Our techniques
We offer the possibility of combining gene expression profiling with in situ evaluation of mRNA expression, and protein expression and activity (in situ hybridization, immuno-histomorphometry, in situ zymography) within a single experiment.
We can also examine the impact of test agents, exogenous and endogenous modulators, and environmental stressors on hair follicle responses. Thanks to our expertise you will be able to perform functional mechanism of action (MoA) assays and study molecular targets using specific agonists, antagonists, neutralizing antibodies, and targeted gene silencing (siRNA).
Finally, through advanced microdissection techniques we can investigate and identify hair follicle-associated cell populations (such as hair matrix keratinocytes, outer root sheath keratinocytes, and dermal papilla fibroblasts) that specifically respond to treatment.
Our selection of current hair research and testing models
- Hair growth and pigmentation
- Hair follicle stem cell differentiation and activities
- Hair follicle immune privilege (relevant for diseases like alopecia areata and scarring alopecia)
- Hair follicle epithelial transition (relevant for research in diseases like scarring alopecia)
- Interaction of skin or blood-isolated immune cells with different hair follicle compartments (relevant for conditions such as alopecia areata, scarring alopecia, acne, and hidradenitis suppurativa)
- Effects of environmental stressors on the hair follicle (including UV radiation, H2O2, and pollutants)
Scientific Publications on Human Hair Follicles
Lousada et al., 2023, Horesh et al, 2022, Wikramanayake et al., 2022, O’Sullivan et al., 2022, Smart et al., 2020, Purba et al., 2020, Hundt et al., 2020, Chéret et al., 2020, Fischer et al., 2020, Szabó et al., 2020, Lisztes et al., 2020, Bertolini et al., 2020, Haslam et al., 2020, Hardman et al., 2020, Cheret et al., 2019, Ramot et al.,2019, Lisztes et al., 2019, Hawkshaw et al.,2019, Purba et al., 2019, Lehmann et al., 2019, Alam et al., 2020, Olah et al. 2016, Bertolini et al. 2016, Oh et al. 2016, Purba et al. 2016, Langan et al. 2015, Kloepper et al. 2010
You want to learn more about our hair explants and associated assays?
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