QIMA Life Sciences 有许多与痤疮相关的体外或离体模型供您使用：
- 人皮脂腺细胞：SEBO662和SEBO662AR细胞系
- 正常人表皮角质形成细胞 (NHEK)
- 正常人真皮成纤维细胞 (NHDF)
- 人类卵泡真皮乳头细胞（HFDPC）
- 重建人表皮 (RHE)
QIMA Life Sciences 为您提供了一系列创新的体外药理学模型和分析，更专门致力于评估您产品（API，生物仿制药，制剂，医疗器械）的药理功效（筛选，分析，概念验证）：
- 皮脂腺调节和皮脂分泌过多
- 雄激素代谢
- 异常表皮分化
- 脂质过氧化
- 炎症、消炎或微生物反应
- 感染、免疫系统和皮肤防御
以下是 QIMA Life Sciences 在痤疮领域中提出所有检测方法中的一些例子：
Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiomeAcne is a skin pathology targeting the pilosebaceous unit…sebum hypersecretion and bacterial infection. We studied the effects of living bacteria on the induction of an innate immune response in a sebocyte cell line.
Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulationWe analysed the activity of reference anti-androgens (Finasteride, Dutasteride, Cyproterone acetate), at the level of their potential targets (5-alpha-reductase, AR translocation, induced transcripts) and in a functional lipid accumulation assay. We also evaluated this androgen-induced lipid accumulation assay as a potential pharmacological tool to detect potential inhibitors from both androgenic and non-androgenic origins.
Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulationAndrogens are key regulators of sebaceous function… A link between mTOR and androgen signaling has previously been reported…as well as a link between these processes and lipid synthesis…Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.