QIMA Life Sciences 提供许多可任由您自由支配的体外模型：
- 内在老化模型：
- “老年”人真皮成纤维细胞（Hayflick模型）
- “老年”人皮肤等效物（Hayflick模型）
- 加速老化模型：
- 氧化应激老化的人类真皮成纤维细胞（H2O2）
- 缺乏培养基中的人体重建皮肤
- 光老化模型：
- 人皮肤成纤维细胞经受UVA，红外或UV辐射
- 光老化人全厚度重建皮肤
在这些模型上，我们可通过衡量以下项来评估活性化妆品化合物的抗衰老效果：
- 细胞更新（细胞增殖，迁移和分化）
- 细胞外基质的合成和降解（胶原蛋白，弹性蛋白，透明质酸，MMPs等）
- 衰老标记表达
- 自由基产生
以下是 QIMA Life Sciences 在皮肤老化领域提出的所有标准测定中的几个例子：
in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
Cosmetics, Skin ageingDevelopment of in vitro models skin for better understand the modifications during photo-aging induced by repetitive UV exposure.
Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
Cell and tissue engineering, Skin ageingThe development of new anti-ageing products needs performant in vitro models mimicking morphological changes and physiological modifications appearing during skin ageing. In order to have access to a simple model mimicking the epidermis ageing but in relation with a normal dermis, we have developed a new in vitro model of reconstructed skin comprising an aged epidermis covering a reconstructed dermis built with collagen and normal (young) fibroblasts.
Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
Cosmetics, Cosmétique, Skin ageingThese data suggest that topical C-xyloside application in vivo may be efficient in inducing a better dermal-epidermal cohesion when such a junction is deficient, as is the case in photo-aged or chronologically aged skin. Moreover, a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.
Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
Cosmetics, Cosmétique, Skin ageingtensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing