Ensemble des articles de QIMA Life Sciences traitant du développement de nouveaux modeles
https://qima-lifesciences.com/wp-content/uploads/2017/08/Mouse-epidermis.png 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-06-26 09:52:152019-11-13 11:16:35Development of a new model of reconstituted mouse epidermis and characterization of its response to proinflammatory cytokines
The development of three-dimensional models of reconstituted mouse epidermis (RME) has been hampered by the difficulty to maintain murine primary keratinocyte cultures and to achieve a complete epidermal stratification. In this study, a new protocol is proposed for the rapid and convenient generation of RME,
https://qima-lifesciences.com/wp-content/uploads/2016/12/Epiderme-reconstruit-passage-2-figure-1A-1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2016-12-21 16:21:562019-09-13 21:40:06Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
The development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
https://qima-lifesciences.com/wp-content/uploads/2016/03/mw_androgens-induce-sebaceous-differentiation-in-sebocyte.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2015-04-09 15:47:492019-11-13 11:16:58Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
In order to study the impact of active androgens in sebocytes, we constructed a stable human sebocyte cell line derived from SEBO662  constitutively expressing a fully functional AR. In these SEBO662 AR+ cells, dihydrotestosterone (DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Immortalized-sebocytes.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2012-01-24 10:17:152019-11-13 11:28:55Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
SEBO662 multilayers spontaneously differentiate into a sebaceous-like structure as shown by the strong polarized expression of the late sebaceous marker EMA, the overexpression of some lipogenic markers and lipid production on the upper side of the epithelium.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Human-embryonic-stem-cell-derivatives.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2009-11-21 15:43:332019-11-13 11:29:58Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.