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Skin tissue engineering
and dermocosmetic applications
Customized 3D reconstructed models for cosmetic

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Skin barrier & Hydration
Examples of results from in vitro testing to clinical imaging

CONTRACT RESEARCH LABORATORY
in vitro pharmacology, cell and tissue engineering, bioanalysis, assay development

COSMETICS
in vitro and ex vivo efficacy studies of cosmetic products: oily skin, dry skin, hydration, skin ageing, pigmentation, hair growth, etc.
+ 300 COSMETIC EFFICACY ASSAYS

DERMATOLOGY
Bioassays and in vitro models for preclinical research: psoriasis, atopic dermatitis, wound healing, acne, alopecia, pigmentation, etc.
+ 300 BIOASSAYS

PHARMACOLOGY
Bioassays for pharmaceutical preclinical research: neurobiology, immuno-inflammation, veterinary medicine.
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POSTS AND PUBLICATIONS


A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke
Cosmetics, Cosmetics, Cosmétique
Anti-pollution effects of two antioxidants and a chelator-Ex vivo electron spin resonance and in vivo cigarette smoke model assessments in human skin
Cosmetics
Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
Cosmetics, Dermatology

Type-1 cytokines regulate MMP-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo
Pigmentation


Using Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome, Skin microbiome



Profiling TLR agonist activity in keratinocytes and link to bacteria-induced innate immunity activation
Cosmetics, Microbiome cutané, Skin microbiome





Behavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line.
Cosmetics
Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome
Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulation
Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation
Pollution and epigenetics: Histone H3 modifications in keratinocytes after exposure to urban dust and Benzo(a)pyrene
Cosmetics, Cosmetics, Cosmétique, Skin protection and immune defense system
Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Barrière cutanée et hydratation, Médecine vétérinaire, Skin barrier and hydration, Veterinary medicine
Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis
Cosmétique, Microbiome cutané, Skin microbiome
Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles
Cosmetics, Inflammation, Pharmacology

Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
Cosmetics, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation, Skin protection and immune defense system

Physiology and functions of the sebaceous gland
Acne, Sebaceous gland regulation, Skin barrier and hydration

A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study
Cosmetics, Cosmetics, Cosmétique

in vitro modeling of skin photoaging: development of evaluation tools for cosmetics
Cosmetics, Skin ageing
Development of a new model of reconstructed aged skin useful to study antiageing effects of cosmetic compounds
Cell and tissue engineering, Skin ageing
Rab11a Is Essential for Lamellar Body Biogenesis in the Human
Barrière cutanée et hydratation, Skin barrier and hydration
Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
Acne, Cell and tissue engineering, Sebaceous gland regulation

Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
Acne, Cell and tissue engineering, Sebaceous gland regulation
Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
Cosmetics, Cosmétique, Skin ageing
Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE)
Adipocyte metabolism, Cosmetics, Cosmétique
Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
Cosmetics, Cosmétique, Skin ageing
Alternative (non-animal) methods for cosmetic testing: current status and future prospects – UV-induced effects
Cosmetics, Cosmétique, Safety and tolerance
Alternative (non-animal) methods for cosmetic testing: current status and future prospects – Acute toxicity
Cosmetics, Cosmétique, Safety and tolerance
Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis
Cosmetics, Cosmétique, Epidermal regeneration
Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis
Safety and tolerance
Metrology and sensors as dermo-cosmetic technology opportunities for a change of paradigm
Cosmetics, Dermatology

Using Reconstructed Human Epidermis model in Skin Microbiome Research
Skin microbiome, Skin microbiome


Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT.
Acne, Microbiome cutané, Sebaceous gland regulation, Skin microbiome, Skin microbiome
Pharmacological effects of anti-androgens and other compounds in an androgen-sensitive sebocyte cell line.
Acne, Sebaceous gland regulation
Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Acne, Peau grasse, hyperséborrhée et séborégulation, Sebaceous gland regulation


Physiology and functions of the sebaceous gland
Acne, Sebaceous gland regulation, Skin barrier and hydration
Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
Psoriasis
A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
Acne, Acné



Imiquimod-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome
Psoriasis
Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor
Acne, Cell and tissue engineering, Sebaceous gland regulation
Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children
Wound healing
Epidermal healing in burns: autologous keratinocyte transplantation as a standard procedure: update and perspective
Wound healing
Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M
Inflammation, Psoriasis

Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts
Wound healing
Keratinocytes under fire of proinflammatory cytokines: Bonafide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis
Atopic dermatitis, Dermatite atopique, Psoriasis


Immortalized sebocytes SEBO662 can spontaneously differentiate into a sebaceous-like phenotype when cultured as a 3D epithelium
Acne, Cell and tissue engineering, Sebaceous gland regulation
Quantitative and qualitative study in keratinocytes from foreskin in children: Perspective application in paediatric burns
Wound healing
Skin inflammation induced by the synergistic action of IL17A, IL22, OSM, IL1α and TNFα recapitulates some features of psoriasis
Psoriasis
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
Cell and tissue engineering, Dermatology, Pharmacology, Wound healing

Keratinocytes as targets for cytokines in skin inflammation
Acne, Atopic dermatitis, Dermatology, Psoriasis
Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils
Psoriasis

OSM (Oncostatin M) secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation
Psoriasis
Keratinocytes as targets for IL10-related cytokines : a putative role in psoriasis pathogenesis
Psoriasis
Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing
Wound healing
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
Inflammation, Psoriasis
Expression of type 1 5-alpha-reductase and metabolism of testosterone in reconstructed human epidermis
Acne, Dermatology
Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results
Médecine vétérinaire, Veterinary medicine
Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
Pharmacologie, Pharmacology
Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study
Médecine vétérinaire, Veterinary medicine
Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs
Veterinary medicine
Evaluation of the anti-inflammatory and immunomodulatory effects of a product using in vitro canine whole blood models
Veterinary medicine

Evaluation of the effect of a reference molecule on an Atopic Reconstructed Canine Epidermis model (RCE-AD)
Veterinary medicine
A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coats
Veterinary medicineAddress
QIMA Life Sciences
Headquarters
1bis rue des plantes - CS 50011
86160 Gençay - France
Tel. +33 (0) 5 49 36 11 37
Mail: ls@qima.com
International offices
France - Labège
USA - Buffalo, NY
Brazil - Botucatu, SP
Latest posts
- Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results
- Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells
- Bioanalysis of non-invasive samples