Skin microcirculation and vascularization - Cosmetic efficacy studies

SKIN MICROCIRCULATION

& VASCULARIZATION

Skin microcirculation is located in the dermis and hypodermis layers. It plays a significant role in skin homeostasis (transportation of gases, nutrients, waste, hormones), in body thermoregulation, in blood pressure regulation and in inflammatory response.

Dermal arterioles and venules are composed of endothelial cells, connective tissues (collagen, elastin) and of smooth muscle cells which allow vessel vasoconstriction and vasodilation. Dermal capillaries are composed of a single layer of endothelial cells and of pericytes surrounded by a basal membrane.

A microcirculation dysfunction due to external factors (e.g. sun exposure, heat, cold, microorganisms and food) or internal factors (immune system) can cause redness, venous insufficiency or rosacea. Microcirculation is also altered by skin ageing, with a progressive decrease of new blood vessel formation (angiogenesis). This age-related alteration of skin microcirculation may have different consequences: sensation of cold, pallor, cutaneous ischemia, alopecia, etc.

Skin microcirculation and vascularization: in vitro models and assays

QIMA Life Sciences has many in vitro models at your disposal:

Human umbilical vein endothelial cells (HUVEC)
Human dermal microvascular endothelial cells (HMVEC-d)
HMVEC-d and NHDF coculture (ENDOF)
Human aortic smooth muscle cells (AoSMC)
Other skin cells (NHEK, NHDF, etc.)

on which we can evaluate the effect of active cosmetic compounds on skin microvascularization by measuring:

Viability, proliferation and migration of endothelial cells
Cell differentiation and pseudotube (angiogenesis, neovascularization) formation
Protection of endothelial cells against stress (inflammation, infection, etc.)
Veinotonic activity of smooth muscle cells
Angiogenic factor release (e.g.VEGF)

Here are a few examples among all assays proposed by QIMA Life Sciences in the field of microvascularization:

Find out about all our standard assays - Direct access to catalog A project, an idea or a question? Contact us and let’s talk about it!

Need more information?

Surname*
Company*
Email*
Country*
Phone number
Services Needed :*
Stay informed!*
- Yes
- No
The information collected on this form is recorded in a computerized file by QIMA LIFE SCIENCES to contact you in order to respond to your request and assist you in selecting the test or tests best suited to your project. The legal basis for processing is the legitimate interest of QIMA Life Sciences. The data collected will be communicated only to the following recipients: The services concerned and authorized by QIMA Life Sciences. The data is retained for a period of 3 years from the collection or your last incoming contact. You can access your data, correct it, request its deletion or exercise your right to limit the processing of your data, withdraw your consent to the processing of your data at any time, object to the processing of your data, and have a right to data portability. Visit cnil.fr for more information about your rights. To exercise these rights, you can contact us using the following link Rights Management or by writing to dpo-qima@agencergpd.eu. If you believe, after contacting us, that your "Computer and Freedoms" rights are not respected, you can file a complaint with the CNIL. N.B: The following categories of data: Email / Country Select the replay you wish to view are mandatory. Failure to provide this information will make it impossible for QIMA Life Sciences to respond to you.*
The information collected on this form is recorded in a computerized file by QIMA LIFE SCIENCES to contact you in order to respond to your request and assist you in selecting the test or tests best suited to your project. The legal basis for processing is the legitimate interest of QIMA Life Sciences. The data collected will be communicated only to the following recipients: The services concerned and authorized by QIMA Life Sciences. The data is retained for a period of 3 years from the collection or your last incoming contact. You can access your data, correct it, request its deletion or exercise your right to limit the processing of your data, withdraw your consent to the processing of your data at any time, object to the processing of your data, and have a right to data portability. Visit cnil.fr for more information about your rights. To exercise these rights, you can contact us using the following link Rights Management or by writing to dpo-qima@agencergpd.eu. If you believe, after contacting us, that your "Computer and Freedoms" rights are not respected, you can file a complaint with the CNIL. N.B: The following categories of data: Email / Country Select the replay you wish to view are mandatory. Failure to provide this information will make it impossible for QIMA Life Sciences to respond to you.
I have read and accept the Terms of Service of qima-lifesciences.com
CAPTCHA
Name
This field is for validation purposes and should be left unchanged.

Cookie	Duration	Description
cookielawinfo-checkbox-advertising	11 Months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Advertising".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Others".
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
pll_language	1 year	used by the site to identify the current user language and display page accordingly.
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Cookie	Duration	Description
_GA - Google Analytics	2 years	These cookies set by Google Analytics are used for analytics purposes, including identifying each unique user and details of each page visited. For more information on Google Analytics cookies, see the Google Inc's privacy policy at http://www.google.com/policies/privacy/. You can block the use of Google Analytics cookies by downloading and installing the relevant extra component for your browser from this link: https://tools.google.com/dlpage/gaoptout
_GID - Google Analytics	1 day	Ce cookie est utilisé par Google Analytics à des fins d'analyses comme par exemple pour identifier chaque utilisateur unique et le détail de chaque page visitée. Pour plus d'information sur les cookies de Google Analytics, vous pouvez consulter la politique de vie privée de Google Inc à l'adresse suivante : http://www.google.com/policies/privacy/. Vous pouvez bloquer l'usage des cookies de Google Analytics en téléchargeant et en installant les composants complémentaires pour votre navigateur internet à l'adresse suivante : https://tools.google.com/dlpage/gaoptout

SKIN MICROCIRCULATION

& VASCULARIZATION

Skin microcirculation and vascularization: in vitro models and assays

AoSMC, veinotonic activity (basal)

HUVEC, ICAM-1 expression (TNF- alpha stimulation)

NHDF, VEGF release (basal)

HMVEC + NHDF, differentiation/pseudotube formation (basal, pro-angiogenic agents)

HMVEC + NHDF, differentiation/pseudotube formation (VEGF stimulation, anti-angiogenic agents)

Contact Us

Follow Us

Cosmetics & Personal Care

Pharma & Biotech

NUTRACEUTICALS

Search