Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
Molecular Vision 2018, 24:459‐470
DAULL P., GUENIN S., HAMON DE ALMEIDA V., GARRIGUE JS. (2018)
SANTEN SAS, Novagali Innovation center, 1, rue Pierre Fontaine, Bâtiment Genavenir IV, F-91058 Evry Cedex, France.
Bioalternatives, Gençay, France.
Preservative-free cationic emulsion-based artificial tears (ATs) or drug vehicles are innovative eye drop formulations with tear film stabilization and drug delivery properties, and valuable in vivo anti-inflammatory and wound healing properties. These ATs have recently reached the market as ATs for the management of dry eye disease (DED) symptoms (i.e., Cationorm) or as a drug vehicle for cyclosporine (Ikervis). The aim of the present study was to explore the mechanism of action underlying the intrinsic anti-inflammatory and wound-healing efficacies harbored by the cationic emulsions of cetalkonium chloride (CE-CKC).
© 2018 Molecular Vision
KEYWORDS: CKC; Eye Drop