Performance and Tolerance of a Protocol for Idiopathic Chronic Greasy Seborrhea in 18 Dogs Using a Shampoo and Mousse Containing Plant Extracts

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The study aimed to evaluate the tolerance, performance and effect on hair lipids and skin hydration of a protocol combining applications of one shampoo and subsequent mousses containing plant extracts (Ophytrium and Seboliance) in dogs with an undiagnosed chronic greasy keratinisation disorder.

Clinical and Microbiological Performances and Effects on Lipid and Cytokine Production of a Ceruminolytic Ear Cleaner in Canine Erythemato-Ceruminous Otitis Externa

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Erythemato-ceruminous otitis externa (ECOE) is the most common type of otitis in dogs and is generally associated with bacterial and/or yeast infections.

Multiplex Cytokine Analyses in Ear Canals of Dogs Suggest Involvement of IL-8 Chemokine in Atopic Otitis and Otodectic Mange—Preliminary Results

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Atopic dermatitis is a form of allergy of genetic origin accompanied by itching, during which the animal more easily develops allergies to environmental factors, usually pollen and dust mites.

Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells

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Besides actions including their venotonic, anti-inflammatory, and anti-oxidant effects, venoactive drugs are expected to act on edema via their action on lymphatics.

Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study

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Conjunctivitis in atopic dogs has already been described yet is rarely observed, and likely underdiagnosed in practice.

Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs

Performance of shampoo and subsequent mousse applications was assessed in seborrheic dogs. Shampoo and leave-on mousse applications resulted in a significant improvement...
Evaluation of mean inhibition - canine whole bool model
in vitro canine models
Photometry
Dog Skin - Epidermal Cornification Proteins

Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles

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Preservative-free cationic emulsion-based artificial tears (ATs) or drug vehicles are innovative eye drop formulations with tear film stabilization and drug delivery properties, and valuable in vivo anti-inflammatory and wound healing properties.
Tg2576 Alzheimer

Biosimilars

The term “biosimilar” emerged in the 1980s and describes a biological product identical in all respects (dosage form, active ingredient, chemical and biological characteristics) to an original, already marketed, biological drug (vaccine, antibody, growth factor, etc.) that is no longer under patent protection. La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques
autophagy

Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast

Cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.

IL22/IL-22R pathway induces cell survival in human glioblastoma cells

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Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases.

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

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This study highlights the precise role of cytokines in the skin inflammatory response (psoriasis). IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
HNF1β prostate cancer

Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression

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Genome-wide association studies have identified variants at multiple loci associated with prostate cancer (PCa) risk. Some of these loci include candidate susceptibility genes, such as MSMB, HNF1β, and C-terminal-binding protein (CtBP2). Except for MSMB, the clinicopathological significance of these genes has not been investigated. We therefore aimed to analyze their expression in PCa tissues, in relation with tumor progression and aggressiveness.

Contribution of IL22 to experimental skin inflammation

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Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.