moclobemide

Moclobemide attenuates anoxia and glutamate induced neuronal damage in vitro independently of interaction with glutamate receptors subtypes

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The present study examined the in vitro effects of the antidepressant and type-A monoamine oxidase inhibitor, moclobemide, in neuronal-astroglial cultures from rat cerebral cortex exposed to anoxia (for 5 and 7 h) or to glutamate (2 mM for 6 h), two in vitro models of brain ischemia.