening skin-targeted androgen modulators | Bernard FX, Barrault C, Deguercy A, de Wever B, Rosdy M. | Int J Cosmet Sci. | Read the full story | RHE, reconstructed epidermis, 3D model, skin, reconstructed tissue |
