https://qima-lifesciences.com/wp-content/uploads/2022/01/mw_Skin-damage-pathways.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2021-08-25 10:44:592022-01-25 10:48:03A novel clinical method to measure skin staining reveals activation of skin damage pathways by cigarette smoke
https://qima-lifesciences.com/wp-content/uploads/2019/05/190527_Poster4_petit.png 368 655 Vanessa https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Vanessa2019-05-22 14:37:042019-11-12 17:39:16Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line.
Androgens are key regulators of sebaceous function... A link between mTOR and androgen signaling has previously been reported...as well as a link between these processes and lipid synthesis...Here we aimed at confirming that DHT-induced lipid synthesis/accumulation is at least in part dependent on mTOR activation in the SEBO662AR cell line and that the autophagic process is consequently modified by the androgenic treatment.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_AdobeStock_bannierePROTECTION-DEFENSE.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2019-03-17 11:20:102019-09-13 21:46:38Pollution and epigenetics: Histone H3 modifications in keratinocytes after exposure to urban dust and Benzo(a)pyrene
In this work, human epidermal keratinocytes were used to study the effects of urban dust and benzo(a)pyrene on the epigenetic pattern of the histone H3 protein. The assay was then used to screen a series of plant extracts in order to find cosmetic actives to protect the skin against air pollution.
https://qima-lifesciences.com/wp-content/uploads/2021/08/mw_Dog-Skin-Epidermal-Cornification-Proteins.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2019-02-01 13:14:402021-08-30 13:14:58Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin
Filaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis.
https://qima-lifesciences.com/wp-content/uploads/2019/01/mw_Pseudomonas.jpg 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2018-08-02 15:40:162019-11-13 11:39:19Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis
Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous infection.
https://qima-lifesciences.com/wp-content/uploads/2017/11/SEPPIC-Image-à-la-une.jpg 640 1140 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-11-29 10:57:192019-09-13 07:39:35Effects of different kinds of pollutants on the lipidic metabolism of human sebocytes and protective effects of a new macroalgae culture extract
Sebocytes lipid production are stimulated by pollutants. Ame acts by protecting epidermal cells, human sebocytes and skin from urban dust.
https://qima-lifesciences.com/wp-content/uploads/2021/08/mw_Skin-care-complex.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2017-04-01 13:51:362021-08-30 13:51:55A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study
In addition to the natural process of skin aging, the skin of women is significantly impacted during and after menopause.
https://qima-lifesciences.com/wp-content/uploads/2017/03/KRT10-Vit-C-_-2017-03-23.jpg 567 800 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2017-03-24 12:03:322019-09-13 21:35:41New biological effects of Aphloïol
In the present study, we identified new properties of Aphloïol (syn. mangiferin) in improving skin barrier function, especially by promoting keratinocyte differentiation, synthesis of transmembrane glycoprotein and lipid neosynthesis.
https://qima-lifesciences.com/wp-content/uploads/2021/08/mw_Rab11.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2016-06-01 14:32:342021-08-30 14:33:00Rab11a Is Essential for Lamellar Body Biogenesis in the Human
Most of the skin barrier function is attributable to the outermost layer of the epidermis, the stratum corneum, which is composed of flattened, anucleated cells called corneocytes surrounded by a lipid-enriched lamellar matrix.
https://qima-lifesciences.com/wp-content/uploads/2021/08/mw_Scalp-surface-lipids.png 368 655 Julie https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Julie2016-01-12 14:58:422021-08-30 14:59:01Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition
Dandruff is a common but complex disorder with three major contributing factors: (1) individual predisposition, (2) scalp sebum and (3) Malassezia yeast colonization.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Effect-of-C-xyloside.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2011-03-24 10:58:512019-11-13 11:34:13Effect of C-xyloside on morphogenesis of the dermal epidermal junction in aged female skin. An ultrastuctural pilot study
These data suggest that topical C-xyloside application in vivo may be efficient in inducing a better dermal-epidermal cohesion when such a junction is deficient, as is the case in photo-aged or chronologically aged skin. Moreover, a statistically significant increase in CD44 expression was noted in the epidermis of C-xyloside-treated compared to the placebo treated skin areas.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Lipolytic-effect-of-a-polyphenolic-citrus-dry-extract.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-07-09 14:18:052019-11-13 11:42:20Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (Sinetrol) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-Phosphodiesterase (PDE)
The present study investigated the lipolytic (break of fat stored) effect of a citrus-based polyphenolic dietary supplement (SINETROL) at human adipocytes (ex vivo), body fat (clinical) and biochemical levels (inhibition of phosphodiesterase).
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Tensin1.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2008-06-04 16:13:102019-11-13 11:34:03Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction
tensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_UV-induced-effects.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2005-05-30 10:47:442019-05-31 15:11:46Alternative (non-animal) methods for cosmetic testing: current status and future prospects – UV-induced effects
Cosmetic ingredients and mixtures of ingredients absorbing UV light (in particular UV filter chemicals used, for example, to ensure the light stability of cosmetics or used in sun protection products) should be tested for acute phototoxic and photogenotoxic potential.
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Acute-toxicity.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2005-05-30 10:22:572019-05-31 15:12:41Alternative (non-animal) methods for cosmetic testing: current status and future prospects – Acute toxicity
From the regulatory point of view, the main objective of acute toxicity testing is basically to classify chemicals according to their intrinsic toxicity
https://qima-lifesciences.com/wp-content/uploads/2016/05/mw_Comparison-of-gene-expression-profiles.jpg 368 655 Guillaume https://qima-lifesciences.com/wp-content/uploads/2021/10/QIMA_life_sciences@4x1.png Guillaume2002-02-10 11:25:232019-05-31 15:14:16Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis
In order to validate a model for predictive screening of dermatological drugs, we used a customized cDNA macro-array system containing 475 skin-related genes to analyze the gene expression patterns in human keratinocytes from different origins.