Ensemble des articles de QIMA Life Sciences traitant de la biologie de la peau ainsi que des modèles cellulaires et tests in vitro d’intérêts pour l’évaluation de l’efficacité des produits et ingrédients cosmétiques

Metrology

Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm

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According to the International Bureau of Weights and Measurements, metrology, the study of measurement, is becoming an essential aspect of all industries today in creating value.

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

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Loss of melanocytes is the pathological hallmark of vitiligo.

Canitie et pigmentation des cheveux

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La canitie (grisonnement des cheveux) a un large impact social et cosmétique. QIMA Life Sciences présente ici sa physiopathologie, ses causes sous-jacentes et ses traitements.

Profiling TLR agonist activity in keratinocytes and link to bacteria-induced innate immunity activation

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In this study, our goal was first to functionally profile and characterize the response of normal human keratinocytes (NHEK) to microbial patterns (TLR agonists) and IL-1α in parallel. To do so, the effects of multiple TLR agonists and IL-1α were evaluated on the gene expression profile, on signal transduction (NF-ƘB translocation) and also on IL-8 and IL-6 release. Secondly, we also tried to link these responses to those of pathogens of interest in skin microbiota (namely, C. acnes, S. aureus and P. aeruginosa), by evaluating the effect on IL-8 release by NHEK infected with living bacteria from these 3 strains...

Facial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types

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Dry skin is one of the most important concerns of consumers worldwide. Despite huge efforts over several decades, the personal care industry still does not offer a perfect solution to satisfy the unmet needs of consumers for moisturising treatments in different ethnic groups.

Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.

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Acne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.

Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.

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Androgens are key regulators of sebaceous function... A link between mTOR and androgen signaling has previously been reported...as well as a link between these processes and lipid synthesis...Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.
Dog Skin - Epidermal Cornification Proteins

Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin

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Filaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis.

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

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Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous infection.

New Biological Activities of Lythrum salicaria L.

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The perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine.
lipid

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

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Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.

Acné vulgaris : Physiopathologie et mécanismes cellulaires

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L’acné vulgaris est une pathologie inflammatoire chronique cutanée localisée au niveau du follicule pilo-sébacé. Elle apparaît suite à une surproduction de sébum liée à des dysfonctionnements d’origine hormonale (androgène), environnementale (pollution…) et à la colonisation du follicule pilo-sébacé par certaines bactéries (P. acnes). (Dans ce contexte), QIMA Life Sciences a développé un panel de tests originaux destinés à la découverte et l’évaluation de composés pour le traitement de l’acné.
glande sébacée

La glande sébacée : Physiologie et fonctions

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La glande sébacée est un organe localisé au niveau du derme. Elle est responsable de la synthèse et de la sécrétion du sébum qui entre dans la composition du film hydrolipidique. Le rôle du sébum est de protéger la peau des agressions extérieures et de la déshydratation. Le sébum permet également d’entretenir la souplesse de la peau et des cheveux.

Le cheveu: follicule, structures associées et croissance

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Le follicule pileux est une annexe de la peau qui a la capacité de se renouveler de manière parfaitement autonome, cyclique et asynchrone. L'analyse histologique de l'unité pilo-sébacée révèle une organisation en deux compartiments: le compartiment d'origine épithélial et le compartiment d'origine mésenchymale.

New biological effects of Aphloïol

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In the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
skin photoaging irradiations

in vitro modeling of skin photoaging: development of evaluation tools for cosmetics

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Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.
ageing reconstructed epidermis

Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds

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The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
Rab11

Rab11a Is Essential for Lamellar Body Biogenesis in the Human

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Most of the skin barrier function is attributable to the outermost layer of the epidermis, the stratum corneum, which is composed of flattened, anucleated cells called corneocytes surrounded by a lipid-enriched lamellar matrix.
Scalp surface lipids

Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition

Dandruff is a common but complex disorder with three major contributing factors: (1) individual predisposition, (2) scalp sebum and (3) Malassezia yeast colonization.