New Biological Activities of Lythrum salicaria L.: Effects on Keratinocytes, Reconstructed Epidermis and Reconstructed Skins, Applications in Dermo-Cosmetic Sciences

Cosmetics 2017, 4(52)


Greenpharma,  SAS, 3 allée du Titane, 45100 Orléans, France.
ICOA (Institut de Chimie Organique et Analytique), Université d’Orléans, CNRS, UMR 7311, rue de Chartres, 45100 Orléans, France.
Bioalternatives, Gençay, France.


The perennial and widespread herb Lythrum salicaria L., also called purple loosestrife, is a plant that is traditionally used in European medicine. Purple loosestrife is known for its ability to treat internal disorders, such as gastrointestinal issues or hemorrhages. Our objective was to take another look on this natural source of ellagitannins in terms of biological activities. Exploration of the phytochemical content of an extract of aerial parts of Lythrum salicaria L. was completed before initiating research on its biological effects towards keratinocytes, reconstructed epidermis, and skins. The potential of the natural compounds were evaluated by topical treatment of reconstructed tissues. The extract and one of its major compounds were able to act as pro-differentiating and protecting agents towards skin cells by stimulating the expressions of markers taking part in the structure of epidermis and dermis. Also, the extract showed beneficial effects on the global morphology of the skin. Thus, Lythrum salicaria L. constitutes a new natural source for the development of active
ingredients for the dermo-cosmetic field.

© 2017 Published by MDPI AG, Basel, Switzerland

KEYWORDS: Lythrum salicaria L.; purple loosestrife ; natural extract ; vescalagin ; skin barrier function ; epidermis ; differentiation ; TGK ; 3D model

Related posts

Check out Bioalternatives’ updates and experience new testing ideas

  • Bioassays, models and services
  • Posts and publications
  • Events
  • The legal basis for the processing is consent. Your e-mail address will only be communicated to the following recipients: the departments concerned and authorised by QIMA LIFE SCIENCE. This data is kept for as long as you are registered to the newsletter.

    You can access your data, rectify it, request its deletion or exercise your right to limit the processing of your data, withdraw your consent to the processing of your data at any time, oppose the processing of your data and you have a right to the portability of your data.

    Visit for more information on your rights.
    You can exercise all your rights using the following linkGestion des droits or by writing to If you feel, after contacting us, that your "Informatique et Libertés" rights are not being respected, you can submit a complaint to the CNIL.

  • The information collected on this form is recorded in a file used by QIMA Life Sciences to send you its newsletter.