Keratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis

European Cytokine Network, 16(4):309-19


Laboratoire Cytokines et Inflammation, UPRES-EA 3806, CHU de Poitiers, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.
Bioalternatives, 1 bis rue des plantes 86160 Gençay, France.
Service de Chirurgie Plastique, CHU La Milétrie, 86022 Poitiers, France.
Service de Dermatologie, CHU La Milétrie, 86022 Poitiers, France.


Cytokines are key factors in the cross talk between the immune system and other systems including hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune response and inflammation. IL10 is one of the most important anti-inflammatory cytokines. Five cytokines structurally related to IL10 have been described and presently form this family of cytokines: IL19, IL20, IL22, IL24 and IL26. In contrast to IL10, these cytokines display pro-inflammatory activities in different tissues, including skin. Indeed, some of them induce an inflammatory keratinocyte gene expression profile and an epidermis histology resembling psoriatic lesions.
In this review, we discuss recent knowledge about the effects of cytokines of the IL10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory disease.

© 2005 K. Boniface, et al.

KEYWORDS: Cytokines; Skin; Keratinocyte; Inflammation; Psoriasis; IL10

Check out Bioalternatives’ updates and experience new testing ideas

  • Bioassays, models and services
  • Posts and publications
  • Events
  • The legal basis for the processing is consent. Your e-mail address will only be communicated to the following recipients: the departments concerned and authorised by QIMA LIFE SCIENCE. This data is kept for as long as you are registered to the newsletter.

    You can access your data, rectify it, request its deletion or exercise your right to limit the processing of your data, withdraw your consent to the processing of your data at any time, oppose the processing of your data and you have a right to the portability of your data.

    Visit for more information on your rights.
    You can exercise all your rights using the following linkGestion des droits or by writing to If you feel, after contacting us, that your "Informatique et Libertés" rights are not being respected, you can submit a complaint to the CNIL.

  • The information collected on this form is recorded in a file used by QIMA Life Sciences to send you its newsletter.