- CNS Inflammation
- Peripheral inflammation, sensitivity, pain, itching
- Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis
- Ischemia and stroke
- Epilepsy
- Peripheral neuropathies
- Parkinson’s disease
- Alzheimer’s disease
- Demyelinating diseases and multple sclerosis
- Neuromuscular diseases
- Atopic dermatitis
- Psoriasis
in vitro models for neurobiology
SNC, neuronal primary cultures (rat) :
- cortical neurons
- dopaminergic neurons
- hippocampal neurons
- mesencephalic neurons
SNC, glial primary cultures (rat) :
- astrocytes
- oligodendrocytes and oligodendrocyte precursor cells
- brain microglia cells
SNP, neuronal primary cells (rat) :
- sensory neurons
- motoneurones
- dorsal root ganglia (sensory neurons)
Cocultures and mixed-cultures
- cortical neurons and oligodendrocytes, mixed culture
- cortical neurons and astrocytes, mixed culture
- cortical neurons, oligodendrocytes and astrocytes, mixed culture
- sensory neurons and schwann cells, mixed cutlure
- epithelial cells and neuronal cells, coculture
- glial cells and neuronal cells, coculture
- mesenchymial cells and neuronal cells, coculture
Cells lines:
- PC12
- SH-SY5Y
- SK-N-SH
- NGP
Ex vivo models:
- human hair explant
- human skin explant
- completely humanized human skin-re-innervation model
Neurobiology, in vitro pharmacology assays
- Maturation and differentiation of neural progenitor cell
- Expression of neuromediators and corresponding receptors
- Release of neuromediators
- Expression of neuromodulation-specific channels and proteins associated with mechanotransduction, and neuromediator production and release from nerve fibers
- Expression of markers associated with cutaneous nerve fiber subtypes (myelinated, unmyelinated, peptidergic, non-peptidergic)
- Regulation of skin and hair follicle physiology
