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SKIN AGEING

Skin ageing is a natural, multifactorial and still little-known process which results both from intrinsic factors (genomic, hormonal, etc.) and from external aggravating factors (UV radiation, pollution, food, free radicals, etc.). The latter are referred to as accelerated ageing or as photo-ageing in the particular case of UVs.

Intrinsic ageing and accelerated ageing have slightly different phenotypic characteristics. Intrinsic ageing is characterized by skin dryness, fine wrinkles and a loss of adipose tissue. Photo ageing is characterized by a significant loss of firmness and elasticity (loose skin), deeper wrinkles and pigmentation disorders.

In the past few years, significant progress has been made in the understanding of cell ageing mechanisms and we can now explore new dermo-cosmetics strategies which might prevent or decelerate the signs of ageing.

Skin ageing: available models and assays

in silico assays

in vitro
and ex vivo
assays & skin ageing

Biochemical analysis
& skin ageing

Clinical imaging
& skin ageing

in vitro models & assays

QIMA Life Sciences has many in vitro models at your disposal:

  • intrinsic ageing model:
    • “aged” human dermal fibroblasts (Hayflick model)
    • “aged” dermal equivalent (Hayflick model)
  • accelerated ageing model:
    • human dermal fibroblasts aged by oxidative stress (H2O2)
    • human reconstructed skin in deficient medium
  • photo-ageing model:
    • human dermal fibroblasts subjected to UVA, infrared or UV radiation
    • photo-aged human full thickness reconstructed skin

on which we can evaluate the anti-ageing effect of active cosmetic compounds on:

  • cell renewal (cell proliferation, migration and differentiation)
  • extracellular matrix synthesis and degradation (collagen, elastin, hyaluronic acid, MMPs, etc.)
  • senescence marker expression
  • free radical production

Here are a few examples among all standard assays proposed by QIMA Life Sciences in the field of skin ageing:

  • MMP1 gene expression

    NHDF, gene expression (UVA stimulation)

    1.00€
    Add to cart Show Details
  • ELN gene expression

    “Aged” fibroblasts, control of aging (basal)

    1.00€
    Add to cart Show Details
  • MMP-1 release

    Fibroblasts, prevention of aging, procollagen I and/or MMP-1 synthesis (H2O2 stimulation)

    1.00€
    Add to cart Show Details
  • Hyaluronic acid synthesis #

    “Aged” fibroblasts, control of aging, hyaluronic acid synthesis (basal)

    1.00€
    Add to cart Show Details
  • Procollagen I release

    “Aged” fibroblasts, reversion of aging, procollagen I and/or MMP-1 synthesis (basal)

    1.00€
    Add to cart Show Details

Biochemical analysis of non-invasive clinical samples

Analysis of lipids involved in the barrier function

Our company has developed ready-to-use non-invasive collection kits to analyze the lipids and biomarkers of the skin surface from your samples or from those of your clinical center.

The epidermal lipids involved in the barrier function of the epidermis (ceramides, fatty acids and cholesterol) are removed using the SW Kit.

The analysis of these lipids makes it possible to evaluate the quality of the intercorneocyte cement involved in the barrier function of the epidermis and in the prevention of transepidermal water loss (TEWL).

These evaluations help support your claims about the efficacy of biomimetic products, barrier products, protective products, moisturizers, etc.

Analysis of the components of the Natural Moisturizing Factor (NMF)

The amino acids and minerals present on the surface of the skin are collected using the SW Kit:

  • PCA / UCA (cis/trans) – (catabolites of filaggrin)
  • Amino acids
  • Urea, lactates
  • Mineral elements: Ca, K, Na, Mg, Zn, etc.

The analysis of these compounds makes it possible to evaluate the impact of the NMF component on skin hydration

These analysis help support your claims about the efficacy of hygroscopic products, barrier products, protective products, moisturizers, etc.

Analysis of markers of oxidative stress

Oxidative stress is also a factor of accelerated skin ageing. Oxidative stress markers are analyzed from samples using the SW Kit. The sampling areas depend on the type of stress (induced stress or external environment).

The analyzed markers are:

  • products from peroxidation and lipid detoxification (MDA, peroxidized squalene, CAT, SOD, etc.)
  • protein oxidation products (AOPP Dityrosin, ROH, etc.)

These evaluations help support your claims about the efficacy of anti-pollution products, protective products , anti-aging products, etc.

Screening des céramides

Screening des céramides – LC/MS

–

Cornéocytes endommagés et sains - SEMX500

Cornéocytes endommagés et sains – SEMX500

–

Analyse des PCA - LC/UV

Analyse des PCA – LC/UV

Quantification de la SOD

Quantification de la SOD

Data mapping and clinical imaging

Measurement of wrinkles, fine lines, and skin roughness, on whole face, in 2D imaging

On the high-resolution image of the whole face, image analysis makes it possible to monitor severity markers of visible wrinkles and fine lines.
Length, surface, depth, and projected volume are parameters that can be extracted to monitor the relief evolution induced by a treatment.
Image analysis algorithms are adapted to the required threshold of detection (first or marked wrinkles, fine lines or very small, oriented elements of the microrelief) and so can be used for any type of topic (wrinkles of a given area or of the whole face, different types of ethnicities with different types of wrinkles).
Newtone Technologies has developed specific algorithms for eye contour, lips, glabella, as well as for cheeks and nasolabial folds. These algorithms can be adapted to Caucasian, Asian, Hispanic, and African panels.
Roughness parameters can be extracted by image analysis and the evolution of skin smoothness can be monitored. 3D images can also be analyzed and can provide integrated parameters of roughness for the investigated surface.

Acquisition d’image du visage entier sans contrainte avec le ColorFace®

 ColorFace®

Process d'analyse des rides du contour de l'oeilProcess of analysis of eye contour wrinkles

Newtone SkinCam noire 010

Newtone SkinCam

Image acquisition of temple with SkinCam®

Measurement of pigment signs of sun ageing (lentigo) in 2 D

Skin ageing signs, such as solar lentigos, can be detected and analyzed by image analysis, on the whole face, on the back of the hand or by targeting a cutaneous lesion.
According to the area to be investigated, a choice will be made regarding the type of shot for the whole face, the hand, or a small sun-exposed area of the body (e.g., the upper chest).
The density of pigmentation spots, their surface, their color intensity, and the contrast measured with surrounding skin, as well as homogeneity of complexion are all parameters that can be extracted from this analysis.

Acquisition d’image du visage entier sans contrainte avec le ColorFace®

ColorFace®


Analysis of solar lentigos on the whole face, with images acquired with ColorFace®

DigiCam

DigiCam

Acquisition d’image du dos de la main avec le DigiCam ® et analyse des taches de pigmentation

Image acquisition of back of hand with DigiCam® and analysis of pigmentation spots

Newtone SkinCam noire 010

SkinCam

Image acquisition of temple with SkinCam®

Measurement of non-visible pigmentation in UV imaging

Investigation of sun-induced pigmentation, which is non-invisible but will appear with age, can be performed by using UV polarized monochrome imaging. Parameters such as lesion surface and density can be extracted and monitored over time.

Measurement of melanin in hyperspectral imaging

Newtone’s hyperspectral imaging is a unique technology developed to calculate the skin chromophore absorption mappings, and consequently to measure evolution over time, while providing a perfectly representative image of the measured evolution.
Acquisition systems allow image acquisition of the whole face (SpectraFace) or of a defined area of the body and face (SpectraCam).
On these images, pigment lesions can be monitored and analyzed as by color imaging, while discriminating melanin and hemoglobin.

Hyperspectral imaging

A project, an idea or a question? Contact us and let’s talk about it!
Find out about all our standard assays - Direct access to catalog

Skin ageing: posts and publications

skin photoaging irradiations

in vitro modeling of skin photoaging: development of evaluation tools for cosmetics

Cosmetics, Skin ageing

Development of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.

Read more
https://qima-lifesciences.com/wp-content/uploads/2017/03/Silab-Fig-2-2017-03-21.jpg 242 635 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-03-21 18:10:582019-09-13 21:45:10in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
ageing reconstructed epidermis

Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds

Cell and tissue engineering, Skin ageing

The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/12/Epiderme-reconstruit-passage-2-figure-1A-1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-12-21 16:21:562019-09-13 21:40:06Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds

Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study

Cosmetics, Cosmétique, Skin ageing

These data suggest that topical C-xyloside application in vivo may be efficient in inducing a better dermal-epidermal cohesion when such a junction is deficient, as is the case in photo-aged or chronologically aged skin. Moreover, a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Effect-of-C-xyloside.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2011-03-24 10:58:512019-11-13 11:34:13Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
tensin1

Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction

Cosmetics, Cosmétique, Skin ageing

tensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing

Read more
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Tensin1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-06-04 16:13:102019-11-13 11:34:03Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction

 

 

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  • La base légale du traitement est l’intérêt légitime du QIMA Life Sciences. Les données collectées seront communiquées aux seuls destinataires suivants : Les services concernés et habilités par QIMA Life Sciences. Les données sont conservées pendant une durée de 3 ans à compter de la collecte ou de votre dernier contact entrant.

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    N.B : Les catégories de données suivantes ; NOM / SOCIETE / EMAIL et PAR QUEL TYPE DE SERVICE ÊTES VOUS INTERESSE sont obligatoires. La non-fourniture de ces informations entrainera l’impossibilité pour QIMA Life Sciences de vous répondre.

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Address

QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
France - Labège, Lyon
Germany - Münster
USA - Buffalo, NY
Brazil - Botucatu, SP

Latest posts

  • Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts
  • Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers
  • Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
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Ressources documentaires


  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

  • La base légale du traitement est l’intérêt légitime du QIMA Life Sciences. Les données collectées seront communiquées aux seuls destinataires suivants : Les services concernés et habilités par QIMA Life Sciences. Les données sont conservées pendant une durée de 3 ans à compter de la collecte ou de votre dernier contact entrant.

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  • Les informations recueillies sur ce formulaire sont enregistrées dans un fichier informatisé par QIMA LIFE SCIENCES pour vous contacter afin de répondre à votre demande et vous aider à sélectionner le ou les tests les mieux adaptés à votre projet.

  • La base légale du traitement est l’intérêt légitime du QIMA Life Sciences. Les données collectées seront communiquées aux seuls destinataires suivants : Les services concernés et habilités par QIMA Life Sciences. Les données sont conservées pendant une durée de 3 ans à compter de la collecte ou de votre dernier contact entrant.

    Vous pouvez accéder aux données vous concernant, les rectifier, demander leur effacement ou exercer votre droit à la limitation du traitement de vos données, retirer votre consentement au traitement de vos données à tout moment, vous opposer au traitement de vos données et vous disposez d’un droit à la portabilité de vos données.

    Consultez le site cnil.fr pour plus d’informations sur vos droits.

    Pour exercer ces droits vous pouvez nous contacter à l’aide du lien suivant Gestion des droits ou en écrivant à dpo-qima@agencergpd.eu.

    Si vous estimez, après nous avoir contactés, que vos droits « Informatique et Libertés » ne sont pas respectés, vous pouvez adresser une réclamation à la CNIL.

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