Preclinical & Clinical Research in Dermatology
We can support you with:
Target Identification
We offer state-of-the-art techniques, e.g. (single cell) RNAseq, laser capture microdissection, applied to healthy and diseased tissue samples and pre-clinical models to identify novel targets in skin and hair disorders that can be modulated by pharmaceutical, cosmeceutical or nutraceutical compounds.
Target Characterization
We offer state-of-the-art techniques, e.g. in situ hybridization, multiplex immunostainings, applied to healthy and diseased tissue samples and pre-clinical models to examine the source, expression and localization of your target of interest in healthy and diseased skin and hair samples.
Target Validation
We offer pre-clinical models, and state-of-the-art techniques, including gene silencing ex vivo, to study if modulation of your target of interest provides an efficient therapeutic benefit on skin and hair pathology within an acceptable safety window.
Mechanism of Action and Proof-of-Concept
We offer pre-clinical models to identify the underlying molecular mechanisms in skin and hair samples addressed by your target.
Screening of Bioactive compounds
Biomarker identification
We use state-of-the-art techniques and pre-clinical models, including organ culture of diseased skin samples to identify and establish biomarkers as early indicators for skin and hair disease progression.
Predictor of Response & Disease Course
We use pre-clinical models, including organ culture of diseased skin samples, to predict treatment responses induced by your target of interest, in skin and hair pathologies.
Comparative Studies (Repositioning or Benchmarking Studies)
We offer pre-clinical models to examine the efficacy and safety of your compound on targets of interest in comparison to well known agents.
Efficacy Testing
We offer pre-clinical models to test if the modulation of your target of interest efficiently affects skin and hair biology, ameliorates experimentally-induced pathological conditions or the phenotype of diseased samples.
Biodistribution
We offer pre-clinical models to investigate the localization and distribution of your compound/drug/nutraceutical in skin and hair samples to support the selection of best mode or vehicle for administration.
Establishment of Assays
We are happy to help you in customizing assays to optimally meet your research needs, and to join forces to establish clinically-meaningful models.
We are constantly working on the establishment of new assays,
in vitro Safety Assays (non-GLP)
Evaluation of Biosimilars
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