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Related Publications
SELECTED PUBLICATIONS ON PSORIASIS
Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin
>> Check the full list HERE.
Conference Contributions
We share our research on dermatology and trichology through international conferences and publications, contributing to the advancement of research in these fields.
>> Check our past contributions HERE.
Preclinical Research Solutions for Psoriasis
IN VITRO MODELS
Modeling psoriasis like responses in vitro:
- Normal Human Epidermal Keratinocytes (NHEK)
- Reconstructed Human Epidermis (RHE)
- Immune cells from healthy and psoriatic human blood
EX VIVO MODELS
Ex vivo skin explants, including:
Skin samples from both healthy volunteers and psoriasis patients
(lesional and peri-lesional), experimentally-induced psoriasis in skin explants, human skin re-innervated skin explants
IN VIVO MODELS
- Imiquimod induced mouse model
- Humanized mouse model
Created through a collaboration with Prof. Amos Gilhar at the Skin Research Laboratory (Technion Israel Institute of Technology, Haifa, Israel)
Clinical Research Solutions for Psoriasis
BIOANALYSIS OF CLINICAL SAMPLES
- Non-invasive clinical samples (sbabbing, tape stripping, patches)
- Clinical biospecimens (biopsiesa, blood) and prostaglandins analysis
- Skin imaging and clinical phenotyping
- Multiomics analysis: genomics, proteomics, lipidomics, metabolomics, spatial proteomics and transcriptomic analysis
CLINICAL IMAGING & IMAGE ANALYSIS
- Monitoring lesions in psoriasis patients by tracking changes in skin morphology over time
- Quantitatively evaluating the efficacy of treaments
CLINICAL TRIALS
Phases I–IV, from early safety and tolerability studies to efficacy, biomarker, and postmarketing research
Psoriasis Study Examples
Secukinumab reduces mRNA levels of IL36G in Normal Human Epidermal Keratinocytes (NHEK)
Test: Gene expression
Method: RNA seq
Model: Normal Human Epidermal Keratinocytes (NHEK)
Interpretation of results: cytokine cocktail induces psoriasis-associated gene expression in human epidermal keratinocytes.
Reconstructed Human Epidermis (RHE) mimicking skin diseases
Test: Expression of filaggrin (FLG)
Method: Immunofluorescence staining
Model: Reconstructed human epidermis (RHE)
Interpretation of results: the stimulation with IL-17, IL-22 and TNF-α reduces the expression of filaggrin in RHE in vitro.
Investigating the effect of a drug on lesional skin from psoriasis patients ex vivo
Test: CD3+ cells in peri-lesional and lesional skin
Method: Immunofluorescence staining
Model: Human skin ex vivo organ culture
Interpretation of results: the psoriasis phenotype of patient skin is maintained during ex vivo organ culture.
Amelioration of disease after treatment with Dexamethasone
Test: Expression of Ki-67 and HLA-DR
Method: Immunohistochemistry (IHC)
Model: Humanized mouse model
Interpretation of results: Dexamethasone reduces cellular proliferation ex vivo.
Characterization of psoriatic skin
Test: SkinCam® digital imaging
Method: SkinCam® digital imaging
Model: Psoriatic lesion
Interpretation of results: localized SkinCam® imaging provides objective and quantitative measures that can complement clinical evaluation and help detect subtle treatment effects.
At QIMA Life Sciences, we are committed to staying at the forefront of dermatology research by developing innovative approaches.
We offer smart solutions for studying psoriasis using validated models at both preclinical and clinical stages, making us the perfect partner for your research.
Explore All Our Models & Assays in Our Brochure
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DERMATOLOGY DRUG DISCOVERY AND DEVELOPMENT– From Target Identification to Clinical Trials
