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DHT testosterone ratio
5-alpha reductase activity

Sebocytes, testosterone metabolism & 5- alpha reductase activity (basal)

SEBO-0003


  • Context
  • Descriptions
  • Requirement
  • Study and reporting
  • See also
Biological Model

SEBO662 (Human sebocyte cell line)

Species

Human

EndPoint

5- alpha reductase activity

Method

[14C]-testosterone incorporation

Stimulation Factor

Basal

Compound Reference

Finasteride

Physiopathology

Skin and cutaneous appendices > Skin inflammation and disorders > Acne > Androgen metabolism
Skin and cutaneous appendices > Sebaceous glands > Androgens (response and metabolism)
Skin and cutaneous appendices > Skin inflammation and disorders > Oily skin

Feasibility, study proposal:

Our sales team is here to help you find solutions:
  • Technical feasibility study of your project
  • Development of an assay selection strategy
  • Definition of an experimental scheme
  • Financial assessment and contractual agreements (costs, turnaround time, non-disclosure agreements, etc.)
Please do not hesitate to get in touch with us.

Price: our pricing system consists of a fixed price per study + pricing per unit (price per replicate or experimental condition)

Start of assays and turnaround time: the start of an assay is subject to the receipt of your agreement and of the compounds to be tested. The sending date of the study report is communicated by email when the study starts. Although of an average of 5 to 10 weeks, our turnaround time may be subject to some fluctuation (due to availability of biological samples, to workload, etc.).

Required quantity of compounds: the required quantity is generally of a few mg or ml but may vary according to the form and solubility of compounds and to the concentrations to be tested. Please contact us for an estimation.

Customized protocols: for this assay, as for all of our assays, we can develop a protocol adapted to your needs. Should you have any question, please contact us.
Study management: each project requires advice and expertise so each study is managed and monitored by a dedicated study director who will be attentive to all your needs and questions.

Validation: the assays listed in the catalogue have undergone a preliminary validation and are subject to Standard Operating Procedures (SOPs) and to validation criteria. However, the robustness of each assay may be different according to the models and to the analytical methods. Please do not hesitate to contact us for more information.

Report and experimental data: our services include the writing of a study report in English or in French. This scientific report is provided in a PDF or Microsoft® Office format.

Laboratory / Location: this assay (as all of our assays) will be carried out in our Gençay laboratory in France.
Reference Title EndPoint Method
Reference Title EndPoint Method
NHEK-0184NHEK, PGE2 release (basal)*** (must be login)*** (must be login)
SEBOAR-0051SEBO662AR, viperin expression (Poly(I:C) stimulation)*** (must be login)*** (must be login)
SEBOAR-0023SEBO662AR, lipogenesis (testosterone + cadmium stimulation)*** (must be login)*** (must be login)
SEBOAR-0017SEBO662AR, RASD1 expression (Testosterone stimulation)*** (must be login)*** (must be login)
SEBO3D-00103D sebocytes, lipid accumulation (lipogenic stimulation)*** (must be login)*** (must be login)
NHEK-0301NHEK, gene expression, detoxification profile (basal)*** (must be login)*** (must be login)
RHEBACT_Lb-0001RHE, PGE2 release (Bacterial secretum stimulation)*** (must be login)*** (must be login)
SPL_Lb-0017Biological sample analysis - Analysis of sebum composition (neutral lipids)*** (must be login)*** (must be login)
SEBOAR-0001SEBO662AR, lipogenesis (basal)*** (must be login)*** (must be login)
SEBOAR-0012SEBO662AR, RASD1 expression (basal)*** (must be login)*** (must be login)

Address

QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com

International offices
France - Labège
USA - Buffalo, NY
Brazil - Botucatu, SP

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  • Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
  • Bioanalysis of non-invasive samples

Cosmetic

  • Hydration and skin barrier
  • Epidermal regeneration
  • Skin firmness & cohesion
  • Skin ageing
  • Skin protection & defense
  • Skin pigmentation
  • Oily skin and hyperseborrhea
  • Skin microcirculation and vascularization
  • Slimming and adipocyte metabolism
  • Hair growth and alopecia

Pharmacology

  • Immuno-Inflammation
  • Neurobiology
  • Veterinary medicine

Dermatology

  • Acne
  • Hair growth and alopecia
  • Atopic dermatitis
  • Psoriasis
  • Wound healing and skin regeneration
  • Melanoma
  • Vitiligo (coming soon)
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Sebocytes, proliferation (basal)SEBO-0001_Proliferation#RefRadiodetection3D sebocytes, testosterone metabolism & 5- alpha reductase activity (b... Scroll to top

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