Slimming &

Adipocyte Metabolism

Your beauty and well-being products

backed by trust and efficacy.

Slimming products and weight loss are contemporary issues and the cosmetic industry strives to research and develop innovative solutions with a proven effect. Slimming and keeping trim are an important concern for many women and men. As hypodermis, also called subcutaneous white adipose tissue, represents 15 to 25 % of a person’s weight, it is the primary target of slimming products.

Adipose tissue is mostly composed of mature adipocytes whose primary function is to store (lipogenesis) and to release (lipolysis) lipids according to the energy needs of the body. Adipose tissue is also composed of undifferentiated cells, mesenchymal stem cells and preadipocytes which can acquire the phenotype and functions of a mature adipocyte via a process called adipogenesis.

A cosmetic product or active ingredient can therefore directly or indirectly act on adipose tissue through different modes of action, such as:

  • lipolysis activation (lipid release)
  • lipogenesis inhibition (storage limitation and/or lipid neosynthesis)
  • adipogenesis (adipocyte differentiation modulation)

Slimming effect and adipocyte metabolism: in vitro models and assays

QIMA Life Sciences s has many in vitro and ex vivo models at your disposal:

  • 3T3L1 cell line
  • mesenchymal stem cells (hMSCs)
  • human preadipocytes
  • human differentiated adipocytes
  • isolated adipocytes (ex vivo)

on which we can evaluate the slimming effect of active compounds on:

  • lipolysis (release)
  • lipogenesis (storage)
  • adipocyte differentiation
  • adipocyte conversion (browning)
A project, an idea or a question? Contact us and let’s talk about it!

Hello! How can we help you?

It takes less than a minute to ask us your question.

We will get back to you shortly!

(Required)
Keep up with what's happening in QIMA Life Sciences?(Required)
Terms of Services(Required)
This field is for validation purposes and should be left unchanged.