Survey of cytokines on ocular surfaces of atopic dogs by multiplex analysis using two sampling methods – a pilot Study

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Conjunctivitis in atopic dogs has already been described yet is rarely observed, and likely underdiagnosed in practice.

Effects on clinical signs, lipids and hydration factors of combined applications of shampoo and mousse containing Ophytrium and Seboliance in seborrheic dogs

Performance of shampoo and subsequent mousse applications was assessed in seborrheic dogs. Shampoo and leave-on mousse applications resulted in a significant improvement...
Evaluation of mean inhibition - canine whole bool model
in vitro canine models
Photometry
Dog Skin - Epidermal Cornification Proteins

Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles

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Preservative-free cationic emulsion-based artificial tears (ATs) or drug vehicles are innovative eye drop formulations with tear film stabilization and drug delivery properties, and valuable in vivo anti-inflammatory and wound healing properties.
Tg2576 Alzheimer

Biosimilars

The term “biosimilar” emerged in the 1980s and describes a biological product identical in all respects (dosage form, active ingredient, chemical and biological characteristics) to an original, already marketed, biological drug (vaccine, antibody, growth factor, etc.) that is no longer under patent protection. La démonstration de la similarité en termes de sécurité et d’efficacité entre les deux produits biologiques est un processus complexe qui requiert notamment de nouveaux essais précliniques
autophagy

Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast

Cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.

IL22/IL-22R pathway induces cell survival in human glioblastoma cells

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Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases.

Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M

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This study highlights the precise role of cytokines in the skin inflammatory response (psoriasis). IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
HNF1β prostate cancer

Expression patterns of candidate susceptibility genes HNF1β and CtBP2 in prostate cancer: Association with tumor progression

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Genome-wide association studies have identified variants at multiple loci associated with prostate cancer (PCa) risk. Some of these loci include candidate susceptibility genes, such as MSMB, HNF1β, and C-terminal-binding protein (CtBP2). Except for MSMB, the clinicopathological significance of these genes has not been investigated. We therefore aimed to analyze their expression in PCa tissues, in relation with tumor progression and aggressiveness.

Contribution of IL22 to experimental skin inflammation

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Focused on in vitro human models, we present the mechanisms of action of IL22 as well as its involvement in structure, metabolism, differentiation, chemotaxis, antibacterial activity, innate immunity, and tissue remodeling of epidermis.

Involvement of IL-1 and Oncostatin M in acanthosis associated with hypertensive leg ulcer

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Hypertensive leg ulcer (HLU) is an inflammatory disease characterized by intense pain, alteration of vascularization, and skin necrosis. The optimal treatment relies on surgical removal of necrotic tissues covered by a split-skin graft.

The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells

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We investigated the effect of the increased Cx43 expression, by retroviral infection, on the metastatic behaviour of two well-characterized cell lines (PC-3 and LNCaP) representing different stages of PCa progression. It appeared that Cx43 differently behaved in those cell lines and induced different phenotypes.

CCL20 and β-defensin-2 induce arrest of human Th17 cells on inflamed endothelium in vitro under flow conditions

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These results indicate that Ag-specific activation will initially contribute to CCR6-mediated Th17 cell trafficking toward and sequestration in inflamed tissue, but that it eventually results in a transitory state of nonresponsiveness to further stimulation of these cells with CCR6 ligands, thus permitting their subsequent migration out of the inflamed site.

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

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To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells' capability of constructing a pluristratified epidermis.