Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants

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Atopic dermatitis (AD) is one of the most common, as yet incurable chronic inflammatory skin diseases, which occurs in distinct endotypes and shows increasing prevalence.

Atopic dermatitis

AD is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to 25% of the population.

Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis

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Specific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.
cytokine

Atopic dermatitis – initiation and chemokines activation step

The skin lesions facilitate the passage of an antigen that the subject has previously been sensitized to.
atopic dermatitis

Atopic dermatitis – immune response and skin lesions

TH2/TH22 immune response and other agents of atopic dermatitis After polarization, the Th2 and Th22 TL migrate to the lesion area, where they release type Th2 (IL-4, IL-5, IL-13, IL-31, TNF-α) and Th22 (IL-22) cytokines respectively. These Th2/Th22 cytokines have different functions in the immunity response.