QIMA Life Sciences has many in vitro or ex vivo models at your disposal:
- melanocyte cell lines (B16, etc.)
- normal human epidermal melanocytes (NHEM)
- co-culture of normal human epidermal keratinocytes and melanocytes (NHEK/NHEM)
- melanocyte-containing reconstructed epidermis (RHEm)
- skin explants (ex vivo)
- hair follicle (ex vivo)
on which we can evaluate the whitening or pro-pigmenting effect of active cosmetic compounds or formulations by measuring:
- the expression of specific markers of melanogenesis: TYR, TRP-1, Pmel17, MITF, etc.
- tyrosinase activity and expression
- melanin synthesis
- melanocyte dendricity
- melanosome transfer
Here are a few examples among all assays proposed by QIMA Life Sciences in the field of skin pigmentation:
