A QIMA Life Sciences tem muitos modelos in vitro ou ex vivo à sua disposição:
- queratinócitos epidérmicos humanos normais (NHEK)
- epiderme humana reconstruída (RHE)
- sebócitos (SEBO662AR)
- pele de espessura completa (FTSK)
- explantes de pele (ex vivo)
nos quais podemos avaliar individualmente o efeito hidratante dos compostos ativos ou das formulações por medir:
- o reforço da função de barreira
- a estimulação da diferenciação epidérmica (por exemplo, filagrina, involucrina, transglutaminase, citoqueratinas)
- síntese de lipídeo (manto ácido):
- lipídeos sebáceos
- lipídeos epidérmicos (por exemplo, ceramidas, cerebrosídeos e fosfolipídeos)
- a expressão ou a síntese dos componentes da matriz extracelular epidérmica:
- glicosaminoglicanos e ácido hialurônico
- proteoglicanas e receptores de ECM
- proteases (por exemplo, MMPs)
- a expressão dos marcadores de coesão epidérmica e junções intracelulares:
- junções oclusivas e proteínas de acoplamento (claudina, ocludina, desmogleínas etc.)
- junção dermoepidérmica (por exemplo, integrina V, colágeno IV, colágeno VII etc.)
- junções comunicantes (por exemplo, conexinas) e canais moleculares (por exemplo, aquaporinas)
Aqui estão alguns exemplos dentre todos os ensaios padrões propostos pela QIMA Life Sciences sobre hidratação e reforço da função de barreira:
Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Expression de gènes, Skin barrier and hydrationHelichrysum italicum (Roth) G. Don subsp. italicum (H. italicum italicum) from the Asteraceae family grows on dry, rocky or sandy ground around the Mediterranean Basin and is commonly known as the everlasting plant.
Facial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types
Barrière cutanée et hydratation, Cosmetics, CosmétiqueDry skin is one of the most important concerns of consumers worldwide. Despite huge efforts over several decades, the personal care industry still does not offer a perfect solution to satisfy the unmet needs of consumers for moisturising treatments in different ethnic groups.
Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Barrière cutanée et hydratation, Médecine vétérinaire, Skin barrier and hydration, Veterinary medicineFilaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis.
New Biological Activities of Lythrum salicaria L.
Barrière cutanée et hydratation, Cosmetics, Cosmétique, Skin barrier and hydrationThe perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine.
La glande sébacée : Physiologie et fonctions
Acné, Barrière cutanée et hydratation, Peau grasse, hyperséborrhée et séborégulationLa glande sébacée est un organe localisé au niveau du derme. Elle est responsable de la synthèse et de la sécrétion du sébum qui entre dans la composition du film hydrolipidique. Le rôle du sébum est de protéger la peau des agressions extérieures et de la déshydratation. Le sébum permet également d’entretenir la souplesse de la peau et des cheveux.
New biological effects of Aphloïol
Barrière cutanée et hydratation, Cosmetics, Cosmétique, Skin barrier and hydrationIn the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
Rab11a Is Essential for Lamellar Body Biogenesis in the Human
Barrière cutanée et hydratation, Skin barrier and hydrationMost of the skin barrier function is attributable to the outermost layer of the epidermis, the stratum corneum, which is composed of flattened, anucleated cells called corneocytes surrounded by a lipid-enriched lamellar matrix.