特应性皮炎，又称异位性湿疹，是一种尤其影响儿童的复发性炎症性皮肤病。这是由于表皮屏障功能障碍和对环境因素的过敏。自2000年以来，对这种严重皮肤病的预防性治疗的发现一直是制药和皮肤化妆品行业的一项特殊研究。
特应性皮炎：体外模型和检测
利用其在皮肤炎症和体外模型方面的长期专业知识，QIMA Life Sciences 在几年前启动了一项关于特应性皮炎的研究项目。
该项目使我们有可能开发和验证预测性体外药理学试验，以限制临床试验中的自然损耗。
下列体外药理学试验可用于筛选或评估特应性皮炎的潜在调节剂（原料药、生物仿制药、配方、医疗器械）：
- 免疫反应（Th2/Th22细胞因子释放，lg产生等）
- 皮肤敏化（嗜碱性细胞活化、组胺释放、神经肽生成等）
- 激活角质形成细胞或重建表皮的炎症反应
- 表皮分化、皮肤完整性与损伤、屏障功能及抗菌防护
- 特异性标记物的免疫检测或RT-qPCR-qPCR分析
以下是 QIMA Life Sciences 在特应性皮炎领域提出的所有标准测定中的几个例子：
Atopic dermatitis
Atopic dermatitisAD is the most common dermatosis affecting children: 65% of the patients are less than a year old and 85% are below 5 years. The prevalence of this pathology is constantly on the rise and currently affects 10 to
25% of the population.
Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis
Atopic dermatitis, Dermatite atopique, PsoriasisSpecific cytokine environment deregulation plays a central role on skin morphology and innate immunity, moving towards specific pathologies and opening the way to new therapeutic strategies.
Atopic dermatitis – initiation and chemokines activation step
Atopic dermatitisThe skin lesions facilitate the passage of an antigen that the subject has previously been sensitized to.
Atopic dermatitis – immune response and skin lesions
Atopic dermatitisTH2/TH22 immune response and other agents of atopic dermatitis
After polarization, the Th2 and Th22 TL migrate to the lesion area, where they release type Th2 (IL-4, IL-5, IL-13, IL-31, TNF-α) and Th22 (IL-22) cytokines respectively. These Th2/Th22 cytokines have different functions in the immunity response.
Keratinocytes as targets for cytokines in skin inflammation
Acne, Atopic dermatitis, Dermatology, PsoriasisCurrent knowledge about the effects of different cytokine families on keratinocytes, and more particularly theirinvolvement in skin inflammation and in the development of inflammatory skin diseases such as psoriasis