Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract

Catherine KERN1, Erwan LE GÉLÉBART2, Laetitia CATTUZZATO, Sevda CORDIER-DIRIKOC3, Nathalie PEDRETTI3, François-Xavier BERNARD3, Sandy DUMONT1, Carla PEREZ4

1SEPPIC – Innovation Direction – 127 chemin de la Poudrerie BP90228, 81105 Castres cedex, France


2BiotechMarine – Innovation Direction – ZI BP72, 22260 Pontrieux, France

3Bioalternatives SAS – 1bis rue des plantes – BP N°50011, 86 160 Gençay, France

4SEPPIC – 819 West Nanjing Rd, Room 1508 Zhongchuang Building, Shangai 200041, China


Pollution is a global health concern. Skin, being the interface between body and environment, is challenged everyday by atmospheric pollutants (particulate matters , toxic gases, indoor pollutants,…) which contribute to skin disorders such as psoriasis, atopic dermatitis, skin cancer, skin ageing, pigmentary disorders and acne [1–4].

Pollutants are supposed to act through 4 biological mechanisms:

  • generation of free radicals
  • induction of inflammatory cascades
  • activation of aryl hydrocarbon receptor (AhR)lipid
  • alteration of cutaneous microflora [5, 6].

Our previous investigations showed that:

  • Both sebocytes lipid production and skin sebum production are stimulated by some pollutants.
  • Ame* acts as a urban life dermopurifying ingredient, by protecting epidermal cells from cadmium, human sebocytes from urban dust and skin from ozone.

Materials & Methods

lipid production

Results & Discussion

1) Lipid droplet formation

lipid production
Pollution: Increase lipid formation.

Ame: Decrease lipid formation (with urban dust)

2) Neutral lipidic neosynthesis

lipid production
lipid production
Conversion of fatty acids into triglycerides:
   Increase with pollution
   Decrease with Ame
lipid production

3) Transcriptomic regulations (24h)

lipid production
lipid production
Only a few regulations observed with pollutants or Ame.
    Putative regulated mechanisms:
         antioxydant defenses


lipid productionv
Our results:

Enlighten new pollution-induced metabolic regulation of the lipid profile of stimulated sebocytes.

Suggest that underlying mechanisms are more likely to occur at the metabolic level than at the transcriptional level.

Faites le plein d‘expériences en suivant toute l’actualité de Bioalternatives

  • Nouveaux tests, modèles et services
  • Articles et publications
  • Evènements