QIMA Life Sciences 有许多体外或离体模型可供您使用:
- 正常人表皮角质形成细胞（NHEK）
- 重建人表皮（RHE）
- 皮脂腺细胞（SEBO662AR）
- 全厚皮（FTSK）
- 皮肤外植体（离体）
在这些模型上，我们可通过衡量以下项来逐项评估活性化合物或制剂的保湿效果：
- 屏障功能的增强
- 表皮分化的刺激（例如聚丝蛋白，外皮蛋白，转谷氨酰胺酶，细胞角蛋白）
- 脂质合成（酸性地幔）：
- 皮脂
- 表皮脂质（例如神经酰胺，脑苷脂和磷脂）
- 表皮细胞外基质成分的表达或合成：
- 糖胺聚糖和透明质酸
- 蛋白多糖和ECM受体
- 蛋白酶（例如 MMPs）
- 表皮粘附和细胞间细胞连接的标志物的表达：
- 闭塞连接蛋白和附着蛋白（封闭蛋白，蛋白，桥粒核心糖蛋白等）
- 皮肤表皮结（例如整合素V，胶原蛋白IV，胶原蛋白VII等）
- 间隙连接（例如连接蛋白）和分子通道（例如水通道蛋白）
以下是 QIMA Life Sciences 在保湿和增强屏障功能领域提出的所有标准测定中的几个例子：
Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Barrière cutanée et hydratation, Cosmetics, Cosmetics, Cosmétique, Expression de gènes, Skin barrier and hydrationHelichrysum italicum (Roth) G. Don subsp. italicum (H. italicum italicum) from the Asteraceae family grows on dry, rocky or sandy ground around the Mediterranean Basin and is commonly known as the everlasting plant.
Facial skin mapping: from single point bio‐instrumental evaluation to continuous visualization of skin hydration, barrier function, skin surface pH, and sebum in different ethnic skin types
Barrière cutanée et hydratation, Cosmetics, CosmétiqueDry skin is one of the most important concerns of consumers worldwide. Despite huge efforts over several decades, the personal care industry still does not offer a perfect solution to satisfy the unmet needs of consumers for moisturising treatments in different ethnic groups.
Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Barrière cutanée et hydratation, Médecine vétérinaire, Skin barrier and hydration, Veterinary medicineFilaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis.
New Biological Activities of Lythrum salicaria L.
Barrière cutanée et hydratation, Cosmetics, Cosmétique, Skin barrier and hydrationThe perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine.
La glande sébacée : Physiologie et fonctions
Acné, Barrière cutanée et hydratation, Peau grasse, hyperséborrhée et séborégulationLa glande sébacée est un organe localisé au niveau du derme. Elle est responsable de la synthèse et de la sécrétion du sébum qui entre dans la composition du film hydrolipidique. Le rôle du sébum est de protéger la peau des agressions extérieures et de la déshydratation. Le sébum permet également d’entretenir la souplesse de la peau et des cheveux.
New biological effects of Aphloïol
Barrière cutanée et hydratation, Cosmetics, Cosmétique, Skin barrier and hydrationIn the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
Rab11a Is Essential for Lamellar Body Biogenesis in the Human
Barrière cutanée et hydratation, Skin barrier and hydrationMost of the skin barrier function is attributable to the outermost layer of the epidermis, the stratum corneum, which is composed of flattened, anucleated cells called corneocytes surrounded by a lipid-enriched lamellar matrix.